摘要:

Antiepileptic drugs, such as carbamazepine and sodium valproate, are integral to psychopharmacologic therapy over the last decades. Lamotrigine is a new antiepileptic drug that acts on amino acid neurotransmitters/neuromodulators, most prominently, glutamine, which has been reported to have potential mood-stabilizing effects. The reports on this effect are limited and sparse, and systematic investigations have not been published. Here we present two clinical cases representing atypical patient groups in which lamotrigine was successfully used as an add-on therapy for resistant bipolar depression.

ISSN:0362-5664    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

We report on a schizophrenic patient whose tardive dystonia, delusions, and auditory hallucinations showed remarkable concurrent improvement after replacing haloperidol with risperidone. The present finding suggests that the 5-hydroxytrypta-mine-2 (5-HT2) antagonistic action of risperidone has brought about the improvement in tardive dystonia. The 5-HT2antagonistic action of risperidone, in addition to its dopamine antagonistic action, may have also lessened psychotic symptoms in the current case.

ISSN:0362-5664    

出版商:OVID    

年代:1998

数据来源: OVID