摘要:

In the family presented here, three out of seven siblings are affected, the onset of symptoms having occurred between 53 and 59 years of age. The family relationship was at first unknown. The parents are believed to have been eye healthy. Two of the cases are bilaterally involved and were investigated for suspected brain tumor. The neuroradiological examinations were negative. The visual symptoms, i.e. loss of visual acuity, visual field defects and blurring of the optic discs were in agreement with a diagnosis of ischemic optic neuropathy. In the latest case discovered, the affliction is thus far unilateral, and vascular changes in the retina corresponding to the visual field defect could be established by fundus photography and fluorescein angiography.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01094.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

A total of 545 men and 521 women of 50 years and older were examined for senile exfoliation without discernible glaucoma. Here, as elsewhere, exfoliation mainly occurs after the age of 60. In male patients exfoliation without glaucoma was found to be more frequent than in women (2.9%:1.7%). In the material 214 patients with open‐angle glaucoma were examined, of whom 147 were men (average 76 years) and 67 women (average 77 years). There were 84 men (57%) and 31 women (46%) with senile exfoliation.When looking for the causes or effects of senile exfoliation in glaucoma afflicted eyes, I am led to believe that in most cases it is primarily caused by glaucoma simplex, the exfoliation being the result of a long‐standing increase of tension with ensuing degeneration. More specifically, that in the ciliary and iris epithelial layers, mucopolysaccharide or other unknown substances are developed and occur as exfoliation materials in the various tissues of the

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01095.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Corneal sensitivity was measured prior to inserting hydrophilic lenses for 8 hours, just after removal, and again 15 min and 1 hour later. It was found that the sensitivity was not significantly different immediately after 8 hours of wear as compared to its initial value in the morning. However, after the lens had been removed for 1 hour, corneal sensitivity had diminished to a significant level indicating that soft lenses affected the sensitivity. This is understandable because corneal sensitivity normally increases throughout the day. It is felt that the reduction of corneal sensitivity induced by soft lenses may be due to some corneal oedema which might develop because the lenses hinder the evaporation of tears.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01096.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In a family of 84 members macular lesions were observed in 16 out of 75 examined individuals. The typical egg yolk lesion was seen in three cases while the remaining bore evidence of the polymorphous nature of the disease. Electro‐oculography (EOG) was performed on 11 affected individuals. EOG showed pathological changes in 10 of these. In one case the changes were localized to an eye which ophthalmoscopy had shown to be normal. EOG was performed on a further nine members of the family in whom ophthalmoscopy was normal. The values were subnormal in four of these. The significance of EOG in cases of macular degeneration is accentuated. Fluorescein angiography in colour was performed on two individuals. Hepatolenticular degeneration (Wilson's disease) had previously been diagnosed in members of one branch of this family. A possible connection between Best's and Wilson's diseases is advocated in the discussio

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01097.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The effects of a long‐term fall in intraocular pressure on the fluorescein angiographic findings of the disc and the peripapillary area were studied in 50 eyes with chronic open‐angle glaucoma by comparing angiograms taken before and 1 to 6 months after a glaucoma operation. After a remarkable fall (20 mmHg or more) in the intraocular pressure level, obvious narrowing was seen in the main retinal vessels. Filling defects of the peripapillary choroid or disc fluorescence were not clearly influenced by a decreased intraocular pressure level, thus indicating the presence of permanent anatomic changes in the peripapillary choroidal vasculature. Fluorescein angiography with the technique used cannot, therefore, be regarded as a suitable method for evaluating the safe pressure level in individual e

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01098.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In 71 cases of primary open‐angle glaucoma and in 29 cases of angle‐closure glaucoma a sinus trabeculoectomy was performed and the biopsy specimens were studied by light microscopy. A control group included 100 cadaver eyes.The anterior position of Schlemm's canal prevailed in cases of open‐angle glaucoma (82%) and the posterior position of the canal was more common in cases of angle‐closure glaucoma (57%).In glaucomatous eyes, Schlemm's canal was narrowed and in some cases obliterated. In eyes with open‐angle glaucoma the mean diameter of scleral spur was 21.6 ± 4.22 microns as compared to 85.2 ± 2.76 microns in normal eyes and 70.5 ± 9.40 microns in eyes with angle‐closure glaucoma.In 100 eyes with open‐angle glaucoma and in 112 normal eyes the position of Schlemm's canal was estimated by gonioscopy. The anterior position of Schlemm's canal was found in 67% of all the cases with open‐angle glaucoma and in only

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01099.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01100.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Horseradish peroxidase has been used in the cornea as a histochemical tracer for both light and electron microscopy. When the rabbit corneae, as little damaged as possible, were mounted between two lucite chambers containing a nutrient solution, and exposed to this enzyme on the epithelial side, no peroxidase reaction products were detected below the epithelial surface. When the endothelial side had been exposed for one hour or more, the enzyme had moved across the endothelium, the Descemet's membrane, the stroma, and up between the epithelial cells to thezonulae occludentesbetween the cells of the most superficial layer, adjacent to the tear film.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01101.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Experimental uveitis has been produced in two groups of albino rabbits by a single intravitreal injection of antigen. The animals in group I were immunized by injection of 10 mg of human serum albumin, whereas those belonging to group II received 50 mg of the same antigen. To study the blood‐aqueous barrier to proteins in the ciliary body of these eyes, horseradish peroxidase has been used as a cytochemical tracer by electron microscopy. The tracer was injected intravenously at different time intervals (1–30 min) before enucleation.In group I, in regions of inflammatory cell infiltration in the ciliary processes, peroxidase reaction product was observed in the lateral intercellular spaces of the superficial epithelium, in the internal limiting membrane, and in the posterior chamber, as evidence of breakdown of the epithelial diffusion barrier. In areas showing moderate or no inflammatory cell infiltration, the diffusion barrier to peroxidase was found intact, although the epithelium displayed marked morphological alterations.In the more heavy inflamed eyes belonging to group II, necrosis of the ciliary epithelium and thrombosis of the ciliary vessels were promin

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01102.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Experimental uveitis has been produced in two groups of albino rabbits by a single intravitreal injection of antigen. The animals in group I were immunized by injection of 10 mg of human serum albumin, whereas those belonging to group II received 50 mg. To study the blood‐aqueous barrier to proteins in the iris vessels of these eyes, horseradish peroxidase has been used as a protein tracer by light and electron microscopy. The tracer was injected intravenously at different time intervals (1–30 min) before enucleation.In group I, no leakage of peroxidase from the iris vessels was demonstrated in any eyes except one. The diffusion of peroxidase was halted by the zonulae occludentes of the vascular endothelium, and there was no evidence of vesicular transport of peroxidase through the endothelial cells. In the more heavy inflamed eyes belonging to group II, a prominent inflammatory cell infiltration was found in the iris. In these eyes leakage of peroxidase through the interendothelial clefts of the iris vessels was demonstra

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1974.tb01103.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY