ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05775.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

As a part of more comprehensive examination of 180 patients with optic disc drusen, fundus photographs of 159 cases were evaluated. There were 70 patients whose optic discs were photographed two or more times during the years from 1967 to 1981. Four patients were selected to present the changes which can take place in optic discs with drusen and the alterations are demonstrated by autofluorescence pictures, stereophotographs, and electronic subtraction method.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05776.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The effect on intraocular pressure (IOP) of topical timolol was studied in 30 patients with arterial hypertension treated with oral alprenolol, metoprolol or timolol. No patient had any known eye disorder. Topical administration of timolol induced a significant reduction of IOP regardless if the patients had systemic β‐blockade or not. Treatment with topical timolol alone was equally effective in reducing IOP as combined topical and oral therapy. Patient compliance was checked with plasma concentrations of the different β‐blo

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05777.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Electron capture gas chromatography was used to determine plasma concentrations after various doses of acetazolamide. In 40 patients steady state plasma concentrations were determined for daily doses of 187.5, 375, 750, and 1000 mg. Mean plasma concentrations increased with increasing dosages but there were marked interindividual variations. Part of the interindividual variation was explained by a positive correlation between age and plasma concentration. In 10 patients with previously untreated glaucoma intraocular pressure (IOP) responses and plasma concentrations were determined for increasing doses of acetazolamide. Increasing IOP reductions were obtained up to a dose of 750 mg while a daily dose of 1000 mg acetazolamide had no further effect on IOP. The relationship between IOP reduction and plasma concentration showed great interindividual variations, from a pressure reduction of 11 mmHg at 6 μg/ml acetazolamide to a pressure reduction of 0 mmHg at 11 μg/ml. As a rule, the maximal effect on IOP was obtained at a plasma concentration between 5 and 10 μg/ml. In most patients a daily dose of 1000 mg resulted in plasma concentrations above 10 μg

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05778.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Salt tablets are habitually ingested by some people while doing physical exercise in hot climate, in order to prevent sodium depletion. The effect of supplementary salt on the intraocular pressure was investigated on 5 healthy acclimatized subjects who rode a bicycle ergometer at temperature of 35°C and relative humidity of 40%. A significant decrease of 1.0 mmHg in their mean intraocular pressure was detected when 10.2 gm NaCl was added daily to the normal diet. The pressure reduction was associated with changes of the body fluid balance

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05779.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The rabbit cornea endothelium has been studied with specular and scanning electron microscopy after exposure with a commercially available ultraviolet lamp. The animals were plased 50 cm from the source, and most experiments were run with a 20 min exposure time. In the specular microscope, the endothelium revealed numerous circumscript reflex‐free areas, which were observed from 4 days up to 8 months after the irradiation. A wide varity of changes were found in the scanning electron microscope. One day after the exposure the cells showed indistinct outlines, and they were bulging into the anterior chamber. In some regions the pattern was dominated by marked grooves preferentially along the cell demarcations, whereas other regions showed rough surfaced cells because of cytoplasmic projections and grainy deposits. At the 3 days stage there was a marked pleomorphy, and some cells were on their way to being rejected. After one week the cobblestone appearance of the endothelium was about to decline. Partly rejected cells were still common. In addition, distinct, ringshaped local impressions occurred imitating the previous described grooves. This phenomenon along with some single endothelial cells studded with microvilli were the abnormal findings 8 months after the damage. It is concluded that although ultraviolet radiation is largely absorbed in the cornea, the threshold dose for damage of the endothelium is not beyond those used for practical purpose. The endothelium was surprisingly resistent towards repeated radiation damag

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05780.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Reflex‐free areas of the cornea endothelium are demonstrated by specular microscopy after heavy bilateral photokeratitis. The changes are believed to be caused by UV‐radiat

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05781.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Variations in central corneal thickness during the first year of hard, hydro‐philic or silicone lens wear are reported. The mean corneal swelling after 1/2, 3 and 6 months was 4.7‐3.0% in the first 2 groups (P<0.001 ‐P= 0.005), but only 1.3‐0.8% in the latter group (P= 0.011 ‐ 0.050). These differences were statistically significant (P<0.001 ‐P= 0.046) and are ascribed to a higher oxygen tension under the silicone lenses. An over‐all reduction of corneal oedema was noted after 1/2 month (P= 0.025). One year after lens fitting a similar and not significant corneal swelling was found in the 3 lens groups. In addition to an initial ‘osmotic’ adaptation our results indicate that a further corneal adaptation to hard and hydrophilic lenses may take place between 6 and 12 months after lens fitting. Development of lens intolerance was not correlated to the degree of corneal oedema after 1/2 m

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05782.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The absorption of tear fluid into the Schirmer‐I‐filter paper was evaluated by serial measurements in 5 normal volunteers and in 32 patients with Sjogren's syndrome. The length of wetting was correlated to the weight of tear fluid absorbed in the paper strips. A linear relationship was demonstrated. We conclude that the Schirmer‐I‐test implies reproducible and fairly precise estimation of the tear flow even in cases of small lengths of wetting. The test is reliable, simple and useful for the diagnosis and follow‐up of dry eyes, especially in patients with Sjögren

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05783.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Sixteen specimens from 14 patients with typical conjunctival spheroid bodies were obtained by biopsy. Six biopsies were examined histochemically and 10 ultrastructurally. For comparison tissue from Pingueculae was processed simultaneously in 4 cases for light microscopy and in one for electron microscopy. The spheroid bodies were found to be strongly autofluorescent and of a proteinaceous nature, corresponding to the elastotic degeneration in Pingueculae. Ultrastructurally they were of various electron density, but when distinguishable the fine structure was granular with transition from surrounding collagen fibres. Based on reports from the literature and on our own investigations, it is concluded that condensations seen as spheroid bodies in both conjunctival and corneal tissue under solar/climatic influence are similar and have their origin in degenerated collagen.

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1982.tb05784.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY