摘要:

The condition of the corneal epithelium of 57 non-, 18 soft-, 29 gas-permeable-and 26 hard contact lens-wearing eyes was investigated by fluorophotometric determination of the corneal epithelial permeability.The mean permeability values for non-, soft-, gas-permeable-and hard contact lens-wearing eyes were 0.040 nm/s + 0.017 SD, 0.02U nm/s + 0.009 SD, 0.028 nm/s + 0.017 SD and 0.044 nm/s + 0.020 SD, respectively. The mean permeability values for soft and gas-permeable contact lens-wearing eyes were significantly lower than that for non contact lens-wearing eyes (-40%, p<0.0001 and-30%, p<0.005); no significant difference was found between the mean values for hard and non contact lens-wearing eyes (p=0.38).

ISSN:0271-3683    

DOI:10.3109/02713688809031805

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

Spontaneous rejection of syngeneic intraocular P91 mastocytoma occurred by a T cell-dependent immune process that produced extensive, irreparable damage to normal ocular tissues indicative of a delayed-type hypersensitivity (DTH) lesion. We investigated the contribution of other effector modalities in this tumor resolution. Antibody was not responsible for either tumor rejection or phthisis of the tumor-containing eye since passively transferred hyperimmune serum failed to produce either tumor rejection or the characteristic ocular lesions. Moreover, the destructive pattern of tumor rejection occurred in splenectomized hosts which had depressed anti-P91 serum antibody and in a congenic strain (B10-.D2oSn) lacking the C5 complement component. The likelihood that tumor necrosis factor (TNF) was involved in this pathogenesis was also ruled out by the observation that P91 tumor cells were not susceptible to lysis by recombinant TNF. A different pattern of tumor resolution was observed when the opposite eye was challenged with tumor. In this case, the tumor was rejected without damaging any major ocular structures. Histological analysis demonstrated a mononuclear cellular infiltrate which was identified by immuno-histology to be Thy 1+, Lyt 2+. Thus, although both forms of cell-mediated immunity are available to the host, only one predominated in each eye. These results suggest that unique immuno-logical control mechanisms influence the outcome of tumor resolution in the eye.

ISSN:0271-3683    

DOI:10.3109/02713688809031806

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

Handbook of ophthalmology. A practical guide. By Thomas W. Gardner and David E. Shock. Published by Prentice-Hall International, 1987.The polyol paradigm and the complications of diabetes. By Margo Panush Cohen. Published by Springer-Verlag, NY, 1987, 143 pp. with 25 figures and over 500 references.

ISSN:0271-3683    

DOI:10.3109/02713688809031807

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor