摘要:

AbstractWe studied laser suture lysis of subconjunctival scleral sutures in a rabbit eye using selected wavelengths from a dye and diode laser to determine which wavelength caused the least conjunctival damage. We found an oval shaped area of coagulation necrosis surrounding the suture track in the conjunctival substantia propria measuring in depth 61.0 μ for 488 + 514 nm (blue‐green), 105.7 μ for 514 nm (green), 148.3 μ for 630 nm (red), and 29.0 μ with 780 + 830 nm (infrared) wavelengths. No observable damage was noted with 585 nm (yellow) or 610 nm (orange) wavelengths. The energy intensity required for suture lysis was similar across each wavelength studied. No damage was observed in the sclera or conjunctival epithelium. These findings suggest that using the yellow or orange wavelength, when performing laser suture lysis clinically, potentially may limit conjunctival d

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04883.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractOcular protrusion and lateral interorbital width were measured in 462 patients; 187 females and 275 males ranging in age from 9 to 92 years. The object of this study was to determine if ocular protrusion, asymmetry of protrusion and lateral interorbital width was dependent upon age. There was a significant reduction in ocular protrusion and lateral interorbital width with increasing age in both females and males. There was a strong correlation between ocular protrusion and lateral interorbital width. Asymmetry of ocular protrusion did not develop with age. These findings may help in the longitudinal assessment of patients.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04884.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractWe performed the anterior chamber tube shunt to an encircling band procedure in 34 patients (36 eyes) with refractory glaucoma, and evaluated the long‐term outcome. The preoperative mean intraocular pressure (IOP) was 36.8 ± 9.6 mmHg, the postoperative mean IOP was 21.6 ± 13.6 mmHg, a statistically significant (p<0.01) reduction of IOP following this procedure. The final postoperative IOP was under 21 mmHg in 23 (63.9%) of the 36 eyes. The success rate of IOP control 36 months after the operation without any elevation of postoperative IOP was 30.3% (life‐table method). Complications of this procedure included flattening of the anterior chamber (61.1%), damage to the corneal endothelium (25%), hyphema (25%), and a transient IOP elevation (25%). As filtering surgery with 5‐fluorouracil is more effective and simple to perform, we conclude that the anterior chamber tube shunt to an encircling band procedure should be reserved for those with refractory glaucoma who have had multiple surgical interv

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04885.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractIntracellular pH (pHi) of cultured bovine trabecular cells was measured using video‐imaging techniques with a pH‐sensitive intracellular fluorescent dye, BCECF. In bicarbonate‐rich Ringer at pH 7.4, pHiwas 7.29 ± 0.03 (± SEM, n = 12 monolayers, 120 cells sampled). Exposure to 20 mM NH4Cl immediately alkalinized pHi: replacement with a Na+‐rich solution acidified pHibefore recovery to resting levels. When NH4Cl was replaced by a low Na+solution, acidification was sustained but pHirecovery occurred after Na+‐rich solution. A pHiof 7.11 ± 0.02 (n = 2 monolayers, 20 cells) occurred in pH 6.8 and pHiwas 7.72 ±0.03 (n = 2 monolayers, 20 cells) in pH 8.0. Amiloride (1 mM) acidified pHibut DIDS (1 mM) treatment, HCO3−‐free condition, 1 mM ouabain, 50 mM K+, and 2 mM BaCl2failed to change pHi. Hydrogen peroxide (1 mM) acidified pHibut no change occurred with 50 μM. Trabecular cells possess an Na+/H+exchanger similar to that i

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04886.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractNineteen patients with malignant uveal melanomas were treated with I‐125 applicators. There were 10 males and 9 females with a median age of 61 years (range 42–76). The tumour was located in the choroid in 12 eyes and in the choroid and ciliary body in 7 eyes. The size of the tumours was 7–18 mm in maximal basal diameter (median 12), 5–16 mm in minimal basal diameter (median 10), and 5.5–15 mm in thickness (median 8.5). The volume of the tumours was 123–1890 mm3(median 540). All tumours were classified as large (T3). For the irradiation, a computer program, which calculates three‐dimensional dose distribution of I‐125 seeds in gold plaques, was developed. By modifying the seed positions, activity and the orientation, patients can be treated individually. Iodine‐125 emits low energy photons, ideal for intraocular tumour therapy and tissue. Extra‐ocular tissue located behind the applicator can be completely shielded by a 0.5 mm gold layer. The dose at the apex of the tumour ranged from 30 to 120 Gy (median 93). The treatment time ranged from 44 to 600 h (median 235). Preliminary results are good. After a median follow‐up of 6 months, the tumour growth has been arrested in all eyes and in 10 eyes the tumour

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04887.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractHLA B5 plays an important role in the aetiology of Behçet's disease. The frequency of HLA B5 differs between racial groups and geographical regions. Ocular involvement, which could lead to serious complications, is a very important feature of Behçet's disease. Various racial groups having different genetic properties live in the Čukurova region, located in southern Turkey. To investigate the role of HLA B5 in Behçet's disease in Čukurova region, HLA B5 antigens were investigated by lymphocytotoxicity assay in 65 patients and 200 healthy controls. A significantly higher frequency was found in the patient group. Neither ocular involvement, nor the type of uveitis showed any correlation with HLA B5, but it was found that patients presenting with frequent ocular attacks had significantly higher HLA B5 positivity than the patients with rare attacks. This observation suggests that HLA B5 would be a negative factor in visual prognosis in Behçet's di

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04888.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe current investigation was designed to determine the total serum sialic acid (TSA), lipid associated sialic acid (LASA), total protein (TP), and TSA/TP values for 16 patients with active form of Behçet's disease, 12 patients with other uveitis types (pathologic controls) and 22 normal individuals. Data analysis indicated significant differences in mean TSA, LASA and TSA/TP values in patients with Behçet's disease (95.6 ± 15.3 mg/dl, 29.8 ± 7.4 mg/dl and 12.9 ± 2.1 mg/g, respectively) and in pathologic controls (75.8 ± 8.1 mg/dl, 26.6 ± 0.3 mg/dl and 10.0 ± 0.9 mg/g, respectively) when compared to normal controls (59.5 ± 7.5 mg/dl, 19.2 ± 3.2 mg/dl and 8.2 ± 0.9 mg/g, respectively) (p0.05). A statistically significant difference was observed between the patients with Behçet's disease and pathologic controls with respect to TSA, TSA/TP values (p<0.01). The results indicated that TSA and TSA/TP is most useful for differentiating Behçet's disease from other

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04889.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractToxoplasma infection is a common cause of infectious uveitis. It usually produces a characteristic fundal appearance, with evidence of previous inflammation. However, it may occur in an atypical and aggressive form. Steroids administered to salvage vision may then worsen the clinical course. Retinal biopsy may be diagnostic in cases where doubt exists. We illustrate these points with two cases.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04890.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractAn ophthalmic status is given for 95 consecutive patients referred from other departments of the Central County Hospital 1986–88 due to suspected giant cell arteritis. Eventually, the diagnosis was confirmed in 51/95 (18 had positive biopsy of the temporal artery; in 33 it was on clinical grounds). Nine of the 51 had significant visual loss, in one even as bilateral blindness. Generalized malignancies were found in 2 of the 44 with diagnosis other than giant cell arteritis. Retrospectively, in the same 3‐year period a total of 263 cases of giant cell arteritis were registered in the somatic hospitals of the county (population 340 000). One further case with visual loss became known from requests to the primary health sector ophthalmologists. Between 3–4% were thus known to have significant visual loss, a result mainly in keeping with other Nordic clinical studies. Probably, the low figures of visual impairment are related to high diagnostic rates of giant cell arteritis, and to early treatment. Our hospital‐based data of giant cell arteritis gave a calculated annual incidence of 1 per 1000 of those older than 50 years in the county, or 27/100 000 including all ages. ‐ The true county incidence would be even higher had it been possible to find and include the additional cases of giant cell arteritis who were diagnosed and treated in the primary health se

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04891.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe ultrastructure of the lens capsule remnants in an eye with known fibrillopathy (pseudoexfoliation/exfoliation syndrome) subjected to an extracapsular cataract extraction (ECCE) and lens implantation 11 months earlier was examined. Lens epithelial changes typical in lenses with fibrillopathy were observed. The well‐known fibrils radiated from pits in the lens epithelial cells, forming a deep layer in the lens capsule and the Busacca bushes on the capsule surface. It thus appears that the production of fibrillar material from lens epithelium may continue after ECCE and implantation of an intraocular lens. A possible connection between intracellular and extracellular fibrils was notice

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb04892.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY