摘要:

We have recently shown that compounds with high affinity for peripheral-type benzodiazepine receptors inhibited glucose-induced insulin secretion in vitro. We therefore performed an oral glucose tolerance test in anxious inpatints treated with the imidazopyridine derivative alpidem, which has been shown to display high affinity for these binding sites. The test was performed before and after 1 week of daily administration of the drug. As compared with pretreatment values, a significant alteration of the insulin response to glucose was observed. It is suggested that daily administration of alpidem, at therapeutically effective doses for the treatment of anxiety, may alter glucose tolerance.

ISSN:0362-5664    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

In nine patients with orthostatic hypotension due to multiple system atrophy, the effects of octreotide (100 μg s.c.), a somatostatin analogue, on blood pressure (BP), heart rate (HR), and norepinephrine (NE) plasma levels after 60° head up hit test were evaluated by a randomly controlled study. Octreotide increased sapine BP, tilt-test duration (+ 28%), and delay to obtain minimal BP during the 60° head up tilt (+ 50%). Octreotide changed neither HR nor NE plasma levels.

ISSN:0362-5664    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Sleep disturbances are found in most depressive patients. Serotonin reuptake inhibitors, such as fluoxetine hydrochloride, seem to improve sleep by changing the depressive affect and the underlying biological mechanisms. Insomnia is an occasional adverse effect of the medication, but it was shown that only 2–3% of the patients with fluoxetine-induced insomnia discontinued the drug for this reason. We could not find any report of nightmares or night terrors under fluoxetine treatment. We report on four patients who experienced nightmares on fluoxetine monotherapy.

ISSN:0362-5664    

出版商:OVID    

年代:1995

数据来源: OVID