摘要:

AbstractKnowledge of the probability of having glaucoma at different levels of eye pressure is a prerequisite for estimating at which eye pressure levels preventive pressure‐lowering treatment ought to be applied. The glaucoma tolerance may not be the same in all population groups. Calculation of tolerance distribution curves may be performed if the frequency distribution curves of pressure in eyes with and without glaucoma are known. Regression analysis has been performed to compute curves approaching the cumulative frequency distribution of the eye pressure in different subgroups. Results of a population study including subjects ≥ 65 years of age have been used. An equation describing an asymmetric sigmoid curve has been applied in the curve fitting procedure. The derivative of this equation was used to describe the noncumulative frequency distribution curves. The analysis has been performed in subgroups consisting of normal eyes, glaucomatous eyes, eyes with and without pseudo‐exfoli

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02119.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractDuring the period 1970–87 we evaluated the changes of the optic disc, peripapillary area, detached macula and visual acuity in 16 cases with congenital pit of the optic nerve and macular detachment. The study revealed in 9 of the 16 cases (56%) an increase of the dimension of the pit or changes in its color, findings which were directly related to the duration of the macular detachment. Chorioretinal scarring, pigment migration, or both, were also noted mainly at the temporal margin of optic disc. In 5/16 cases we found during the follow‐up an extension of macular elevation. In altogether 10 out of 16 cases the retinal elevation covered the larger portion of the mid‐periphery temporally. In 7/16 cases the final visual acuity remained unchanged, in 9/16 cases deteriorated. The difference, however, in the latter 9 cases between initial and final visual acuity was negligible. During the follow‐up period deterioration of the visual fields was als

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02120.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe polyamines putrescine, spermidine and spermine are essential for normal cell function and proposed to be involved in inflammatory reactions. The polyamines were measured bilaterally in rabbit aqueous humor after unilateral endotoxin‐induced uveitis. The contralateral eyes were injected with saline or not touched. Aqueous protein levels and leukocytes were determined and a histological evaluation was performed. Protein, leukocytes, putrescine and spermine increased in the treated eyes, but not in the untouched eyes. When saline was injected in the contralateral eye, a small increase in spermine was seen. Spermidine decreased first, but increased later, in both the endotoxin‐injected and the other eye. Histopathologically, the treated eyes showed an infiltration of leukocytes, vasodilatation and in some cases optic nerve involvements. A mild reaction was also seen in the unchallenged contralateral eyes. The results show that polyamines might serve as a marker for acute inflammation in the eye and that the mechanism of putrescine and spermine induction is different from the one of spermidine. Polyamines are suggested to play a role in the cellular immune respo

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02121.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractSerum alpha‐1 acid glycoprotein levels were measured in 27 patients with idiopathic peripheral retinal vasculitis (Eales' disease) and 31 healthy subjects by single radial immunodiffusion technique. The levels were found to be significantly increased in both moderate and severe types of the disease. The serum levels of this protein paralleled the severity of the disease. The increased alpha‐1 acid glycoprotein in serum showed a significant fall to near normal levels during the quiescent stage. Our observations support the hypothesis that idiopathic peripheral retinal vasculitis is an immune mediated disease. It is proposed that serum alpha‐1 acid glycoprotein may be considered as a reliable parameter of the activity and the degree of severity of the disease, as well as an useful tool for monitoring the efficacy of trea

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02122.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractWe have studied the effect of the aluminum complex of sucrose sulphate (Sucralfate suspension) and the sodium salt of sucrose sulphate (sodium sucrose sulphate solution) on patients with keratoconjunctivitis sicca. Eyes treated with either of these two drugs showed a decrease in painfulness and blurring of vision. On examination the surface area of the corneal lesions, stained with fluorescein, diminished during treatment. As for the difference in effect between the two eyedrops, the solution was better tolerated.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02123.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractFifty‐six patients who underwent extracapsular cataract surgery were randomized in two groups with 28 patients in each group. Group 1 was treated with standard preoperative dilation regime and group 2 received in addition indomethacin 1% ophthalmic solution. Horizontal and vertical pupil diameter measurements were taken before capsulotomy, before exprimation of the lens nucleus and before lens implantation. The size of the pupil at the time of capsulotomy and at the time just before lens exprimation was greatest in the non‐indomethacin treated group, but at the time of lens implantation the pupil of the indomethacin treated group was greatest. It is concluded that even though indomethacin seems to be able to inhibit surgically induced miosis, probably through its inhibitory effect on prostaglandine synthesis, the effect is only marginal and from a clinical point of view it cannot be recommen

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02124.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe CDG syndrome is a newly detected disorder with a carbohydrate defect in glycoproteins such as transferrin. As retinitis pigmentosa is a part of this syndrome, there could also be other subtypes of retinitis pigmentosa with a similar biochemical defect. Isoforms of serum transferrin were therefore analysed in 78 patients from different families with retinitis pigmentosa and showed slightly or moderately elevated values for less glycosylated isoforms in two families. The study suggests that abnormal glycoprotein metabolism manifested by elevated values of carbohydrate‐deficient isotransferrins may be present in a small proportion of families with retinitis pigmentosa. The relationship between the glycoprotein defect and retinitis pigmentosa remains to be establishe

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02125.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractA 29‐year‐old former drug addict with candida albicans endophthalmitis determined by cultivation was treated with vitrectomy and systemic fluconazole. The infection resolved completely and the patient recovered a visual acuity of 6/6. Fluconazole was well tolerated and a high concentration was found in the vitreous cav

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02126.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractPrimary experience with the use of eximer laser in pterygium therapy is presented. Twenty‐two pterygia (11 primary and 11 recurrent) were surgically removed using the bare‐sclera technique followed by excimer laser ablation to smoothen the corneal surface. As recurrence was observed in 20 eyes (91%) during the first year, supplementary excimer laser treatment of a pterygium does not seem to reduce the recurrence rate. The high recurrence rate in this series may to a certain extent reflect the surgical technique used (bare‐sc

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02127.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractA 63‐year‐old man, who had for one month been on sulfasalazine therapy, developed general malaise, high fever, severe stomatitis, and bilateral necrotizing pseudomembranous conjunctivitis with corneal erosion, identical to that seen in the Stevens‐Johnson syndrome. Topical therapy with antibiotics and aprotinin rapidly healed the corneal surfaces, while densely adherent true membranes developed on the conjunctiva, and were removed surgically several times during the next week. After the acute stage, subtle subepithelial conjunctival scarring, superficial punctate keratitis, dry eye syndrome and fluctuating irregular corneal astigmatism became evident, but good visual acuity, lid function and ocular motility were retained. Histopathologic study of conjunctival membranes from two cases of membranous conjunctivitis revealed polymorphonuclear leukocytes within a matrix composed of fibrin, tenascin and fibronectin. In older membranes, histiocytes were additionally found. Surgical debridement of such membranes removes a substratum of inflammatory debris that is likely to promote secondary infection, fibrosis and symblepharon formation, and may decrease rather than increase subsequent scarring of the necrotized conjun

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1992.tb02128.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY