ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Assessment and treatment of behavior problems in patients with Alzheimer disease and related disorders is a seriously neglected area of study. Despite the fact that such problems are integral to the disorder, little is known about effective management. This article summarizes the current thinking on five areas of prime importance to patients, care providers, and health care professionals: agitation, assault/aggression, screaming, wandering, and depression/apathy/withdrawal. Methodological guidelines for studying these disorders are provided. Emphasis is on recognizing that behavior problems are important areas of study in their own right as well as in conjunction with studies of cognition.

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

The Alzheimer Disease Assessment Scale (ADAS) was administered to 61 patients with dementia of the Alzheimer type (DAT) and 52 elderly controls. The DAT group was subdivided into different severity levels of dementia based on scores from the Mini-Mental State Exam: very mild (≥24), mild (20 to 23), moderate (10 to 19), and severe (0 to 9). The mean scores on the ADAS Cognitive subscale for the four levels of dementia (very mild = 23.1 ± 7.7, mild = 22.9 ± 8.9, moderate = 38.6 ± 9.8, severe = 54.8 ± 7.6) were statistically different from one another (p< 0.0001, except very mild vs. mild) and were significantly worse than the scores of the elderly control group (5.5 ± 2.7,p< 0.0001, ANOVA). Furthermore, the ADAS Cognitive subscale was highly effective in discriminating individual Alzheimer patients from elderly controls. The ADAS Cognitive score correctly classified 100% of the very mild group, 91% of the entire mild group, and 100% of the moderate and severe groups when a cutoff score of 2 SDs above the control group mean was used. Age and education had only minimal effects on the ADAS Cognitive score. The ADAS is a valuable screening test that only takes 30 min to administer and has utility in both early detection and staging of DAT.

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Patients with Alzheimer disease (AD) suffer mental deterioration associated with neurofibrillary tangle and senile plaque formation in the brain. Here we have determined the effects of brain extracts from normal and from AD patients on neuronal process formation by a pheochromocytoma (PC-12) and a neuroblastoma x glioma hybrid cell line (NG108–15). PC12 cells show a dose-related stimulation of branching of neuronal processes by AD brain extracts with cells cultured on a laminin substrate. The neurotrophic effects of extracts of AD brains may be related to the abnormal sprouting and neurofibrillary tangle formation observed in the brain in this disorder.

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Primary degenerative dementia (PDD) and multiinfarct dementia (MID) are the two most common categories of cognitive decline in old age. The definitions of these two clinical entities are currently based on clinical evaluation and on the exclusion of other underlying causes, and still lack a consensus. The DSM-III-R criteria are widely used for the diagnosis of dementia. However, their role in the differentiation between PDD and MID has not been thoroughly examined. A consecutive series of 98 demented patients who met the DSM-III-R criteria for dementia were admitted to a clinical study. Upon evaluating their type of dementia according to these criteria, 53 patients could not be diagnosed either as having PDD or MID. The DSM-III-R criteria for these two types of dementia are critically reviewed. Proposed modifications, aimed at refining their differential diagnostic role, are presented, enabling better allocation of demented patients into PDD, MID, or intermediate groups.

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1992

数据来源: OVID