摘要:

Alzheimer disease (AD) is the most common dementing illness in the elderly, but there is equivocal evidence regarding the frequency of other disorders such as Lewy body disease (LBD), vascular dementia (VaD), frontotemporal dementia (FTD), and hippocampal sclerosis (HS). This ambiguity may be related to factors such as the age and gender of subjects with dementia. Therefore, the objective of this study was to calculate the relative frequencies of AD, LBD, VaD, FTD, and HS among 382 subjects with dementia from the State of Florida Brain Bank and to study the effect of age and gender on these frequencies. AD was the most frequent pathologic finding (77%), followed by LBD (26%), VaD (18%), HS (13%), and FTD (5%). Mixed pathology was common: Concomitant AD was present in 66% of LBD patients, 77% of VaD patients, and 66% of HS patients. The relative frequency of VaD increased with age, whereas the relative frequencies of FTD and LBD declined with age. Males were overrepresented among those with LBD, whereas females were overrepresented among AD subjects with onset age over 70 years. These estimates of the a priori probabilities of dementing disorders have implications for clinicians and researchers.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The goals of this study were to identify the benefits and barriers perceived by family caregivers of persons who have been through a diagnostic assessment for dementia symptoms and to determine which caregivers experience more benefits and barriers associated with assessments. A survey was mailed to caregivers involved in the decision to seek a diagnostic assessment for a family member at a University of Kentucky memory disorders clinic. A total of 528 family caregivers (response rate 71.7%) returned a 4-page survey designed to elicit benefits, barriers, and demographic information. Respondents delayed the diagnostic assessment for an average of 22.4 months after noticing symptoms. Perceived benefits involved confirmation of a medical condition, access to treatment, and help preparing for the caregiving role. Barriers were both emotional and pragmatic in nature. Respondents who were younger, visited the rural assessment clinic, and had less education experienced more barriers. All groups reported receiving the same number of benefits from the assessment. By incorporating these benefits and barriers, interventions can be designed to increase the likelihood of early diagnostic assessments.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The goal of this study was to describe the evolution of dementia severity in a very old dementia population. We investigated a representative group of demented subjects gathered from a population-based study (n= 223). Changes in cognition, functioning, and performance on global scales were followed over a period of 7 years. At baseline, 19% of the demented subjects were found to be severely impaired according to the Clinical Dementia Rating scale, 41% according to the Mini-Mental State Examination score, and 31% according to Katz activities of daily living scale. After 7 years these proportions were 78%, 93%, and 68%, respectively. The probability of surviving 3 years, 5 years, and 7 years after baseline examination was 48%, 28%, and 15%, respectively. Over a 7-year follow-up period, subjects suffering from questionable–mild dementia had a mean survival of 3.9 years (95% confidence interval 3.3–4.5), whereas subjects with severe dementia survived on average 2.9 years (95% confidence interval 2.5–3.2). Male gender, lower education, and poor cognitive and functional status were associated with shorter survival in milder cases, whereas the only factors that predicted shorter survival in more severe cases were older age and poor functional status. Long-term survivors in dementia are not rare, and as the absolute number of demented people is increasing, expanding our knowledge of these persons is of high public health importance.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

A series of tasks assessing inhibitory processes was administered to patients with Alzheimer disease and control subjects. Two groups of patients with Alzheimer disease were examined: patients with hypometabolism restricted to the posterior (temporal and parietal) cerebral areas and patients with hypometabolism in both posterior and anterior (frontal) cerebral areas. The performances of the patients with Alzheimer disease were inferior to those of control subjects on all inhibitory tasks, but the two groups of patients obtained similar scores. These data indicate that frontal lobe hypometabolism is not necessary to produce inhibitory impairment in Alzheimer disease. Consequently, inhibitory dysfunction could be the consequence of a (partial) disconnection process between posterior and anterior cerebral areas.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

We investigated the prevalence of and prognostic factors for functional independence in personal activities of daily living in a population-based sample of 90 seniors with mild dementia from the Canadian Study of Health and Aging. Personal activities of daily living were assessed from the report of proxy respondents at baseline and at the 5-year follow-up (or retrospectively if death had occurred). Sixteen (17.8% of the total group of 90) subjects maintained their personal activities of daily living independence over the full 5-year period or up to 3 months before death (15.1% if the four subjects reclassified as not demented at the second wave are excluded). An age of 75–84 years (vs. those 65–74 years of age and 85+ years of age; odds ratio 12.9, 95% confidence interval 2.7, 112.7), the absence of gait-balance-movement problems (odds ratio 5.2, 95% confidence interval 1.3, 25.8), the presence of extrapyramidal signs (odds ratio 9.5), and fewer years of formal education (odds ratio 3.6) were favorable prognostic factors in our multivariate modeling. An absence of sensory problems was a statistically significant favorable prognostic factor in bivariate analysis. Prior studies on the time required for patients with dementia to progress to functional milestones used clinic-based samples. Our findings, which have potential public health implications, need to be confirmed and expanded upon.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Caregiver burden, the stress experienced as a result of caregiving, is determined by many factors. This study examined the contributions of the patient's awareness of memory deficit and behavioral disturbance to caregiver burden in Alzheimer disease. Participants were 41 patients with Alzheimer disease and their caregivers. Dementia severity, functional impairment, awareness of memory deficit, and behavioral disturbance were measured and examined in relation to caregiver burden. Positive correlations were found between caregiver burden and both impaired awareness of memory deficit and behavioral disturbance. Regression analyses demonstrated that both impaired patient awareness of memory deficit and behavioral disturbance contributed to caregiver burden over and above dementia severity and functional impairment. However, when both were entered together into regression equations, only behavioral disturbance contributed to caregiver burden. Of the problem behaviors, measures of disinhibition contributed most to caregiver burden. These data further our understanding of the multiple contributors to caregiver burden. We conclude that both patient awareness of memory deficit and behavioral disturbance impact caregiver burden, with behavioral disturbance making the greater contribution.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Part of the challenge in research on degenerative neurologic disease relates to distinguishing those measurements that essentially describe patient characteristics stable across the course of illness (traits) from those that vary systematically within subjects (states), particularly those specifically related to stage or duration of illness. A components-of-variance approach was used to examine the state versus trait aspects of the Alzheimer's Disease Assessment Scale (ADAS) Cognitive and Noncognitive subscales, a clinical instrument frequently used in research on Alzheimer disease. Subjects were 190 patients with probable AD followed longitudinally. Stage of illness was indexed by mental status scores. Analysis of variance was used to partition total variance into that associated with subjects (trait), stages (state: stage), subjects × stages (state: other), and error. ADAS Cognitive scores were strongly related to stage of illness (83% of true variance). ADAS Noncognitive scores were modestly related to stage (approximately 21% of true variance) and moderately related to state: other (47%). We discuss how state–trait analyses can be helpful in focusing attention on those areas of assessment most likely to accomplish specific objectives.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Elderly subjects with mild memory impairment but not apparent dementia are the focus of early intervention trials. To examine the effects of structural psychosocial intervention for elderly subjects with very mild Alzheimer disease, i.e., Clinical Dementia Rating 0.5. The design is a prospective study. The experimental group (14 Clinical Dementia Rating 0.5 subjects) and the control group (11 Clinical Dementia Rating 0.5 subjects) were studied. Subjects with cerebrovascular disease as shown by magnetic resonance imaging were excluded. The experimental group participated in activities in a day-care-like setting once a week over a period of 6 months, whereas the control group did not. Each group was reevaluated after approximately 9 months. The effects of intervention were evaluated by cognitive tests, affective scales, a global clinical measure, an observation scale in the sessions, and a projective test. The experimental group showed a significant improvement on the word fluency test, whereas the control group showed a significant decline on the Mini-Mental State Examination, the digit span, and the Trail Making-A test. The experimental group revealed significantly higher levels on the Mini-Mental State Examination and the digit span compared with the control group after the 6-month intervention. A significant improvement was found for the global clinical measure, the observation scale, and the projective test in the experimental group after the intervention. After controlling the potential confounders (age, educational level, baseline cognitive, and affective status) in a multiple regression analysis, the same results were found. We considered that psychosocial intervention had beneficial effects for subjects with very mild Alzheimer disease.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Individuals with Alzheimer disease experience cognitive and behavioral impairments that affect their ability to communicate. In an effort to compensate for these declines, a number of communication strategies have been recommended in the literature for Alzheimer disease caregivers. These include recommendations for caregivers to modify their language behavior and/or the context of communication. The purpose of this study was to (1) review the Alzheimer disease caregiving literature and identify communication strategies commonly recommended for family caregivers and (2) determine how often caregivers report using these strategies and how effective they feel each is in facilitating communication. A review of the literature identified 10 recurring communication strategies. A questionnaire was constructed that asked caregivers to report on the use and efficacy of these 10 strategies. Twenty family (spouse) caregivers of persons diagnosed with Alzheimer disease completed the questionnaire. The results show that caregivers perceived using the 10 strategies, although the strategies appearing most frequently in the literature were not necessarily the ones used most often by caregivers. A positive correlation was observed between caregivers' perceived use of strategies and their effectiveness. Use and efficacy of a strategy did not significantly vary as a function of dementia severity or the gender of the caregiver. The findings provide evidence that caregivers are aware of their communication behavior and modify it in ways that they think improve communication with their spouse.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Recruitment issues pose a major problem in dementia research. This paper aims to clarify issues involved in the recruitment of individuals suffering from dementia for research studies. Five studies conducted by the same research team are analyzed in terms of their recruitment procedures and the obstacles encountered with recruitment. Recruitment rates varied from about 80% to 1%. Rates increased according to perceptions of risk, perceptions of benefits, and exclusion criteria. Pharmacologic studies had much lower recruitment rates than nonpharmacologic studies. Investigators need to limit exclusion criteria as much as possible. The extremely low recruitment rates of pharmacologic studies in frail persons with dementia may render the results irrelevant for that population. Similarly, the major differences in procedures between pharmacologic and nonpharmacologic studies may invalidate comparisons of results among such studies. More attention needs to be given to a systematic reporting of recruitment rates.

ISSN:0893-0341    

出版商:OVID    

年代:2002

数据来源: OVID