ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04777.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractPlasminogen activator activity in normal human tears was found to be 0.03 ± 0.02 IU/ml with casein plate, and 0.06 ± 0.04 IU/ml with a spectrophotometric method. Elevated levels of plasminogen activator activity (range 0.11‐2.05 IU/ml) were detected in the tear fluid of patients suffering from various corneal and conjunctival diseases including corneal ulcers, superficial keratitis, persistent epithelial defects, recurrent erosions, bullous keratopathy, contact lens associated erosions, alkali burns of the cornea, Mooren's ulcer, conjunctival pemphigoid, acute keratoconus, and corneal melanoma. Plasminogen activator activity, determined in the absence of fibrin in tear samples collected by capillary tubes at low flow rates, is considered to be the result of the presence of urokinase‐type plasminogen activator (uPA) deriving from the epithelial cells of the cornea and the conjunctiva. It is suggested that an increase in the level of uPA in tears plays an important role not only in ulceration (the formation and repair of epithelial and stromal defects), but also in the development and healing of a number of other inflammatory processes, infections, immunological processes, chemical burns, contact lens associated lesions; in the invasion of microorganisms and leukocytes, in edema formation, in neovascularization, and in the invasive growth of tumors in the cornea and the conjun

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04778.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractConjunctival vessels were examined with a slit‐lamp and the abnormalities were graded in 77 patients with sickle cell diseases, including 48 with sickle cell anaemia, 17 with sickle cell β°‐thalassaemia and 12 with HbS/HbC disease. The study demonstrated the occurrence of similar conjunctival vessel abnormalities for the three sickle cell diseases which are, however, more severe in HbS homozygotes than in the two other genotypes. An increase of the severity of the vascular abnormalities with the increase of patient age was also observed for HbS homozygotes. The data suggest that the conjunctival lesions accumulate and increase in severity in a similar fashion as other tissue damages observed in sickle cell dis

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04779.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractVaried manifestations of herpes simplex keratitis are postulated to be related to alterations or paucity of protective immune response to the virus. In this study lymphocyte subpopulations and marcophage inhibition factor (MIF) assay are investigated in herpes simplex keratitis. Active T‐lymphocytes are detected to be significantly low in active keratitis as compared to the healed stage (P<0.001) and normal control subjects (P<0.01). Active T‐cells are also lower in bilateral keratitis than in unilateral keratitis (P<0.01), and in stromal keratitis than in epithelial keratitis (P<0.05). Total E‐rosette‐forming cells and leucocyte migration inhibition factor (MIF) assay demonstrates significantly lower values in bilateral keratitis than in unilateral keratitis, and in stromal keratitis than in epithelial keratitis. On healing, total E‐RFC, active T‐cells and MIF values improved and are comparable to those found in normal subjects. Enumeration of absolute lymphocyte counts and EAC rosette‐forming cells (B‐lymphocyte cells) did not yield any differences. Our observations demonstrate paucity of cell‐mediated immune response in stromal keratitis. More marked deficiency is demonstrable in bilateral keratitis. Manifestations of herpes simplex keratitis and their healing is observed to be relatable to the level of cell mediate

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04780.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractWe describe a family tree from central Finland with 19 members of which 10 had typical granular corneal dystrophy (Bücklers 1938). This granular dystrophy seems to start from the subepithelial and anterior stromal region. In quite early ages the granules spread not only into the midstromal layers but also into the most posterior stroma between the stromal lamellae and Descemet's membrane. Corneal epithelial erosions were not noticed in this family. The central cornea was mostly affected and 2–3 mm of the corneal periphery was clear. No endothelial changes were found from the corneal midperiphery by specular microscopy. To date, two female patients have needed penetrating keratoplasty; one in her late thirties and the other in her early forties. Their corneal buttons were studied by electron microscopy and histochemically. Granular material was found between the stromal lamellae and also inside the stromal kerato‐cytes. Bowman's membrane was disrupted and degenerated in the areas where the deposits were situated in the subepithelial region. Recurrence of the disease was observed in the corneal transplants of the two operated patients 3 years postoperatively, starting again in the subepithelial region and mostly in central areas of the transplant. This disease entity seems to be different from the granular dystrophy also reported from Finland by Forsius et al. (1

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04781.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractIt was examined whether the healing promoting effect of Descemet's membrane on posterior corneal defects depends on heat labile molecules in the membrane. Localized thermal burns were produced by touching the posterior surface of rabbit corneas with a heated probe. This resulted in an endothelial defect, which was surrounded by a border of heat impaired, but living cells. The abnormal cells delayed the healing process by excerting contact inhibition on the surrounding undamaged endothelium. If the border of impaired cells was avoided by placing the 2 mm heat burn inside a 4 mm freeze erosion of the endothelium, the healing process was uninfluenced by the heat treatment. Conclusion: heat labile molecules in Descemet's membrane are not prerequisites for the healing promoting effect of the membrane on endothelial defects.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04782.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractThe Ontario Corneal Recipient Registry followed 299 recipients of 326 corneal transplants performed between October 1985 and October 1987. This report describes the joint effects of donor age and cause of death on subsequent graft survival in these procedures up to two years after surgery. Cox regression analysis established that grafts from donors dying of injury experienced half the risk of graft failure of those from donors dying of heart disease or other natural causes (P<0.05). Although donor age differed substantially between these causes of death, controlling for donor age did not alter the association. There were no statistically or clinically significant differences in graft survival associated with either donor age or recipient age. These results suggest that the health of the donor and the circumstances surrounding death may influence the quality of corneal tissue, and deserve more attention and detailed study.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04783.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractIn order to evaluate the tissue response to metal retinal tacks experiments were carried out on 4 monkey eyes and compared to those on 4 rabbits. Nonmagnetic retinal tacks (Grieshaber, Switzerland) and tacks made of 24 carat gold (our own brand) were inserted into the ocular fundus under microscopic control. The animals were kept for 3 months. In monkey eyes, histological examination disclosed a considerable fibrovascular proliferation around the retinal tack canal, including an inflammatory response, formation of collagenous tissue and glial proliferation. There was a local intra‐retinal and epi‐retinal neovascularization. In the rabbit retina, only a slight inflammation and thin collagenous tissue developed. Thus the tissue response was much more severe in the primate eye than in the avascular rabbit ret

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04784.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractA retrospective investigation of aphakic retinal detachments following intracapsular cataract extraction during a 12‐year period was performed. A total of 8350 eyes had intracapsular cataract extraction in the study period and 118 eyes developed aphakic retinal detachment. The occurrence of retinal detachment is related to age, sex, intraoperative complications, myopia, hyperopia, and pseudophakia. Age and myopia were significantly associated with aphakic retinal detachment. Previous aphakic retinal detachment in the one eye was a strong predictor for the other ey

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04785.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

AbstractMass health screenings for the elderly have been undertaken in Kuopio since 1983. Three different age groups, 65, 70 and 75 years old are called for examination so that each group is examined at 5‐year intervals. In 1989 an ophthalmologic examination was included in the protocol for those born in 1914 and 1924. A total number of 1133 persons were recruited, 833 (73.5%) of which actually participated in the study. Cataract was found to be the most frequent visual handicapper. Of participants with visual acuity<0.3 at least in one eye, cataract was observed in 41.7% of the younger and in 91.1% of the older group. Age‐dependent macular degeneration and glaucoma were less frequent than cataract. Visual acuity of less than 0.3 in the better eye was observed in 5.5% of the older gr

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1990.tb04786.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY