摘要:

SummaryA double-blind crossover study was designed to compare the anxiolytic properties of the benzodiazepines, lorazepam and diazepam, and to evaluate the principal side-effects prior to lorazepam's wider use in patients. Thirty patients with psychic or somatic symptoms of anxiety were given one active drug for a month, a placebo for 15 days and the other active drug for one month. Both lorazepam 1.25 mg. t.d.s., and diazepam 5 mg. t.d.s., alleviated anxiety to the same extent and gave a similar incidence of side-effects.Further use of lorazepam in a large number of patients has shown that most benefit from 1 mg. t.d.s. This dose could be increased progressively to 2.5 mg. t.d.s. It is suggested that lorazepam deserves particular attention since it is the most potent member of the benzodiazepine anxiolytics in clinical use.

ISSN:0300-7995    

DOI:10.1185/03007997309111683

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe use of lorazepam in the treatment of severe anxiety and anxiety associated with psychotic conditions is discussed. In general, high initial doses of lorazepam were used - between 10 and 40 mg. daily. Once anxiety was controlled, however, this could usually be reduced to a maintenance dosage of 7.5 to 10 mg. lorazepam daily. In many instances lorazepam may be usefully combined with antidepressant or neuroleptic drugs. The commonest side-effects seen with high dosage were drowsiness, hypotension and ataxia. However, in very severely anxious patients drowsiness which disappeared after a few days was thought to be a desirable effect at the beginning of treatment. It is concluded that either alone, or in association with other psychotherapeutic agents, lorazepam has a place in the symptomatic treatment of all states of anxiety and agitation.

ISSN:0300-7995    

DOI:10.1185/03007997309111684

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

ISSN:0300-7995    

DOI:10.1185/03007997309111685

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA pilot study on 18 gynaecological patients has indicated that oral lorazepam has distinct advantages over diazepam as a premedicant in general anaesthesia. The patient is tranquil but co-operative before the operation and welcomes the opportunity to avoid injections. She suffers less post-operative vomiting than with opiate premedication and has no unpleasant recall of events. The inevitable readjustment of the operating order presents no difficulty for nurse, patient or anaesthetist.

ISSN:0300-7995    

DOI:10.1185/03007997309111686

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

AbstractTwo studies are described, an open study on the degree of sedation produced by lorazepam and its effects on memory recall; and a double-blind study comparing lorazepam with heptabarbitone and diazepam. Overall, lorazepam has proved to be an interesting agent in premedication. It has many of the attributes of the narcotics -good sedation, good effect on memory recall and some post-operative basal narcosis which is of advantage in major operations. On the other hand, in the doses used it appears to have little effect on the cardiovascular system and is less likely to cause post-operative nausea and vomiting than the narcotic group.

ISSN:0300-7995    

DOI:10.1185/03007997309111687

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryLorazepam has been studied in 212 patients for use as a night-time sedative and for pre-operative medication. Sixty-four of the patients participated in an open pilot trial using lorazepam, and 148 patients formed part of a double-blind trial of lorazepam and diazepam. Each patient was given 2 mg. lorazepam the night before or 2 hours before surgery was anticipated.In the open trial, 68% of patients were asleep within 1 hour of lorazepam administration; only 14% required a repeat dose. The figures for the double-blind trial were 73% and 9% respectively. Over 90% had a continuous relaxed sleep. Muzziness the following morning was the commonest side-effect. The tranquillizing effect of lorazepam was noted following the pre-operative dose in 81% of patients from the double-blind trial and in 85%, of patients from the open trial. In addition, a soporific effect was produced for a period of 3 to 4 hours. The large majority (83%) showed no signs of catecholamine release.

ISSN:0300-7995    

DOI:10.1185/03007997309111688

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor