摘要:

SummaryDoxycycline (‘Vibramycin’), a broad-spectrum antibiotic active against a wide range of micro-organisms, was investigated in a clinical and laboratory trial involving 30 patients. The drug was administered in the form of capsules or syrup, at a dose of 200 mg. on the first day, followed by 100 mg. daily thereafter, or, in case of severe infection, 200 mg. daily. The duration of the treatment varied between 3 and 17 days, with an average period of 7.33 days.Excellent results were obtained in the majority of patients, who were suffering from a variety of staphylococcal infections. Impressive results were also observed in 2 cases of acute, and in the several cases of chronic urinary infections in the series. Most cases of acute and chronic respiratory infections in this series also responded well to doxycycline. Staph, aureus, A. aerogenes, enterococcus, E. coli, paracolonbacillus andklebsiella were shown to be highly sensitive to doxycycline. High blood and urinary levels of the antibiotic were observed during the study. No significant side-effects were noted during the course of treatment with doxycycline which proved a highly effective broad-spectrum antibiotic, both in vivo and in vitro.

ISSN:0300-7995    

DOI:10.1185/03007997309111706

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryTwo controlled double-blind trials comparing the efficacy of 'Hydergine' and identical placebo tablets in patients suffering from mild to moderate symptoms of cerebral arteriosclerosis or senile dementia are described. The initial crossover design with a crossover point at the eighth week produced equivocal results. However, these results were encouraging enough to proceed with a redesigned parallel-group study on a further 43 patients. Assessment was made at 4-week intervals using the 10 factor Crichton Royal Behavioural Rating Scale. Of the 43 patients taking part in the second half of this study, 15 in each group completed the 12-week period of treatment. The group treated with 'Hydergine' showed a greater improvement than those treated with placebo, this improvement being statistically significant (p<0.01).'Hydergine' appeared to be a safe drug, showing no marked side-effects. It is suggested that 'Hydergine' enhances cerebral metabolism through greater cortical enzyme activity and increased cerebral blood flow combined with a more efficient utilization of oxygen.

ISSN:0300-7995    

DOI:10.1185/03007997309111707

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA double-blind placebo controlled trial to evaluate the efficacy of 'Hydergine' in patients suffering from mild to moderate cerebrovascular insufficiency due to cerebral arteriosclerosis is described. A certain number of cases of senile dementia were inevitably included due to the difficulty in differentiating the two conditions. Of the original 58 patients, 26 in each group completed the 12-week study period. The 6 patients failing to complete did so for reasons not related to the drug under investigation. Assessment of 22 factors divided into 4 main symptom complexes was made at 4-week intervals for 12 weeks. Statistical significance in favour of'Hydergine'' was achieved in 3 of the 4 symptom complexes: Physical manifestations, p<0.01; Motor activity p<0.01; and Attitude and moodp<0.05, while in the Daily living activities complex p<0.1.The physician's overall assessment of the patients' progress showed that the improvement of the 'Hydergine' patient group was greater than the placebo group at the p<0.01 level of significance at the 4th, 8th and 12th week of treatment. 'Hydergine' was a safe drug showing no evident side-effects.

ISSN:0300-7995    

DOI:10.1185/03007997309111708

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThirty-nine patients with stabilized angina pectoris were selected and allocated at random to either lidoflazine or placebo treatment.Lidoflazine tablets each containing 60 mg. were matched with placebo tablets under double-blind conditions and the patients were given 1 tablet t.i.d.for the first 5 weeks and thereafter 2 tablets t.i.d. or less, according to either individual subjective improvement or side-effects, for 25 more weeks. Previously prescribed prenylamine was initially maintained in all patients. Dosage reduction took place according to individual subjective requirements.At the end of the trial, the comparison between lidoflazine and placebo patients revealed the following significant differences in favour of lidoflazine: improvement of social performance and working capacity (p=0.033); less need for prenylamine (p=0.013) and smaller 'optimum' daily dose of the double-blind medication (p=0.018); a more frequent improvement according to the global appreciation of the ST-T changes (p=0.0037), with an increase in the amplitude of the T-wave (p=0.0035) and a decrease in both J-point depression (p=0.0097) and negative ST-integral per sec (p=0.0097); increased (TI-TIII) and (TV6-TV1) (p=0.044 and p=0.00017 respectively); shorter P-waves and a lower Macruz' index (p=0.013 and 0.00017 respectively).There was no difference between both treatments as regards incidence and type of clinical and ECG side-effects, and changes in the investigated biochemical and haematological variables. Drug interactions, especially those between lidoflazine and prenylamine or anticoagulants, never occurred.

ISSN:0300-7995    

DOI:10.1185/03007997309111709

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA double-blind trial was carried out to compare the effects of 'Pitocin' (oxytocin) buccal tablets and a placebo on the unripe cervix. A series of 48 patients was examined before and after a course of 20 tablets given over a period of 71/2 hours. No significant difference was noted in the two groups.

ISSN:0300-7995    

DOI:10.1185/03007997309111710

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryFifty-seven patients suffering from acne vulgaris were treated for 12 weeks with 0.025% wjw retinoic acid lotion. At the end of this period, 55% of patients showed good to excellent clinical improvement, with 95% showing some overall benefit. The early lesions (comedones, papules and pustules) showed a marked reduction in numbers. Irritant side-effects were slight and did not present a problem.

ISSN:0300-7995    

DOI:10.1185/03007997309111711

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryDiethylpropion (‘Tenuate Dospan’) was found to be an acceptable therapy when given on a long-term basis to 20 very overweight patients who had failed to lose weight on diet alone. There were remarkably few untoward side-effects and no indication of the development of tolerance to the drug. An interesting feature of the trial was a correlation between fall in blood pressure with loss of weight.

ISSN:0300-7995    

DOI:10.1185/03007997309111712

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryPhentolamine (‘Regitine' Ciba), an alpha adrenergic blockade drug, was used in an acute study in various types of cardiac arrhythmias to evaluate its antiarrhythmic property. The drug was used in a dose of 0.5 mg. per min. 1.V.for 20 min. The drug was found to be of benefit in treating VPCs, VT and second degree heart block particularly associated with congestive heart failure. Supraventricular arrhythmias responded less favourably. No side-effects were recordedduring its clinicaluse. Phentolamine is a useful addition to the existing antiarrhythmic drugs.

ISSN:0300-7995    

DOI:10.1185/03007997309111713

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA personal over-view of the various postulated modes of action of the anti-inflammatory drugs is presented. Particular reference is made to the relevance of the individual findings to a clinical context. A critical review of the significance of uncoupling of oxidative-phosphorylation is presented. The numerous chemical mediators of the inflammatory response, including the biologically-active amines, kinins, prostaglandins, and cyclic AMP are discussed, and recent time course observations of the appearance of these substances on the scene in inflammatory reactions are reviewed. The all-embracing theory of the lysosomal membrane and enzyme involvement in the inflammatory response is critically discussed and comment is made on the possible role of other cellular enzymes, including hepatic microsomal enzyme and myeloperoxidase. Protein binding effects and the conjectured role of natural antiinflammatory substances is presented in relation to L tryptophan in rheumatoid arthritis. The relationships and roles of phagocytic cells and of the immunologically competent T and B cells in the inflammatory response are reviewed with particular reference to the action of some anti-inflammatory drugs upon these cells and upon the complement coagulation and fibrinolytic systems.

ISSN:0300-7995    

DOI:10.1185/03007997309111714

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor