摘要:

A survey from the Eye Pathology Institute and the Ophthalmological Tumour Centre, Copenhagen, of the present position of diagnosis and treatment of some of the more important tumours and tumour‐like lesions of the eye and its adnex

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00414.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Distribution of intravenously injected horseradish peroxidase (HRP) in the ciliary body of newborn and young (2 weeks old) rabbits was studied with the electron microscope.The reaction product was localized in all animals in the lumen of the blood vessels, in the perivascular area, in the surrounding connective tissue stroma and also in the epithelial cell layers. The peroxidase penetrated through the intercellular junctions of the pigmented cells to the intercellular space between the apical membranes of the two epithelial cell layers. In young rabbits peroxidase penetrated between the apical intercellular clefts of the non‐pigmented cells in small quantities only, whereas in the newborn animals the clefts were filled with peroxidase. This reflects differences in the blood‐aqueous barrier mechanism between the two studied groups and is evidently due to developmental stages of the e

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00415.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The resemblance between tonometer readings on relatives and spouses was studied in a material derived from a population survey and consisting of 1042 unique individuals forming 365 nuclear families and 1333 pairs divided into groups with different sex‐composition and type of connection. Persons in whom glaucoma was suspected were excluded. The general level of resemblance in the present study was similar to that in previous studies. Differences between groups with different sex‐composition conformed to a pattern expected from environmental effects. The resemblance between husbands and their wives was highly significant and of the same order of magnitude as that in relatives sharing a common genetic background. We concluded that a common environment contributes materially to the resemblance between tonometer readings on relatives. The possibility of a cumulative environmental effect was suggested by an increase in resemblance with

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00416.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Five cases of a rare type of malignant melanoma of the choroid with a typical clinical and histopathological picture are reported. This tumour is characterized by its location near the optic disk, its early growth through the retina, its structure with bloodless and blood‐filled cavernous spaces, and its manifestation by a massive haemorrhage into the vitreous. “Historical” cases are mentioned, showing that this rare tumour, occurring in about 1:250 of malignant melanomas of the choroid, has a Scandinavian tradition. The clinical and histopathological details are disc

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00417.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An epithelioma was removed from the iris and ciliary body of a six‐year‐old girl by a partial irido‐cyclectomy. Three months later recurrence of the tumour was seen in the equatorial zone of the fundus.Three weeks after application of transscleral cryotherapy around the neoplasm, a chorio‐retinal resection of the tumour area in the fundus was performed.The postoperative healing was satisfactory. Re‐examination 16 months later revealed a healthy eye.The results indicate that a circumscribed tumour can successfully be resected from t

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00418.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Multiple linear regression‐analysis of variance was used to define relationships between final visual acuity and several parameters in 31 patients with reattached primary rhegmatogenous retinal detachments. Older patient age, preoperative macular detachment, clinically visible macular lesions, greater detachment duration and extent, and higher subretinal fluid butyrylcholinesterase activity were all inversely related to final acuity. The relationship of each parameter to final acuity, in conjunction with and apart from all the other parameters, was defined. Collectively the parameters accounted for 85% of the variation about the mean of the clinically observed finally acuities. The parameters could be weighted to give a generally, reasonably accurate prediction of final acuity at the time of surgery. The findings are consistent with a pathophysiological sequence involving alterations in the choroidal circulation and the blood‐ocular barrier of the posterior segm

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00419.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The adrenergic innervation of the rat cornea was investigated by using the formaldehyde induced fluorescence (FIF) technique. The fluorescent nerves were observed mainly in the corneal stroma. Either cervical sympathectomy or pre‐treatment with reserpine completely abolished the fluorescence of the adrenergic nerves of the cornea. After a stereotactic coagulation of the ophthalmic division of the trigeminal nerve, no adrenergic fibres were visible in the cornea and the number of the fluorescent iridic nerves was also reduced to a marked extent. On the other hand, ciliary ganglionectomy seemed to have no effect on the adrenergic fibres of the cornea.When the rats had been pre‐treated with a monoamine oxidase inhibitor, nialamide, and noradrenaline, not only was there an increase in the intensity of the specific fluorescence, but also in the number of adrenergic nerves in the cornea.The epithelium was also shown to contain adrenergic nerves by administering high doses of nialamide combined with noradrenaline, both intravenously as well as topically on the cornea, under the protection of propranolol.It may be concluded that the rat cornea receives its adrenergic innervation along the posterior ciliary nerves. The short ciliary nerves do not appear to carry sympathetic nerves to the cor

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00420.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The thiocholine method for the demonstration of AChE‐containing fibres and the formaldehyde‐induced fluorescence technique for the visualization of adrenergic fibres were employed to study the innervation of the albino rat iris. The following denervations were performed in order to verify the origins of different nerve types: (1) extirpation of the ciliary ganglion, (2) extirpation of the superior cervical ganglion, (3) stereotactic coagulation of the ophthalmic division of the trigeminal nerve, and (4) all possible combinations of the above‐mentioned procedures.The denervations disclosed three main types of AChE‐containing nerves in the iris: (1) nerve fibres degenerating after ciliary ganglionectomy, (2) thick nerve bundles in the dilator region disappearing after trigeminal neurotomy, and (3) fibres remaining intact after any type of denervation. Cervical sympathectomy had no effect on AChE‐positive fibres.Under electron microscope AChE activity could be seen in the axolemma both in unmyelinated and in myelinated fibres.All fluorescent fibres vanished after ipsilateral cervical sympathectomy. Most of these fibres also disappeared after trigeminal neurotomy and the remaining fibres degenerated after subsequent ciliary ganglionectomy. On the basis of the present findings, the following conclusions can be drawn: (1) Most AChE‐containing fibres of the rat iris originate in the ciliary ganglion. (2) The majority of the myelinated sensory fibres of the rat iris also contain AChE. (3) There is no AChE in the adrenergic fibres of the rat iris. (4) All adrenergic fibres of the rat iris originate in the ipsilateral superior cervical ganglion, and (5) these fibres enter the iris along with both the long and short cil

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00421.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A case of lenticular chalcosis has been studied where the accidentally implanted brass fragment had been removed 2 years prior to extraction of the lens. Characteristic capsular inclusions were found which did not contain copper. The inclusions probably consisted of a lipoid material.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00422.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The present work is the first in a series of investigations on the effects of melanotropic drugs on retinal functions. The changes in the conventional ERG of the dark‐adapted, intact sheep eye were studied after iv administrations of quinine and chloroquine. Both drugs influenced the ERG in principally the same way. Small doses changed only thec‐wave amplitude which began to oscillate after a delay of about 1 hour. Larger doses had an immediate effect on both theb‐ andc‐waves. Theb‐wave amplitude dropped and thec‐wave showed an initial peak followed by oscillatory changes about 1 h later. These late changes were similar to those observed after administration of small doses of the drugs.The present results indicate that small doses of quinine and chloroquine have a delayed effect on the pigment epithelial cells, while larger doses exert a more immediate and general retinot

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1976.tb00423.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY