|
11. |
A One Year Follow‐Up Study of the Distribution of14C‐Clodronate in Mice and Rats |
|
Pharmacology&Toxicology,
Volume 62,
Issue 1,
1988,
Page 51-53
Jukka Mönkkönen,
Preview
|
PDF (287KB)
|
|
摘要:
Abstract:The distribution of14C‐clodronate (dichloromethylene bisphosphonate) was studied in mice and rats by whole‐body autoradiography and by measuring the14C‐activities in various tissues up to one year after a single intravenous dose. The results indicate that the deposition of clodronate in bone tissue of mice and rats is extremely strong and long lasting; in both animals, high radioactivities were measured even 12 months after the administration. In spleen, thymus, and small intestine of mice,14C‐activity could be detected 12 months after dosing. Small amounts of radioactivity were also detected in spleen of rats for 12 months, although much less than in spleen of mice. The results suggest that clodronate accumulates to some extent in the reticuloendothelial system of animals. They suggest further that the animal species should be carefully considered when interpreting the distribution kinetics of bisphosphonates, especially their accumulation in the reticuloendothelial
ISSN:0901-9928
DOI:10.1111/j.1600-0773.1988.tb01843.x
出版商:Blackwell Publishing Ltd
年代:1988
数据来源: WILEY
|
12. |
Cardiovascular Effects of Doxorubicin (Adriamycin®) and 4‐Demethoxydaunorubicin (Idarubicin®) in the Conscious Rat |
|
Pharmacology&Toxicology,
Volume 62,
Issue 1,
1988,
Page 54-56
P. S. Christoffersen,
K. K. Rasmussen,
K. Hermansen,
Preview
|
PDF (306KB)
|
|
ISSN:0901-9928
DOI:10.1111/j.1600-0773.1988.tb01844.x
出版商:Blackwell Publishing Ltd
年代:1988
数据来源: WILEY
|
13. |
Teratogenicity Test of γ‐Butyrolactone in the Sprague‐Dawley Rat |
|
Pharmacology&Toxicology,
Volume 62,
Issue 1,
1988,
Page 57-58
Tony Kronevi,
Bo Holmberg,
Sivonne Arvidsson,
Preview
|
PDF (195KB)
|
|
ISSN:0901-9928
DOI:10.1111/j.1600-0773.1988.tb01845.x
出版商:Blackwell Publishing Ltd
年代:1988
数据来源: WILEY
|
|