摘要:

A prospective long‐term study of the predictive value of the oscillatory potential in the development of proliferative diabetic retinopathy has been made in 137 diabetics. Follow‐ups 6–8 and 13–15 years later demonstrated that recording the oscillatory potential in juvenile diabetics with a disease duration of more than 5 years is valuable in selecting those at risk of developing proliferative retinopathy within 6 years at any rate. The predictive value of the oscillatory potential is probably more limited in women who later become p

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08312.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The study draws a comparison between the oscillatory potential of the electroretinogram and the initial dark‐adaptation measured by nyctometry, with the aim of assessing the predictive value of nyctometry in juvenile diabetics. The study included 61 insulin‐dependent juvenile diabetics, aged 18–49 years, with a disease duration of more than five years. A statistically highly significant correlation could be demonstrated between alterations in the oscillatory potential and the initial dark‐adaptation. The results justify the assumption that nyctometry can be used as an easily handled clinical tool in selecting those at risk of developing proliferative retinopathy in their subsequent 6

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08313.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A report is given on refractive change (Δ R) from age of 10 to 18 years. The 1979 follow‐up comprises 137 persons who had earlier (around 1970) participated in a larger investigation into ophthalmic sequels to a low birth weight (n = 539).In general (127 out of 137), there is a shift towards lower dioptric values (increase in refraction). Seven remained static while three showed a slight decrease in refraction (0.25–0.5 D).Adult emme‐ and hypermetropia show a median Δ R about 0.7 D (increase) during adolescence, against median values of 1.7 and 2.5 D in juvenile myopia, of ex‐prematures and full‐terms respectively. With a median Δ R of 1.2 D, ‘myopia of prematurity’ occupies an intermediate position (21 eyes of 13 subjects). Except for this subgroup, there is no evidence that low birth weight has influenced refractive distribution.With a (planned) skewing towards myopia, the 1979‐sample cannot be considered epidemiologically representative, as was the original 1970‐material. Concerning the latter, the 18‐year incidence of myopia is given as 17.6% for ex‐prematures and 13.1% for fullterms (minimum figures, based on

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08314.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A defect in the blood‐retina barrier in the optic nerve head region has been demonstrated. In order to show the exact localization of this defect, an in vitro experiment has been performed on rabbit eyes, using horseradish peroxidase as a tracer. From a subretinal depot the tracer diffused between the innermost retinal pigment epithelial cell and the cells of Kuhnt intermediary tissue into the border tissue of Elschnig and the juxtapapillary choroid.The defect in the permeability barrier is thus located to the junction between the retinal pigment epithelium and the Kuhnt intermediary tissue. The role of the junctional complexes in the Kuhnt intermediary tissue in relation to the blood‐retina barrier is discus

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08315.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Macular disturbances in patients with active idiopathic central serous retinopathy can be readily documented by performing Amsler charting or static perimetry, but, as uncertainty exists as to which examination technique is superior for detecting disturbances after a detachment has settled, a study was performed in which patients were investigated by the two methods during the acute, resolving and resolved stages of the disease.All of the patients assessed in the acute phase showed abnormal responses to both forms of examination, but after the oedema fluid absorbed 63% of cases retained abnormal static profiles whereas 81% recorded defects on Amsler charting. Disturbances of retinal function were most apparent on static perimetry testing if the meridian studied corresponded to that intersecting the site at which the focal breakdown of the choroidoretinal barrier had developed and the fovea. The incidence of retinal changes was found to be greater in patients where the oedema resolved slowly.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08316.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Visual field testing with the Competer fully automatic computerized perimeter (Heijl&Krakau 1975) employing a supra‐liminal screening test procedure was used in a material of 1013 eyes with ocular hypertension in which earlier routine perimetry (kinetic and static) on the Goldmann perimeter had yielded a normal result. The automatic screening was repeated if positive, and manual control perimetry was used in order to confirm or reject identified field defects. This procedure revealed field defects that could be confirmed at both automatic and manual perimetry in 3.6% of the eyes. In a control group the incidence of field defects found at manual perimetry during the same time interval was calculated at 0.4%. Thus automatic screening revealed several times more field defects than manual routine perimetry. Eyes in which repeated automatic screening had indicated defects which manual control perimetry failed to confirm, showed a high percentage of field loss at later follow‐up. The results are discussed, and the conclusion is drawn that automatic screening is clearly superior to manual routine perimetry used at present. The most practical solution in many eye departments would be to use a computerized perimeter for the visual field screening of glaucoma suspe

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08317.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Transient and steady state VER's before and after artificial IOP elevation were recorded from 16 eyes (9 persons) with untreated intraocular hypertension observed for several years without signs of functional loss or optic disc changes. Four eyes (two patients) demonstrated a pathological transient VER amplitude drop after pressure increase. One eye with an ophthalmoscopically atypical disc presented a grossly deformed transient VER at the habitual pressure level; the fellow eye was lost from trauma. Another eye presented an abnormal VER pattern and showed as yet normal function and ophthalmoscopy, the fellow eye had developed open angle glaucoma and showed identical VER changes. The prognostic and diagnostic implications are briefly discussed.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08318.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The effects of the long‐acting pilocarpine preparation, Ocusert®, were studied by its application for one week into a total of 52 eyes of 42 earlier untreated glaucoma patients. From the diurnal pressure curves it was found to be equivalent to three daily administrations of 2 or 4% pilocarpine topically, the experiences were as follow: 8 of the preparations had to be removed before the end of the experiment due to insufficient effect and two were removed for other reasons; 19 fell out accidentally, 3 were displaced so as to be visible occasionally under the eyelid, but did not fall out; 2 patients succeeded in replacing the preparation after it had fallen out. In the 19 eyes (37%) of all patients still in the trial after the first day, the preparations stayed in place without any difficulty for the whole week. All patients experienced minor side‐effects, but only one of them terminated the treatment due to these side‐effects. Serious side‐effects did n

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08319.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Thirty‐eight patients with ocular hypertension or glaucoma were treated with topical timolol for 12–30 months (mean 20). A long lasting hypotensive effect of timolol eyedrops was found. However a need to increase therapy during the follow‐up period was noted especially in the glaucoma group. Eyes with pseudoexfoliations often required concomitant therapy from the beginning. Ocular side effects were relatively few but four cases of punctate keratitis and another two with decreased corneal sensitivity were obs

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08320.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

281 eyes out of 330 were followed during 3 to 5½ years after trabeculectomy. 32 eyes were drop‐outs due to death and 17 eyes due to inability to participate in the examination program. The mean age at time of surgery was 66 years. A mean pre‐operative IOP of 31 mmHg dropped to a mean post‐operative level of 18 mmHg. In 57% a single trabeculectomy was considered enough to control the glaucoma. Post‐operative medical treatment was considered necessary in 35%. In 87% the pre‐operative progress of the field defect was arrested. A reoperation was performed in 8%. The early complications were very few, but in 25% a slowly developing cataract was observed. A cataract extraction was performed in 29 eyes post trabeculectomiam with a favourable visual outcome. This study confirms the opinion that trabeculectomy is an atraumatic and efficient surgical procedure and a necessary therapeutic measure when the tolerable combination of antiglaucoma drugs proves insufficient to control th

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1980.tb08321.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY