摘要:

AbstractAn automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide‐2‐mononitrate, isosorbide‐5‐mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human plasma is described. The procedure involves the extraction of the drug and its metabolites together with their internal standards isomannide dinitrate ando‐nitrobenzyl alcohol from plasma with dicholromethane.The analysis is carried out by fused silica capillary gas chromatography using a63Ni‐electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrat

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe possibility of high‐speed micro‐HPLC has been investigated using a short micro‐column (35 mm × 0.5 mm i.d.) packed with 3 μm ODS particle. The results indicate that this approach has considerable potential for good separations with short analysis time. A typical example shows only three minutes is required with a plate count of 3,800 to separate sev

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractGas chromatography (GC) with electron capture detection (ECD), GC combined with mass spectrometry (MS), GC with multi‐stage mass spectometry (MS‐MS), and direct inlet MS‐MS have been used to determine 1,1‐dichlorodimethyl sulfone (DDS) in aquatic organisms in the receiving waters outside a pulp mill bleach plant. Both GC‐MS‐MC and direct inlet MS‐MS of tissue extracts of fish and mussel appear to be sensitive, selective, and rapid analytical techniques for the determi

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA method is described which allows the determination of different substituted polycyclic aromatic hydrocarbons (PAH) such as NO2‐PAH, carbazoles, keto‐PAH, and aza‐arenes in aerosol samples. Liquid CO2‐extraction is used to minimize the loss of reactive compounds. High performance liquid chromatography on chemically activated silica is employed to prefractionate the samples into subfractions with a minimum of overlap between different PAH compound classes. Both electron capture detection and negative ion chemical ionization combined with capillary gas chromatography are used for identification and quantification. The latter method also allows distinction between isomers with different toxic properties when N2O/CH4reaction gas mixtures are used. Selectivity for tetrachlorodibenzo‐p‐dioxins as against pesticides and polychlorinated biphenyls can be improved by this technique. The applicability of the method is critically discussed and different example

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractComplex organic mixtures, such as coal liquefaction and oil shale products and by‐products, are comprised of hundreds or thousands of individual components. State‐of‐the‐art high resolution gas chromatography does not always provide sufficient resolution to allow accurate quantitation or identification of many compounds of interest. The concept of dual capillary column chromatography combines the different resolving characteristics of two capillary columns coated with different stationary phases into a single chromatographic run. In this approach, both columns are connected to the same injection port. Analysis of complex mixtures in this fashion can confirm the identification and quantitation of components on two columns of different polarity with little increased analysis time, can provide a means of obtaining quantitative data for individual components which are known to coelute on any one column, and can alert one to unknown coelution problems that would be undetected by gas chromatographic analysis on a single capillary column.Simultaneous dual column analysis was applied to three samples, the neutral polycyclic aromatic hydrocarbon (PAH) fraction of a Solvent Refined Coal‐II (SRC‐II) heavy distillate, the nitrogen‐containing polycyclic aromatic compound (N‐PAC) fraction of an SRC‐II heavy distillate, and the basic fraction from a shale oil process water. Fused silica capillary columns coated with SE‐54 and Durawax 3 were used for the analyses of the heavy distillate, while SE‐54 an Carbowax 20M capillary columns were used for the analysis

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractMethyl‐2‐phenylethylpolysiloxane polymers have been synthesized for comparison with methylphenylpolysiloxane stationary phases for gas chromatography. The 50% 2‐phenylethyl polysiloxane was found to be autocrosslinkable at 260°C without addition of free redical initiator. Although the selectivity of this phase appears to be similar to the 50% phenyl polysiloxane, its thermal stability is not a

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0935-6304    

DOI:10.1002/jhrc.1240070211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY