摘要:

The sensitivity to light-induced photoreceptor degeneration was examined in 7 different inbred strains of albino mice. The mice were exposed to 3 weeks of constant fluorescent light at an illuminance level of 115–130 ft-c (ca. 1,265–1,430 lux), after which the eyes were examined histologically. The degree of light-induced photoreceptor degeneration was compared to that found in BALB/cByJ (BALB/c) albino mice, which have previously been described as sensitive to the damaging effects of light, and to C57BL/6J-c2Jalbino mice, which have been shown to be resistant to light-induced damage. Mice of the A/J, AKR/J and NZW/LacJ strains were indistinguishable from BALB/c mice in light sensitivity, as measured by mean outer nuclear layer thickness and the presence or absence of outer segment membranes. Mice of the Ma/MyJ and RF/J strains were somewhat more sensitive to light than BALB/c mice, and those of the RIIIs/J were far more sensitive than all of the other strains. The LG/J strain differed from other strains by individual mice displaying one of two degrees of light sensitivity, those similar to the light-sensitive Ma/MyJ and RF strains and those remarkably more resistant to light, with photoreceptor outer segment integrity even greater than that of the light-resistant C57BL/6J-c2Jstrain. These findings demonstrate that different inbred strains of a given species may exhibit a wide range of sensitivities to constant light exposure and that most albino mouse strains examined thus far are highly sensitive to the damaging effects of light.

ISSN:0271-3683    

DOI:10.3109/02713688709034850

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

摘要:

Mussel Adhesive Protein (MAP) was applied to either denuded rabbit cornea, or dialysis membrane with a 50,000 dalton molecular weight cut-off. The permeability of corneal endothelium or bare stroma was compared with demambranized stroma coated on one surface with MAP. The permeability of dialysis membrane, both in the presence and absence of MAP, was also determined to inulin (5,000 daltons) and dextran (40,000 daltons). Corneal endothelial permeability was much less than that of bare stroma, and coating denuded stroma with MAP on one surface had no effect on stromal permeability. Dialysis membrane permeability was not reduced after coating with different thickness of MAP, indicating that MAP offers little resistance to the passage of even large non-electrolytes and can serve as a basement membrane for cellular or tissue attachment without impairment of nutritional supply to the overlying cells.

ISSN:0271-3683    

DOI:10.3109/02713688709034851

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

摘要:

Intravitreal Surgery: Principles and Practice By Gholam A. Peyman, M.D. and Joel A. Sohulman, M.D., Published by Appleton-Century-Crofts, Human Ophthalmic Pathology By O.A. Jensen Published by Munksgaard International Publishers, Ltd.Human Ophthalmic Pathology By O.A. Jensen Published by Munksgaard International Publishers, Ltd.

ISSN:0271-3683    

DOI:10.3109/02713688709034852

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor