摘要:

Abstract.Fortynine patients were included in a controlled clinical trial comparing the effect of topical nonsteroid versus potent steroid preparation in acute anterior non‐granulomatous uveitis. Twentyfive patients were randomized to 1% Indometacin and 24 patients to 0.1% Dexametason treatment 6 times a day. There was no difference between the two groups initially. After 7 days of treatment we found significantly less inflammation in the steroid treated group, this significant difference disappearing on day 14. We conclude that whenever adverse reactions to corticosteroid eye drops are suspected or proven, Indometacin eye drops make up a useful alternative to even strong solutions of steroids. The study was carried out in the following practices: L. Ahrendt, L. Damgård‐Jensen, P. Eldrup‐Jørgensen, J. Elmeros, H. Heuer, S. Jensen, M. H. Kjeldsen, P. Nellemann Sørensen, H. Petersen, N. Vede

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02703.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.We examined immunohistochemically the localization of three transport enzymes (carbonic anhydrase, Ca‐II; sodium‐potassium‐activated adenosine triphosphatase, NaK‐ATPase; bicarbonate‐chloride exchanger, band III) in the anterior segment of the human eye. In accord with earlier studies, NaK‐ATPase was primarily found in the corneal endothelium, but also in the corneal basal epithelial cell membranes. In addition, immunoreactivity for NaK‐ATPase was observed in the non‐pigmented epithelium of the ciliary processes and between the two epithelial cell layers. Ca‐II immunoreactivity was found in the corneal endothelium as well as in the non‐pigmented epithelial layer of the ciliary processes. Interestingly, band III immunoreactivity was found in the corneal endothelium, as similar to Ca‐II, but not in the ciliary processes. These results show that, similar to many other tissues, Ca‐II and band III immunoreactivities colocalize in the same cytologic site in the human corneal endothelium. Immunocytochemical detection of these key transport enzymes not only gives their accurate and reliable anatomical distribution, but also provides information on the electrolyte t

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02704.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.All 3 children, 2 boys and 1 girl (the probands), in a family had high myopia and subnormal visual acuities. The boys had high myopia in both eyes, the girl had high myopia in 1 eye and low myopia in the other eye. Both of the boys had a protanomalous colour vision defect. The colour vision testing of the high myopic eye of the girl was not successful, the other eye had normal colour vision. In the electroretinogram examination, both cone and rod responses were decreased in 2 of the children. In the family study, results of an eye examination of 30 relatives were available. No other cases of high myopia or subnormal visual acuities were found. The father of the children, 1 of the paternal relatives, and 5 of the maternal relatives had low myopia. One maternal male cousin of the probands had a protanomalous colour vision defect. In the genealogical stydy, no relationship was found between the families of the father and the mother of the probands going back to the fifth generation. The heredity of this disorder is difficult to define. It could be autosomal dominant or recessive if the myopia only are taken into consideration. If the high myopias and cone dysfunction are considered to be parts of the same syndrome, the heredity could be x‐chromosomal recessive or autosomal recessiv

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02705.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.Full‐field electroretinograms were recorded from four different families with dominant retinitis pigmentosa. Two different types of the disease were recognizable and consistent within each pedigree, one with normal cone b‐wave implicit times (one pedigree) and the other with prolonged cone b‐wave implicit times (three pedigrees). The cone b‐wave amplitude was found to decrease with age, but the implicit time did not, suggesting that the amplitude is useful for monitoring the progression of the disease whereas the implicit time seems more suitable for distinguishing different types of the disease. The progression rate was analyzed in a large pedigree, spanning six generations, three of which were examined in detail. The recently described Pro23His gene was not detected in the f

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02706.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.Four patients with definite multiple sclerosis (MS) gave evidence of demyelinating plaques that produced a form of visual loss atypical of MS, i.e. homonymous quadrantanopsia (women, 22 and 30 years), and homonymous hemianopsia (men, 30 and 42 years). Cerebral magnetic resonance imaging (MRI) identified areas with increased signal intensity situated corresponding to the observed visual field defects. The results of visual evoked potentials (VEP) were in accordance with what should be expected from anatomical considerations.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02707.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.Important prognostic information may be gained from knowing the volume of intraocular tumors, such as choroidal melanomas. To measure such volume, we developed an ultrasonographic 3‐D scanning system, which operates by an axial, back and forth, half‐turn rotation of a commercial sector scanning transducer, applied directly onto a closed eyelid. Control of movement, data acquisition, and image analysis are accomplished by means of a microcomputer and application‐specific software. The elapsed time for scanning and digitizing 11 cross‐sectional images across a human eyeball, is 4 sec. Outlines of specific structures are traced manually. The system was tested through repeated, in vitro measurements of known volumes of meat; the mean variation coefficient of these measurements was 2.8%. While accurate estimates were obtained on volumes between 0.01–0.25 ml, these are linearly dependent on gain setting. A patient with a choroidal melanoma was scanned repetitively. The procedures of scanning and tracing contributed about equally to the total variance. This method of scanning allows repeatable, reliable, and easily generated measurements of a tumor's volume and, thus, has great potential for use in the diagnosis and treatment of malignant, intraocul

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02708.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.We measured blue‐green autofluorescence (AF, 495 nm/520 nm) of the lens in 43 random eyes of 43 healthy volunteers aged 6–86 years, five in each decade, using an instrument designed by one of us (HN). The instrument generates an autofluorescence profile, which consists of anterior and posterior juxtacortical peaks and a central plateau. The height of the anterior peak was taken as a maximum autofluorescence value and the square root of the ratio between the posterior and the anterior peak was used as a lens transmission index. The coefficient of variation for the measurement technique was 3.9% for maximum autofluorescence and 2.9% for lens transmission index. Both the maximum autofluorescence and the transmission index were highly correlated with age. Statistically over 90% of the variation in maximum autofluorescence values and almost 70% of the variation in transmission could be attributed to

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02709.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.In an unpaired study, in vivo measurements of pH in vitreous were performed on normal pig eyes and pig eyes treated with retinal xenon photocoagulation. In one group (n = 7) the mean vitreal pH was 7.29 at a mean arterial pH of 7.41. In the other group (n = 8) two to three weeks after retinal xenon photocoagulation, a significant increase in mean vitreal pH of 0.06 to 7.35 (P<0.01) was observed at a similar arterial pH. Induced hypercapnia resulted in a decrease in pH vitr. and induced hypocapnia in an increase, with similar changes in pH art. The respiratory pH changes were similar in the two groups. These findings allow one to assume that, as a result of retinal photocoagulation, a change in the retinal metabolism is induced, either by a change in the relationship between aerobic and anaerobic metabolism or as a result of a general reduction of the metabolic activity.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02710.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.We present our experience (at the King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia) with the management of the trachomatous eyelid disease. Four major eyelid complications: cicatricial entropion, eyelid retraction, secondary blepharospasm and brow ptosis, are described and their management outlined. Nine hundred sixty patients with cicatricial entropion are presented with thorough discussion of the surgical procedures and results. The surgical management of eyelid retraction, blepharospasm and brow ptosis is geared to provide the ophthalmologist with a complete overview of the disease pattern.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02711.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract.We recorded visually evoked cortical potentials to pattern stimuli (PVECPs) in 22 patients who received a posterior chamber intraocular lens implant. The mean latency of the P100 obtained from patients was not significantly different from that of age‐matched normal phakic subjects. Furthermore, we found that both groups showed a similar increased delay of the P100 latency with age. The results of this study indicated that the senile opacity of the crystalline lens does not contribute to changes of PVECPs with age. These alterations may be due to senile changes of the neural pathwa

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1991.tb02712.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY