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11. |
Plasma Arginine Vasopressin Response to Hypertonic Saline Infusion in Alzheimer Disease |
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Alzheimer Disease and Associated Disorders,
Volume 9,
Issue 4,
1995,
Page 238-242
Elaine Peskind,
Marcella Pascualy,
Steven Edland,
Dane Wingerson,
Dorcas Dobie,
Murray Raskind,
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摘要:
Summary In this study, we tested the hypothesis that the plasma arginine vasopressin (AVP) response to osmotic stimulation induced by hypertonic saline infusion is blunted in the early and middle stages of Alzheimer disease (AD). Because animal data support stimulatory cholinergic mediation of AVP osmoregulation at a brain level, the AVP response in AD might provide clinically useful information about the status of brain cholinergic systems. Seventeen AD outpatients and eight normal older subjects underwent both a 90-min hypertonic saline infusion and a 90-min control (normal saline) infusion. Substantial increases in plasma osmolality during hypertonic saline infusion were accompanied by substantial and linear increases in plasma AVP in both groups. However, there were no significant differences in AVP responses between AD and normal older subjects. These results do not support the utility of plasma AVP response to hypertonic saline in the assessment of brain cholinergic status in AD.
ISSN:0893-0341
出版商:OVID
年代:1995
数据来源: OVID
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12. |
Orthostasis in Alzheimer DiseaseA Retrospective Analysis |
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Alzheimer Disease and Associated Disorders,
Volume 9,
Issue 4,
1995,
Page 243-246
Stanford Jhee,
John Sramek,
Thomas Wardle,
Neal Cutler,
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摘要:
Summary Vitiello et al. (1993) recently reported statistically significant decreases in systolic blood pressure upon standing in patients with Alzheimer disease (AD) (n = 60) as compared with healthy elderly controls (n = 20), which would suggest a possible autonomic dysfunction associated with AD. To investigate this issue, we conducted a retrospective analysis of blood pressures and heart rates of 31 patients 55–85 years of age (mean 69.6) who met National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer Disease and Related Disorders Association criteria for probable AD. The patients were selected from a pool of placebo-treated patients with AD in five inpatient phase 1 clinical trials. All patients met rigorous entrance criteria and thus were in excellent physical health except for AD. Blood pressure and pulse were assessed after 3–5 min of lying down and after 1–3 min of standing. Systolic and diastolic blood pressures showed decreases upon standing of 12 mm Hg (8.6%) and 6 mm Hg (8.2%), respectively, on day 1 and decreases of 10 mm Hg (7.6%) and 4 mm Hg (5.7%), respectively, on day 7 of hospitalization (p < 0.05). Pulse rates increased upon standing by 17% and 13% on days 1 and 7, respectively (p < 0.05). Our data support the finding of Vitiello et al. of significant postural decreases in systolic blood pressure in patients with AD. Well-controlled, prospective studies of orthostasis in AD and healthy elderly subjects should be conducted to determine its prevalence in both populations and to determine whether the orthostatic changes seen in AD differ from those in normal aging.
ISSN:0893-0341
出版商:OVID
年代:1995
数据来源: OVID
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13. |
The Mental Status Examination in Neurology |
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Alzheimer Disease and Associated Disorders,
Volume 9,
Issue 4,
1995,
Page 247-248
R. Strub,
F. Black,
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ISSN:0893-0341
出版商:OVID
年代:1995
数据来源: OVID
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14. |
Alzheimer Disease and Associated Disorders Vol. 9, 1995 |
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Alzheimer Disease and Associated Disorders,
Volume 9,
Issue 4,
1995,
Page 249-250
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PDF (82KB)
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ISSN:0893-0341
出版商:OVID
年代:1995
数据来源: OVID
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15. |
Alzheimer Disease and Associated Disorders Vol. 9, 1995 |
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Alzheimer Disease and Associated Disorders,
Volume 9,
Issue 4,
1995,
Page 251-251
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PDF (122KB)
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ISSN:0893-0341
出版商:OVID
年代:1995
数据来源: OVID
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