ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08524.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.An inexpensive, disposable soft contact lens for extended wear (DanaLens) has been developed. The lens is polymerized moulded in the wet state from hydroxyethyl methylacrylate and hydroxyethyl acrylate. Twenty‐two pairs of the lens have in an open study been worn permanently from 1 to 43 days. light microscopical and scanning electron microscopical examinations of the used lenses showed: superficial deposits on the front surfaces of the lenses of a mucous‐like, easily removable material. Neither bacteria nor fungi were demonstra

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08525.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.The effect of sustained‐release artificial tear inserts on symptoms and signs of reduced tear production in keratoconjunctivitis sicca (KCS) was evaluated in an open clinical trial including 30 patients. A significant relief of sicca symptoms and a decrease in keratoconjunctival staining were seen in 10 patients fulfilling the study, whereas no significant effect on Schirmer test and tear break‐up‐time could be detected, neither in patients with pure KCS nor with KCS as a manifestation of Sjögren's syndrome. Twenty patients (67%) withdrew due to adverse effects, which were reported in total 80% of the patients. Absence of measurable tear secretion predicted treatment failure. Due to the frequent side effects, the artificial tear inserts cannot be recommended as a first line treatment in KCS pa

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08526.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.In a group of 66 daily hydrogel contact lens wearers, all lenses were cleaned and disinfected daily using a regular daily cleaner and a 3% hydrogen peroxide system. In addition, one of the lenses for each subject was subjected to weekly enzymatic cleaning with a multi‐enzyme pancreatin preparation. After 6 months there were highly significant differences (P<0.001) between the lenses, the enzymatically cleaned ones showing less deposits and longer break‐up time (BUT) on the lens. Also, comfort was significantly (P<0.05) better for these latter lenses. No adverse reactions that could be attributed with certainty to the preparations used were observed. The effectiveness of the pancreatin preparation employed in this study is of interest, since it has been demonstrated that enzymatic removal of deposits from hydrogel lenses reduces complications such as acute red eye reaction, contact lens‐induced papillary conjunctivitis, and presumably also corneal ulceration because of decreased bacterial adherence to the l

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08527.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.This study examines the microscopical appearance, location, distribution, subdivision and density of T‐lymphocytes in the human lacrimal gland. Fourteen glands, 7 from either sex, were removed and frozen shortly after the donors' death, and processed for immunoperoxidase staining, utilizing a biotinavidin system and one of the following monoclonal antibodies: Anti‐Leu‐1 and ‐Leu‐4, which recognize T‐lymphocytes, anti‐Leu‐2a, which binds to suppressor/cytotoxic T‐cells, and anti‐Leu‐3a+3b, which recognizes helper/inducer cells. The T‐lymphocytes in the human lacrimal gland were small to medium sized, mainly located in the interacinar tissue, often adjacent to an acinus or close to a collecting duct. The median number of each T‐cell subset per defined field (0.086 mm2) at x 500 magnification was as follows: Males: Leu‐1: 3.1, Leu‐2a: 4.9, Leu‐3a + 3b: 2.8, Leu‐4: 4.5. Females: Leu‐1: 4.3, Leu‐2a: 5.0, Leu‐3a + 3b: 3.7 and Leu‐4: 5.8. The sex difference was not statistically significant. The helper/suppressor cell ratio in the human lacrimal glan

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08528.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.We tested the effects of pre‐treatment with dexamethasone on topically induced ocular anaphylaxis in the rat. Rats were immunized with dinitrophenylated Ascaris suum extract and challenged with di‐DNP‐lysine. Dexamethasone was administered topically once (24, 6, or 1 h before challenge) or three times (6, 4, and 2 h before challenge). A single pre‐treatment given at 24 or 6 h had no significant effect. A single pre‐treatment 1 h before challenge reduced the extent of edema assessed histologically but not clinically, and had no significant effect on the eosinophil count in conjunctival tissue examined 6 h after challenge. Eyes pre‐treated with dexamethasone 6, 4, and 2 h before challenge showed a significant reduction in conjunctival edema assessed histologically and clinically 1 h after challenge. In addition, 6 h after challenge the number of eosinophils was significantly reduced. We conclude that repeated pre‐treatment with dexamethasone can suppress both the immediate phase and the cellular late phase of topically induced ocula

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08529.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.A serous retinal detachment and choroidal hemorrhagic infiltration developed in a 17‐year‐old girl with acute lymphoblastic leukemia one year after cessation of therapy without concurrent bone marrow (BM) or central nervous system relapse. A choroidal biopsy through a sclerotomy with simultaneous release of subretinal fluid revealed no malignant cells. Accordingly, she was treated with prednisone, topical corticosteroid and atropine with normalisation of vision and clinical findings. Five months later the retinal detachment and choroidal infiltration recurred. In order to re‐attach the retina once more and obtain a representative choroidal biopsy, a pars plana vitrectomy followed by a retinotomy with removal of subretinal tissue was done revealing leukemic infiltration of the choroid. Simultaneously a BM relapse was diag

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08530.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.The response of single detergent treated bovine retinal pigment epithelial cells in culture to ATP was measured with an image analyser. The most pronounced contraction was produced by 1.0 mM ATP with most change taking place in the first 10 min. At 1 h the area had decreased by about 33%, perimeter 22% and maximum length 25%. By way of comparison rabbit skin fibroblasts had a decreased area of approximately 40%, perimeter 25% and maximum length 22%. Bovine aortic smooth muscle cells on the other hand decreased in area by 55%, perimeter 40% and maximum length 36%. It is hoped that this assay may be used to evaluate drugs which could counteract contractile events in proliferative vitreoretinopathy.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08531.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.Corneal sensation was found to be decreased in eyes affected by acute angle closure glaucoma. In those patients with a short history (less than four days) the difference in sensation between the two eyes was only detectable using the Cochet‐Bonnet aesthesiometer and not by using cotton wool. Patients with a longer history had a more marked decrease in corneal sensation that was detectable by both methods. Corneal sensation in both groups tended to recover partially on normalization of the intraocular pressur

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08532.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.We studied the correlation between pre‐operative visual evoked potentials (VEPs) and postoperative visual acuities in patients with unilateral opaque media. The fellow eye was used as the control. The filtering effect due to opaque media could be assessed on the basis of the difference of the electroretinogram (ERG) threshold in the two eyes. ‘Modified VEPs’ were then calculated by eliminating the assessed filtering effects, which improved our ability to detect the potential for visual recovery. In the normal eye, the stimulus threshold for VEP is lower than that for ERG by 2 or 3 log units. Therefore should a higher stimulus threshold be found for VEP than ERG, severe optic nerve damage is highly probable in eyes with media opa

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1988.tb08533.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY