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1. |
Introduction |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 1-2
Abraham Lieberman,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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2. |
Early Parkinsonism |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 3-8
D. Calne,
A. Stoessl,
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PDF (407KB)
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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3. |
Management of Levodopa FailuresThe Use of Dopamine Agonists |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 9-21
Abraham Lieberman,
Govindan Gopinathan,
Andreas Neophytides,
Menek Goldstein,
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摘要:
In the past decade, dopamine agonists have emerged as important treatment options for patients with Parkinson's disease. Originally, dopamine agonists were used only in patients with advanced disease in whom the response to levodopa had decreased (levodopa failures). The decreased response to levodopa, usually associated with diurnal oscillations in performance and the ‘wearing-off’ and ‘on-off phenomena, is secondary to disease progression with continued degeneration of the nigrostriatal neurons. In addition, chronic levodopa treatment itself may contribute to the decreased drug response and the diurnal oscillations in performance. Dopamine receptor agonists bypass the degenerating nigrostriatal neurons and directly stimulate the striatal dopamine receptors. Dopamine receptor agonists also permit a reduction in the dose of levodopa. Five ergoline dopamine agonists-bromocriptine, lergotrile, pergolide, lisuride, mesulergine, and the nonergoline agonist, ciladopa-have undergone clinical trials in Parkinson's disease. In 10 years, we treated a total of 278 patients with advanced Parkinson's disease, a declining response to levodopa, and diurnal oscillations in performance with five ergoline dopamine agonists (in addition to levodopa). The mean duration of treatment was one year (with a range of 1–60 months). Improvement was noted in 140 (50%) of our patients. Adverse effects necessitating discontinuation of the agonist occurred in 131 patients (46%). We compared our results with those of others who, unlike us, began treatment with a dopamine agonist earlier, using the agonist alone or adding it to levodopa before the response to levodopa had decreased. Many of the patients so treated had mild or moderate Parkinson's disease. A total of 1,599 patients were treated with ergoline dopamine agonists. Of these patients, 976 (61%) improved, while 407 (25%) experienced adverse effects. We believe that a greater number of these patients improved and fewer experienced adverse effects, in comparison to our patients, because the patients had less advanced disease.
ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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4. |
Parkinson's Disease and Dementia |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 22-36
Yves Agid,
Merle Ruberg,
Bruno Dubois,
Bernard Pillon,
Guliana Cusimano,
Rita Raisman,
Roland Cash,
François Lhermitte,
France Javoy-Agid,
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PDF (1067KB)
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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5. |
Generalized DystoniaConcept and Treatment |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 37-48
Stanley Fahn,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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6. |
The Focal Dystonias |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 49-60
C. Marsden,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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7. |
The Pharmacological Management of Essential Tremor |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 61-75
Leslie Findley,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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8. |
Tardive DyskinesiaPrevention and Treatment |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 76-84
Caroline Tanner,
Harold Klawans,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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9. |
On Chorea |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 85-99
Ira Shoulson,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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10. |
Recent Advances in the Management of Tics |
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Clinical Neuropharmacology,
Volume 9,
Issue 2,
1986,
Page 100-110
Joseph Jankovic,
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ISSN:0362-5664
出版商:OVID
年代:1986
数据来源: OVID
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