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11. |
C-reactive protein in human lattice corneal dystrophy |
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Current Eye Research,
Volume 2,
Issue 10,
1982,
Page 721-724
RodriguesMerlyn M.,
RobeyPamela Gehron,
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摘要:
Lattice corneal dystrophy (LCD), an autosomal dominantly inherited disease, is characterized by a branching network of subepithelial and stromal amyloid deposits (1). Due to their small size and close association with stromal components and epithelial cells, their chemical composition is as yet undetermined. Amyloid deposits in other types of diseases have been found to contain amyloid P protein (AP). Serum amyloid P component (SAP) and C-reactive protein (CRP) resemble each other in molecular structure and amino acid sequence, but appear to be antigenically distinct (2–6). A humoral mediator most likely stimulates CRP release by hepatocytes and could be related to Interleukin-I synthesis from macrophages (4–6). Rabbit corneal epithelial cells also produced an Interleukin-I-like activity and contain a thymo-cyte activating cytokine (7). In this study, corneas from normal controls, primary LCD and recurrent LCD were fixed in formalin with ImM CaCl2and tested with antibodies to CRP, AP and AA (nonimmunoamyloid), using the inmunoperoxidase technique. The stroma of LCD and normal corneas did not stain with antibodies to AP, AA or CRP. However, we now report that antibodies to CRP show immunospecific binding to the corneal epithelium in primary and recurrent LCD.
ISSN:0271-3683
DOI:10.3109/02713688209020002
出版商:Taylor&Francis
年代:1982
数据来源: Taylor
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12. |
Erratum |
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Current Eye Research,
Volume 2,
Issue 10,
1982,
Page 725-725
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PDF (81KB)
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ISSN:0271-3683
DOI:10.3109/02713688209020003
出版商:Taylor&Francis
年代:1982
数据来源: Taylor
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