摘要:

AbstractThe biological compatibility of polypyrrolidone was investigated using subcutaneous implantation in rats. Acute (10 days) and chronic (360 days after implantation) tissue reaction was characterized numerically and compared with poly(2‐hydroxyethyl methacrylate), used in the Drug Control Research Institute in Prague as a standard in the evaluation of polymers, for which good tolerance in the clinical practice has been demonstrated. Surface changes in the polymer were evaluated by using a scanning electron microscop

ISSN:0021-9304    

DOI:10.1002/jbm.820160202

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

摘要:

AbstractManagement of the chronically instrumented animal is improved by enclosing the terminations of catheters and transducer wires in a subcutaneous nylon velour pouch. Six or more days after implantation, an opening is made into the pouch by removing a portion of the overlying skin; subsequent healing processes provide a satisfactory bond. Thereafter the leads can be extracted and replaced without need for anesthesia or dissection. Results in 35 animals (26 dogs and 9 monkeys) for intervals up to four months showed fibrous encapsulation was complete in 28 and partial in 7, with no mortality or significant morbidity attributable solely to the presence of the pouch. Gross and microscopic tissue examination indicated a localized foreign body reaction in response to the nylon fibers. The technique is especially useful in experimental protocols for which continuous restraint is undesirable, such as the chronically instrumented primate periodically exposed to environmental stress.

ISSN:0021-9304    

DOI:10.1002/jbm.820160203

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

摘要:

AbstractThe pH effect on the hydrolytic degradation of Polyglactin 910 copolymer was studied in terms of the tensile properties of the suture specimens. The use of a cord/yarn grip, newly designed specifically for fibrous materials, eliminated the grip‐induced failure. Different degrees of hydrolytic degradation of this copolymer at 3 different pH levels were observed. The suture specimens exhibited the best retentions of breaking strength at the physiological pH of 7.44, while the specimens at pH = 10.09 showed the fastest loss of breaking strength. Thus, a maximum retention of tensile properties occurred around the pH level of 7.0, whereas smaller percentages of retention of tensile properties were observed at both acidic and strong alkaline solutions. This synthetic absorbable suture material exhibits the basic characteristic of hydrolysis which is catalyzed by both acid and bas

ISSN:0021-9304    

DOI:10.1002/jbm.820160204

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

摘要:

AbstractThe corrosion of the pure metals aluminium, cobalt, copper, chromium, molybdenum, nickel, and titanium and of a cobalt‐chromium molybdenum casting alloy has been studied in buffered saline with and without the presence of the proteins serum albumin and fibrinogen. The corrosion of aluminium and titanium was unaffected by the protein. The corrosion rates of chromium and nickel showed a slight increase, while cobalt and copper dissolved to a very much greater extent in the presence of protein. However, with molybdenum the corrosion was inhibited by protei

ISSN:0021-9304    

DOI:10.1002/jbm.820160205

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

摘要:

AbstractThe setting reaction of six dental materials has been studied by using a water dilatometer at 25° and 37°C. Where there is no water absorption during the test, the method gives reproducible values of the setting shrinkage and at the same time shows a clear physical picture of the entire setting process. This method is suitable for adaptation as a specification test for setting shrinkage and has good potential for being used as a supplementary or substitute test for initial and final set time

ISSN:0021-9304    

DOI:10.1002/jbm.820160206

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

摘要:

AbstractAn investigation was carried out into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from a cold cured acrylic denture base material. The drugs were added at 10% w/w with the powder phase of the material. Water, at the concentrations of 10%, 20%, and 30% of the monomer phase of the material was added to chlorhexidine‐containing and chlorhexidine‐free samples. Spectrophotometric and bioassay measurements of the release of chlorhexidine demonstrated protracted delivery to 140 days. The daily release rate was increased by the addition of water to the material and at 30% water incorporation the release was greater and increased up to 190 days. The release pattern of prednisolone sodium phosphate was similar to that of chlorhexidine without the addition of water. Prednisolone alcohol was released for a much shorter period and at lower levels. Scanning electron microscopic examination of the polished, etched, and fractured surfaces of the material demonstrated that chlorhexidine acetate and prednisolone sodium phosphate were incorporated into the interbead matrix areas of the material. The irregularities in the material increased with the addition of water. Prednisolone alcohol produced minimal changes in the specimens except after soaking in water for 140 days when numerous small defects could be seen in the matrix zones at high magnification. The use of materials such as water to increase porosity appears a simple method of improving the release pattern of drugs from acrylic. However, the strength of the resulting material would require support from an existing intraoral prosthesis or applia

ISSN:0021-9304    

DOI:10.1002/jbm.820160207

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

摘要:

AbstractBiomaterials as a class includes a wide variety of both artificial and natural materials. The discipline of Biomaterials must be recognized as the study of the materials aspects of both fabricated materials and natural tissues, as well as their interactions. Emerging disciplines give rise to academic establishments. A survey of 97 U.S. and Canadian universities reveals a wide range in institutional settings and course offerings in Biomaterials. Plans for faculty additions suggest that the field is still actively expanding.

ISSN:0021-9304    

DOI:10.1002/jbm.820160208

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

ISSN:0021-9304    

DOI:10.1002/jbm.820160209

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

ISSN:0021-9304    

DOI:10.1002/jbm.820160210

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY

ISSN:0021-9304    

DOI:10.1002/jbm.820160211

出版商:John Wiley&Sons    

年代:1982

数据来源: WILEY