ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

Six patients with myoclonus were given 0.1–0.15 mg lisuride i.v. All patients had stimulus-sensitive myoclonus and an increased size of somatosensory evoked potentials, and in three there was electrophysiological evidence of a cortical event time-locked to the jerks. All subjects showed a considerable diminution of spontaneous, action-and stimulus-evoked jerking. Lisuride has potent central dopaminergic and serotonergic actions. Administration of the dopamine agonists levodopa or apomorphine had no effect on myoclonic jerking in any of the six patients. Detailed pharmacological analysis of the myoclonus in one patient showed that levodopa, apomorphine, and haloperidol had no effect, and that haloperidol did not prevent the therapeutic action of lisuride. 5-Hydroxytryptophan abolished the myoclonus, and methysergide prevented the beneficial effect of lisuride, although it did not alter spontaneous myoclonus. These observations suggest that lisuride improves some types of reflex, stimulus-sensitive cortical myoclonus by a serotonin agonist action.

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

Baclofen has been reported to be an analgesic in a wide variety of animal pain models. To study the analgesic potential of baclofen in humans, we used a postoperative dental pain model. Thirty-three patients were enrolled in a double-blind study using either baclofen, acetaminophen, or placebo. There was a statistically significant difference in pain reduction at 1 and 2 h after acetaminophen ingestion, compared to that of placebo. Baclofen was not statistically superior to placebo at any one of the four hourly measurements. In contrast to the promising animal work with baclofen as an analgesic, our study in humans does not support the notion that baclofen is an analgesic.

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

In rat striatum, frontal decortication did not affect the basal and the haloperidoi-induced increases in dopamine (DA) turnover and the elevation in DA and dihydroxyphenylacetic acid concentrations produced by systemic administration of L-Dopa, These findings fail to support a role for the corticostriatal afferents in modulation of dopamine synthesis and release by nigrostriatal neurons. They suggest that DA receptors presumably localized on presynaptic corticostriatal terminals do not mediate the acceleration of DA turnover induced by neuroleptics. Data also indicate that corticostriatal terminals do not represent a locus for decarboxylation of exogenous L-Dopa to DA in the striatum.

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1983

数据来源: OVID