摘要:

Three eyes with senile detachment of the retinal pigment epithelium were complicated by tearing of the detached pigment epithelium with subsequent wrinkling or folding up of the pigment epithelium under the fovea. In all cases this only recently recognised complication of senile pigment epithelial detachment was documented before and after tearing by fluorescein angiography. In one eye pigment epithelial rupture was followed by rapid ingrowth of subretinal neovascularisation, and in one eye neovascularisation was suspected, although no definite new vessels could be observed.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01388.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Gyrate atrophy of the retina and choroid is an autosomal recessive disease characterized by progressive retinal degeneration and ornithine aminotransferase deficiency. We report here the new histological findings and ultrastructural changes in 3 iridectomy specimens from 2 Finnish patients with gyrate atrophy. The iridectomy specimens were removed during routine cataract extraction and studied with a transmission electron microscope. The dilator muscle showed atrophy, abnormall mitochondria, and tubular aggregate type structures similar to those found in skeletal muscle. Degenerative changes such as extracted cellular matrix, dropout of cellular organelles, and dilated intercellular spaces were observed in the pigmented posterior epithelium and the anterior iris epithelium.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01389.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The effect of an intravenous injection of sodium iodate on the retinal pigment epithelium immediately surrounding the optic nerve head has been investigated using horseradish peroxidase as a morphological tracer. A sodium iodate injection leads to a necrotic reaction of practically the complete retinal pigment epithelium. The juxtapapillary pigment epithelium, however, showed only attenuation and depigmentation without any necrotic reaction 4 and 12 days after the injection. Twenty‐six days following the injection the epithelium had almost normalized. The result of this study thus demonstrates a noteworthy resistance of the juxtapapillary retinal pigment epithelium against the sodium iodate effect. At no stage was there a clear indication of a breakdown of the permeability barrier constituted by the juxtapapillary retinal pigment epithelium. Horseradish peroxidase moved into the peripapillary sensory retina by lateral diffusion from the surrounding retina and diffused into the optic nerve head proper, confirming the presence of a diffusional pathway through the Kuhnt intermediary tissu

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01390.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A medium frequency flicker stimulus of 10 Hz is evaluated in routine clinical ERG recording in detecting cone disorders. Tested on a number of normal eyes and on eyes with confirmed or suspected retinal disease it appears to be very useful as a complement to the standard program with the Krakau‐Öhman apparatus. It yields an easily recordable and quantified respon

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01391.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Intrasplenic implantation of syngeneic islets normalized the hyperglycaemia of alloxan‐diabetic mice irrespective of whether the implantation was performed 2 weeks or 4 months after the induction of diabetes. Islet implantation soon after the onset of diabetes prevented the development of retinal capillary disease as evidenced by a normal ratio between endothelial cells and pericytes. The increase of the cell count ratio (endothelial cells/pericytes) induced by long‐term diabetes could not, however, be restored by islet implantation. The present results further underline the importance of optimal treatment for prevention of diabetic retinopa

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01392.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

In 17 patients treated with tamoxifen in a low dosage (30 mg daily) ophthalmological examination was performed. This revealed 2 cases with possible retinotoxic effect. A 64 year‐old woman treated with tamoxifen for 9 months for metastatic breast cancer developed retinopathy with transitory visual impairment. The retinopathy was morphological characterised by multiple yellowish‐white dots in the posterior pole, a parafoveal haemorrhage and accumulation of reticular pigment changes in the periphery of the retina. By retinal fluorescein angiography multiple non‐fluorescent dots and hyperfluorescent areas were seen in the posterior pole. The retinal lesions remained unchanged except for the haemorrhage after discontinuation of the tamoxifen treatment. In another patient some of these changes were also found. The retinotoxic effect of tamoxifen has been reported previously with tamoxifen in high dosage (≥ 180 mg daily, minimal total dosage of 90 g) used for long periods, but never from this drug in low dosage (30 mg daily, minimal total dose 8.1 g

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01393.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Eight patients with active toxoplasmic retinochoroiditis were treated with clindamycin and a triple sulphonamide combination for a period of up to 6 weeks. In addition systemic prednisone was administered when the optic nerve or the macula was involved (6 of the 8 cases). In all cases we observed clinical improvement within 2 weeks. Visual acuity improved in all cases. Side effects of the treatment were observed in 2 cases. The follow‐up period ranged from 8 to 22 month

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01394.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The authors test the hypothesis of systematic errors in photometric and/or densitometrc measurements performed by Fundus camera equipment. By means of 2 different methods (reflection and transmission) the non‐uniformity of light‐distribution on sample surfaces placed in front of the fundus camera is shown. The consequent point by point variability in retinal illumination can be defined as the ‘retinal shading problem’. This conclusion must be taken into account when equidensitometric measurements are carried out on eye fundus images with fundus camera, by photographic, cinematographic or TV tec

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01395.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

In 287 consecutively intracapsular cataract extracted eyes with a Federow intraocular lens implant (IOL) and 290 eyes with consecutively performed intracapsular cataract extractions (ICCE) the final visual outcome and complications were examined in a retrospective study. The average observation time was 31 months in the IOL group and 37 months in the ICCE group. Seventy‐five per cent in the IOL group and 77% in the ICCE group achieved a visual acuity ≥ 0.5. The main cause of a visual acuity<0.5 was maculopathy pre‐operatively recognized. A visual acuity<0.5 due to post‐operative complications occurred more frequently in the IOL group (28 eyes) compared with the ICCE group (13 eyes) ‐P<0.01. Twelve intraocular implants (4.3%) had to be removed. The most important cause was dislocation of the IOL (9 eyes). During our first 12 months of IOL implantation 8 dislocations occurred out of 56 implanted eyes (14.3%). The remaining 6 dislocations occurred among the last 231 IOL eyes (2.6%). It is concluded that complications are few, but often serious in intraocular lens implant surgery. Careful pre‐operative examination and surgical experience ar

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01396.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Polymethylmethacrylate intraocular lenses with polypropylene loops were incubated in fresh human serum to determine and quantitate the effect of these lenses on haemolytic levels of C1, C4, C2, C3 and C5 and levels of Factor B and C3c measured by radial immunodiffusion. We were unable to demonstrate any statistically significant differences in complement levels in serum after incubation for 1 h with and without an intraocular lens. After incubation of serum for 3 h with and without an intraocular lens, we were able to demonstrate a statistically significant reduction in C3 by haemolytic assay but not in C3c by radial immunodiffusion. There were no statistically significant differences at 3 h in C1, C4, C2, C5 and Factor B. The results of this study suggest that intraocular lenses do not have a substantial effect on complement levels.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1983.tb01397.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY