摘要:

This investigationwas designed to gain information on the relative levels of salivary immunoglobulins in patients with acute necrotizing ulcerative gingivitis as compared to patients with clinically healthy gingival tissue. Relative levels of salivary immunoglobulins in diseased and healthy patients were measured and standard antisera to human immunoglobulins were used to detect any host antibody production in both parotid fluid and whole saliva. Salivary samples were analyzed for five classes of immunoglobulins: IgG, IgM, IgA, IgAsec, and IgE. Healthy individuals showed no detectable concentration of IgM or IgE in whole saliva or parotid fluid. IgG, IgA, and IgAsecwere present in all samples. Individuals with acute necrotizing ulcerative gingivitis demonstrated no detectable concentration of IgM in whole saliva or parotid fluid, IgE in normal individuals was not detectable; therefore, it was not included in the acute necrotizing ulcerative gingivitis analysis. There was a decrease in parotid fluid concentrations of IgG, IgA, and IgAsec. Whole saliva showed a decreased concentration of IgG and IgA. The IgAsecconcentration was increased in whole saliva. At the 5% level of significance, the “Students”ttest illustrates that in acute necrotizing ulcerative gingivitis patients IgG, IgA and IgAsecconcentrations in parotid fluid demonstrate a significant difference in relative concentrations as compared to the normal individuals. Whole saliva IgA and IgAsecconcentrations were significantly different. Whole saliva IgG concentrations were not significantly different at this level. The Chi‐square test at the 5% level of significance illustrates the same order of significance as in “Student”ttest, for the relative frequency of salivary immunoglobulins in acute necrotizing ulcerative gingivitis patients as compared to normal individuals. The decreased salivary immunoglobulin concentration observed in acute necrotizing ulcerative gingivitis patients, as compared to normal individuals, suggests that an immune defect—hypogammaglobulinemia—may be the primary factor in the etiology of acute necrotizing ulcerative gingivitis. The increased whole saliva IgAsecconcentration illustrated in acute necrotizing ulcerative gingivitis patients, as compared to normal individuals, suggests that “pathotopic potentiation” may be responsible for such an increase.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.63

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Patients withIgA deficiency and agammaglobulinemia were pair‐matched to immunocompetent subjects by age and Plaque Index. Clinical examinations performed initially and after 2 years included the Plaque Index, Gingival Index, Periodontal Disease Index, caries experience (DMF‐T) and full mouth radiographie surveys. Therapy during the 2‐year period included oral hygiene instructions, prophylaxis and indicated restorative treatment. Immunodeficient patients manifested consistently lower levels of gingival inflammation than matched immunocompetent patients at both examination periods. Caries experience of immunodeficient patients was also less during the study interval, and five of these patients demonstrated DMFT scores of zero. No developmental abnormalities, acute gingival or mucosal lesions, or attachment loss associated with periodontitis was observed in either group.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.70

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Asample of1,003 children, aged 15 years, were examined for prevalence of gingival recession. It was found that 17% had pseudo gingival recession and 1% had true recession. The highest degree of association with local etiological factors was that between recession and the width of keratinized gingiva; frenal pull was the second most highly associated factor followed by tooth arch relationship and the least association existed between plaque and gingival recession. There was no association between calculus and recession.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.74

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Areview of the literatureis presented with regards to the soft tissue‐root surface interface. The basic biological aspects are discussed followed by reports on healing after periodontal surgery. The effect of citric acid, to enhance new attachment, is reviewed in detail. Articles reporting on clinical findings, ultrastructural observation (TEM and SEM), and light microscopic studies have been selected to present the reader with a logical overview of what has been reported in the literature.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.77

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Homogenates wereprepared from sections of both clinically normal and clinically inflamed human gingival tissue. After centrifugation, supernatants were quantitated for protein and subjected to anionic and cationic electrophoresis. Samples of gingival blood and venous blood were similarly subjected to electrophoresis. Significant protein pattern differences are reported for the anionic tissue separations, and for the cationic tissue and plasma separations.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.83

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Protein concentrationsin gingival fluid exudate were obtained in both the clinically minimal and severe inflammatory states. A comparison of the results indicated no significant differences in the two groups studied. Since total protein concentrations do not appear to reflect accurately the clinical inflammatory status of the gingival tissues, specific components of the protein molecule should be studied.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.86

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Total fucose andprotein was measured in gingival fluid samples collected from 16 human subjects. A significantly higher total protein concentration was found for the control (clinically normal) group when compared to the experimental (severe clinical inflammation) group. This is probably due to the higher gingival flow rate found in the experimental group. The total fucose analyses showed no statistical difference between both groups, but when fucose to protein ratios were studied, a significantly higher ratio was found for the experimental group when compared to the controls. This probably represents the breakdown of plasma and tissue glycoproteins which may occur as a result of inflammation.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.88

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

The patient is sufferingfrom Anderson‐Fabry disease. This was documented by family history, clinical findings, histochemical and electronmicroscopic demonstration of ceramide in the blood vessels, and enzyme studies. The patient, at age 17, developed a unique gingival enlargement, gingivitis granulomatosa, a cobbled tongue, glossitis granulomatosa, and a lip enlargement, Cheilitis granulomatosa. This was not found in other members of the family. The clinical, histological, and electronmicroscopic findings were analogous to Melkersson‐Rosenthal syndrome. The patient did not have sarcoidosis or other specific granulomatous diseases. These were ruled out by skin examination, chest films, histology, and skin sensitivity testing, nor did he have Dilantin associated gingival enlargement. The patient had only taken the drug for a brief period at age 11 when he had a generalized granulomatous lymphadenopathy which was not categorized with certainty. This could have been secondary to Anderson‐Fabry disease aggravated by a minor infection, an idiosyncratic reaction to Dilantin, or the lymph node equivalent of the granulomatous response that later affected the gingiva. Although the gingival enlargement appeared to be a manifestation of an unusual syndrome, local therapy in the form of oral hygiene instruction, dental prophylaxis, gingivectomy, and regular maintenance therapy was successful in treatment and prevention of recurrence.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.95

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

The immunogenicityof allogeneic sclera was tested in a rabbit model system. Twelve linebred New Zealand rabbits were injected with various doses of a crude homogenate of allogeneic sclera suspended in complete Freund's adjuvant. The eyes were observed grossly and histologically for inflammatory changes indicative of autoimmune responsiveness for up to 10 weeks after the first injection. Control and test animals were sacrificed and their lymphoid cells tested in vitro for sensitivity to scierai antigens. Delayed hypersensitivity to sclera antigens was evaluated and sera examined for antibody to sclera. No evidence of autoimmunity to the animals eyes in either test or control rabbits was noted. Lymphocyte cultures from all but one appeared inhibited by the presence of the sclera. The addition of microgram concentrations of either the crude sclera homogenate or soluble substances obtained by centrifugation of the homogenate to lymphocyte cultures inhibited mitogen‐induced DNA synthesis by 46 to 91%. Sclera appears to be a weak immunogen. It is conceivable that allogeneic sclera could be a more potent immunogen in animals of a specific genetic constitution. Sclera may modulate the immune response by activating a suppressor mechanism and this activation may play a role in the lack of immune responsiveness clinically observed in vivo.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.102

出版商:Wiley    

年代:1980

数据来源: WILEY

摘要:

Five patientsreceived a Proplast implant in combination two‐ and three‐wall osseous defects. In four of the cases the implant material was removed within 6 weeks due to failure to maintain primary closure over the Proplast and subsequent inflammation. One implant remained in place for 6 months with no apparent visual signs of inflammation. However, an 8 mm pocket remained, the area was reentered, and histologie sections made. The histologic sections revealed Proplast intermixed with bone, and the presence of foreign body giant cells.

ISSN:1049-8885    

DOI:10.1902/jop.1980.51.2.110

出版商:Wiley    

年代:1980

数据来源: WILEY