摘要:

AbstractIn an unselected population sample of 505 adult Greenland Eskimos limbal chamber depth (LCD) was estimated according to van Herick et al. (1969), and axial chamber depth (ACD) was measured optically using Haag Streit pachymetry. For comparison LCD was estimated in 308 Danes above 40 years. A marked naso‐temporal asymmetry in LCD scoring was found indicating a shallower chamber at the temporal limbus. No corresponding gonioscopic asymmetry was observed. Significant age, sex, and ethnic variations were demonstrated, the lower levels of both parameters being found in elderly persons, women and Eskimos, respectively. Danes showed a lower level of LCD scores than reported in Americans. In detection of eyes showing shallow chambers in the Eskimo population (arbitrarily: ACD ≦ 2.0 mm) the van Herick slit‐lamp test at temporal limbus yielded a sensitivity of 91%, a specificity of 53% and predictive values of a positive and a negative test of 30% and 96%, respectively. At gonioscopy narrow angles were often found among eyes showing LCD ≤ 1/4 of corneal thickness, even when ACD was>2.0 mm (

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00674.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractNinety‐three patients, who during a mass screening for glaucoma in 1962‐63 attended a thorough ophthalmological examination, were re‐examined in 1980‐82. At the mass screening 42 patients had IOP ≧ 21 mmHg in at least 1 eye, but none of the 93 patients had glaucomatous optic disc excavations or visual field defects. At the re‐examination, 28 patients (30.1%) had developed manifest open angle glaucoma in at least 1 eye. This development was significantly correlated to the height of the IOP, both at the mass screening, during the period of observation and at the follow‐up study (P<0.05‐P<0.002). A reduced outflow facility measured at the mass screening was also significantly associated with the later development of manifest glaucomatous damage (P<0.05‐P<0.01). In addition, fibrillopathy (pseudoexfoliation), manifest glaucoma in the ‘fellow eye’ and a positive family history for glaucoma were found to be i

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00675.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe influence of timolol on the corneal epithelium and endothelium was studied in organ culture. The cell morphology was not influenced by drug concentrations ≦ 690 μg/ml. Cell death was observed at 6900 μg/ml. Endothelial cell proliferation after an experimental injury was slowed down at a drug concentration of 690 μg/ml. Injurious effects were not observed at the drug concentrations found in the aqueous humour by use of ophthalmic eye solution in eyes with a normal cornea. However, it may be indicated to use eye drops with reduced concentration of timolol in conditions facilitating the resorbtion of the

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00676.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe enzymatic activity of adenylate cyclase in homogenates and membrane‐rich fractions prepared from rabbit iris‐ciliary bodies and bovine trabecular meshwork was found to be inhibited by timolol. Treatment of iris‐ciliary body homogenates with Triton X‐305 resulted in abolition of the inhibitory effect of the drug on the activity of the enzyme. The stimulatory effect of salbutamol on the enzyme was also susceptible to blockade by timolol. It is suggested that the hypotensive action of timolol on intraocular pressure results from structural and functional changes induced on the plasma membranes of the iris‐ciliary body and trabecular meshwork by the thiadiazole group of the molecule, and, also, from the occupation of the adrenergic receptors of the iris‐ciliary body by the tert‐butylamino‐2‐hydroxypropoxy par

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00677.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractWe studied the corneal endothelial cells in 14 patients (6 men and 8 women, ranging in age from 15 to 70 years) with unilateral Fuchs' heterochromic cyclitis (FHC) by means of specular microscopy. The healthy fellow eyes of the patients served as control material. Two affected eyes had undergone an intracapsular cataract extraction before specular microscopy. In one patient, the cyclitic eye also had glaucoma. Changes of the endothelium characterized by intra‐and intercellular dark bodies, larger dark defects spanning several endothelial cells and bright irregular patchy areas crossing cell borders on the specular reflex were found in all eyes with FHC.Individual cell analysis did not reveal any significant differences in the endothelial cell density, cell area, coefficient of variation for cell area, cell perimeter, cell shape and in the number of endothelial cell apices between unoperated cyclitic and healthy fellow eyes. The mean cell density was 4.9% lower in the unoperated eyes with FHC than in the control eyes. A significant negative correlation was observed between the patients' age and the cell density both in the healthy and the cyclitic eyes. On the other hand, the correlation between follow‐up period and cell density was not statistically significant in the cyclitic eyes. Although FHC does not seem to accelerate significantly the age‐related cell density reduction, the magnitude of the cell loss found in the two operated eyes (45.5% and 49.8%) and in the eye with glaucoma (45.2%) may indicate altered tolerance against endothelial traumas in this di

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00678.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractLevels of serum fibrin degradation products were measured by the Staphylococcal clumping test in patients with acute idiopathic anterior uveitis and traumatic anterior uveitis. We found them to be significantly increased (P<0.001) in patients with acute idiopathic anterior uveitis (11.0 μg/ml). The extent of this increase in the serum levels of fibrin degradation products correlated well with increased severity of the disease. It showed return to normal levels (5.0 μg/ml) with the clinical improvement. It increased again with the re‐appearance of acute stage of the disease. We found no alteration in the levels of serum fibrin degradation products in patients with traumatic anterior uveitis. We hypothesise that uveal deposition of immune complexes causes secondary platelet damage and intravascular coagulation which results in uveal tissue damage through inflammat

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00679.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractMonozygotic twin sisters were afflicted by a chronic progressive neurological disease characterized by slurred speech, nystagmus and oculogyral spasms as well as further extrapyramidal and lower motor neuron abnormalities. At autopsy severe loss of nigral and craniospinal motor neurons was noted. In the nuclei of most nerve cell types of the central and peripheral nervous system, roundish inclusion bodies of 3 to 10 μm in diameter were found. Ocular pathology revealed the presence of identical inclusion bodies in the ganglion cells and ganglion cell loss in the posterior retina. Retinal astrocytosis and loss of myelinated axons of the optic nerve were interpreted as reactive features. No inclusions were found in the retinal pigment epithelium. Careful neuro‐ophthalmological studies of the first‐degree relatives revealed low b‐wave of the ERG with other slight aberrations. These were assumed to represent either a carrier or a subclinical state of this presumably inherited di

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00680.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractA micropolarographic system was used to measure the flux of oxygen crossing the tear‐epithelial interface of the human cornea just following stabilization of four lid closure conditions. In all, 215 oxygen flux measurements were made on the corneas of 6 young healthy subjects, including 2 reference conditions: the normal open eye and anterior surface oxygen deprivation. When compared with the temperatures associated with certain of those conditions, oxygen demands greater than those predicted by a previous Q10measurement were found. Proportional contributions of the non‐temperature factor are presented, and the nature of its components sugges

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00681.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractRabbit corneas were stored for 3, 7, 10 or 14 days in MK medium or K‐Sol. Corneas were thinner immediately following removal from K‐Sol than following removal from MK medium at all time periods studied. Following 3 days of storage, corneas stored in both solutions showed similar temperature reversal characteristics. Corneas stored for 7 and 10 days in MK medium also temperature reversed, whereas those stored in K‐Sol did not. Corneas stored for 14 days in both solutions swelled following mounting in the specular microscope. Endothelial cell morphology was similar following storage in MK medium and K‐Sol at all time periods studied. It is postulated that a persistant osmotic gradient is present across the endothelium following storage in K‐Sol. This osmotic gradient occurs because of retention of chondroitin sulphate in the corneal stroma thereby preventing early temperature

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00682.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractRetinoblastoma‐like cells grew in colonies on the bottom of tissue culture flasks. The population doubling time was 19 h. Tumour cells from cell cultures had a 39% plating efficiency, and fresh tumour cells from intraocular tumours had a 32% plating efficiency in colony forming assays. Inoculation of 1.5 times 104tumour cells in the vitreous of F‐344 rats resulted in a 100% tumour take and regularly growing tumours with a doubling time of 3 days. The tumour take‐rate was not changed in wholebody immunosuppressed animals. The tumour volume was assessed under a stereo microscope, and it was possible to divide the tumours into 4 groups according to the number of intraocular tumour cells. Tumour growth caused eye perforation in 89% of the inoculated eyes. Spontaneous tumour regression was not seen in non‐perforation groups. Immunosuppression with whole‐body irradiation and dense traumatic cataract had no significant effect on the growth. It is concluded that this animal retinoblastoma‐like tumour is suitable for quantitative therapy studies in vivo a

ISSN:1755-375X    

DOI:10.1111/j.1755-3768.1986.tb00683.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY