摘要:

SummaryAn antibody raised against isolated paired helical filaments (PHF) was used to identify tangle-bearing (PHF+) neurons in autopsy brain tissue from six Alzheimer disease (AD) patients and six age-matched controls (AMC). A comparison of the levels of polyadenylated messenger RNA [poly(A)+mRNA] in PHF+and PHF∼ neurons of similar cross-sectional area in temporal and parietal lobe and cerebellum from four AD and four AMC brains was made by analysis of in situ hybridization of [3H] polyuridylate [poly(U)] to intracellular poly(A)+mRNA. In PHF+neurons, the level of poly(A)+mRNA was approximately two-thirds that in similar-sized PHF-neurons in either AD or AMC. The level of poly(A)+mRNA in PHF-neurons in regions of the brain that have more of the histopathologically defined effects in AD was similar to that in regions with less effects.

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

SummarySerum and cerebrospinal fluid (CSF) of 56 patients with dementia of the Alzheimer type (DAT) and 33 healthy controls were examined in order to investigate intra-blood-brain-barrier (intra-BBB) synthesis of immunoglobulins. Intra-BBB immunoglobulin G (IgG) synthesis was defined as an elevated IgG index (>0.7) and/or presence of oligoclonal IgG in CSF but not in serum on isoelectric focusing, and intra-BBB immunoglobulin M (IgM) synthesis as an elevated IgM index (>0.06). In total, 10 (18%) DAT patients displayed an intra-BBB immunoglobulin synthesis—five (9%) an IgG and five (9%) an IgM synthesis—but none among the controls. Also, the DAT patient group showed higher mean IgG and IgM indexes than the control group. These findings support the hypothesis that immunological mechanisms may play a role in the etiology and/or pathogenesis of Alzheimer disease, at least in a subgroup of patients.

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

SummaryAnalyses of brain tissue in a recently identified group of elderly demented patients suggest a neurochemical basis for some of the clinical features. Senile dementia of the Lewy body type (SDLT) can be distinguished from classical Alzheimer disease (AD) clinically by its acute presentation with confusion frequently accompanied by visual hallucinations, and neuropathologically by the presence of Lewy bodies and senile plaques (but not generally neurofibrillary tangles) in the cerebral cortex. Reductions in the cortical cholinergic enzyme choline acetyltransferase were more pronounced in individuals with (80%) compared to those without (50%) hallucinations and correlated strongly with mental test scores in the group as a whole. In the caudate nucleus, dopamine levels were related to the number of neurons in the substantia nigra, there being a 40–60% loss of both in SDLT—probably accounting for mild extrapyramidal features in some of these cases—compared with an 80% loss in Parkinson disease and no change in AD. The cholinergic correlates of mental impairment in SDLT together with the relative absence of cortical neurofibrillary tangles and evidence for postsynaptic cholinergic receptor compensation raise the question of whether this type of dementia may be more amenable to cholinotherapy than classical AD.

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

SummaryTwo measures of profile similarity have been derived that offer complementary information about the classification of patients with diagnoses of probable dementia of the Alzheimer type (DAT). These measures were obtained for 31 probable DAT patients and 31 age- and education-matched controls using a set of six newly constructed cognitive scales designed to provide reliable measurement in both patient and control groups. A measure assessing similarity to the average performance of the controls provided perfect separation of the patient and control groups. A measure assessing similarity to the average performance of the probable DAT patients identified up to four atypical cases of probable DAT. One of these four cases has come to autopsy and was found to have Pick disease. The cognitive profiles of this Pick patient and an autopsy-confirmed DAT patient are compared to illustrate the potential advantages of using DAT patients as the reference group for profile analysis.

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1990

数据来源: OVID