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| 11. |
Corneal epithelial permeability after instillation of ophthalmic solutions containing local anaesthetics and preservatives |
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Current Eye Research,
Volume 7,
Issue 9,
1988,
Page 947-950
RamselaarJ. A.M.,
BootJ. P.,
Van HaeringenN. J.,
Van BestJ. A.,
OosterhuisJ. A.,
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摘要:
The effect of the local anaesthetics oxybuprocaine (OBu) and tetracaine (Tetra) and the preservatives chlorhexidine (CH) and benzalkonium chloride (BAK) on corneal epithelial permeability was studied by fluorophotometry in normal human eyes. Five instillations of one drop ophthalmic solution of the compounds were administered to one eye at 2-minute intervals; a control solution was instilled into the fellow eye.The increase in corneal epithelial permeability, expressed as the permeability ratio between the treated and control eye, was not significant after instillation of the anaesthetics. The preservatives and the combination OBu+CH increased corneal epithelial permeability significantly (P<0.05). OBu+BAK and Tetra+BAK increased permeability to a far greater extent (P<0.005).
ISSN:0271-3683
DOI:10.3109/02713688808997251
出版商:Taylor&Francis
年代:1988
数据来源: Taylor
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| 12. |
Appearance of collagenase in pneumolysin-treated corneal fibroblast cultures |
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Current Eye Research,
Volume 7,
Issue 9,
1988,
Page 951-953
JohnsonMary K.,
GebhardtBryan M.,
BermanMichael B.,
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PDF (264KB)
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摘要:
Sub-lethal levels of pneumolysin, a cytolytic toxin produced by the pneumococcus, have been shown to increase collagenase concentration in cultures of rabbit corneal fibroblasts. Interactions between pneumolysin and corneal cells may be involved in the pathogenesis of pneumococcal ocular infections.
ISSN:0271-3683
DOI:10.3109/02713688808997252
出版商:Taylor&Francis
年代:1988
数据来源: Taylor
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