摘要:

SummaryClindamycin (7-chlorolincomycin) was used successfully in the treatment of 3 patients with septicaemia caused by Bacteroides fragilis or related anaerobic Gram-negative bacilli. Bacteroides were isolated from 5 out of 324 blood cultures (1.5%) examined during 1972.Four of the patients were elderly and had undergone major abdominal surgery. It is suggested that, when such patients become pyrexial post-operatively, blood cultures should be taken as a routine procedure and the patients given comprehensive antibiotic treatment immediately. A combination of gentamicin and clindamycin (or parenteral lincomycin) should be satisfactory.

ISSN:0300-7995    

DOI:10.1185/03007997309111698

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryTwenty-six patients with acute exacerbations of chronic bronchitis requiring admission to hospital were treated with clindamycin 300 mg. or 450 mg. 6-hourly for 10 days to 3 weeks. Four were withdrawn because of side-effects. In 8 of the 22 completing the study, pneumococci were present in the pre-treatment sputum. With treatment, the organism was eradicated within 24 hours and in 5, the sputum became mucoid. All improved clinically although Haemophilus influenzae organisms were isolated at some stage from the sputum of all but one of these patients. Only 1 of the 14 whose sputum yielded predominantly haemophilus without pneumococci achieved sputum conversion, only 5 improved clinically and 3 deteriorated considerably in spite of intensive physiotherapy. Bacteriological eradication of Haemophilus influenzae did not occur when in vitro testing suggested sensitivity.It is concluded that clindamycin fails to eradicate Haemophilus influenzae from the sputum of patients with acute exacerbation of chronic bronchitis, irrespective of in vitro sensitivity. Its effectiveness in patients with pneumococcal and mixed pneumococcal infections suggests that the pneumococcus may be of primary pathogenic significance in such patients.

ISSN:0300-7995    

DOI:10.1185/03007997309111699

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryIt is suggested that drug formulations should be developed with some reference to the diurnal variations in the symptoms of the disease for which they are prescribed. The suggestion is examined with regard to hay fever. As a result, interesting epidemiological data for the United Kingdom has been obtained. Hay fever is complained of more commonly in social classes A, B and C and in those living in London or South-East England. It is less common in the elderly. The principle symptom is sneezing, followed by stuffy nose, red itchy eyes, wheezing and coughing, in that order. These symptoms are commoner in the forenoon and are also, in general, more severe during this period. The theoretical implications of the data are discussed in the context of drug formulations.

ISSN:0300-7995    

DOI:10.1185/03007997309111700

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryOxymetholone, a non-virilising androgen, active orally and known to have an active stimulant effect on the bone marrow, was given to an unselected group of 23 patients with various forms of malignant disease not suitable for surgery; in all but one it was given in conjunction with cytotoxic drugs. Although many of the patients were also receiving prednisolone the beneficial effect on the haemoglobin levels was striking and statistically significant. Twelve out of 23 patients (52%) showed a significant rise in haemoglobin level and when 3 patients are excluded, in whom no adequate assessment could be made, this proportion rises to 60%.It appears that oxymetholone is a useful drug for stimulation and protection of the bone marrow inpatients receiving cytotoxic therapy and is, therefore, a useful addition to the chemotherapy of malignant disease.

ISSN:0300-7995    

DOI:10.1185/03007997309111701

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA double-blind trial of reserpine and propranolol as adjuncts in the treatment of hyperthyroidism is described. Eighteen previously untreated hyperthyroid patients took part in the trial on an out-patient basis. Reserpine was given on an oral dosage of 0.25 mg. 4-times daily while propranolol was given on an oral dosage of 40 mg. 4-times daily; each drug was given for a period of 2 weeks. There was no significant difference in the effect of reserpine and propranolol on the symptoms, signs and certain investigations of hyperthyroidism. Two patients on reserpine complained of diarrhoea while 3 patients on propranolol had insomnia. It is concluded that the choice between reserpine and propranolol as an adjunct in the treatment of hyperthyroidism is dependent on their side-effects; bronchial asthma is the major contra-indication to propranolol while mental depression is the major contra-indication to reserpine.

ISSN:0300-7995    

DOI:10.1185/03007997309111702

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryForty-three patients with unilateral severe painful patellae, fulfilling the diagnostic criteria for 'chondromalacia patellae' laid down by Robinson and Darracott (1970), took part in a double-blind trial, 23 receiving an anabolic ester–nandrolone phenyl-propionate (‘Durabolin’). All patients followed a progressive quadriceps exercise programme. Twenty of the 23 patients given the anabolic ester were clinically improved. Changes in bone density in skyline knee radiographs were measured with a simple apparatus described.In 17 of the 23 patients given the anabolic ester, the bone density measurements improved. The 20 patients given the placebo showed an almost complete lack of response to the exercise programme alone. The possible aetiological factors involved in these results are discussed.

ISSN:0300-7995    

DOI:10.1185/03007997309111703

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryAfter initial stabilisation, flupenthixol decanoate injections were given to 134 outpatient schizophrenics over a period of 28 months. Thirty percent showed extrapyramidal side-effects and 8% severe depression. Persistent anergia and hypomania were also seen. There was a significant reduction in adapted Wing's scale scores over 6 months in the first 56 patients. Severe and unpredictable extra-pyramidal side-effects were less frequent than with fluphenazine, the relapse rate among aggressive paranoid schizophrenics tending to be higher with flupenthixol. Flupenthixol-treated patients seemed more active, sociable and able to communicate than phenothiazine-treated patients, which helped in their rehabilitation. No toxic effects were seen. Flupenthixol is considered to be an effective anti-psychotic and suitable for out-patient stabilisation and maintenance therapy.

ISSN:0300-7995    

DOI:10.1185/03007997309111704

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe available methods of evaluation of an antirheumatic compound in a clinical trial situation are discussed. The techniques of single-blind and double-blind studies are described and their respective merits analysed. Proposed new techniques for the measurement of joint inflammation are reviewed.

ISSN:0300-7995    

DOI:10.1185/03007997309111705

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor