摘要:

AbstractSignificantly higher density of intramembranous particles (IMP) was noted in the endothelial plasma membrane facing the blood‐front compared to the tissue‐front. The difference may be related to the function of the vascular endothelium as an active barrier between the blood and the tis

ISSN:0002-9106    

DOI:10.1002/aja.1001510112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractUltrastructural changes in thyroid follicular cell morphology were studied following the infusion of thyrotropin‐releasing hormone (TRH) for 1 min into a hypophysial stalk portal vessel of adult male rats. At 1, 5, 15 and 30 min following infusion, thyroid glands were removed and prepared for electron microscopic examination. Thyroid follicular cells in unoperated, sham‐operated non‐infused, and saline‐infused control rats were cuboidal, generally lacked intracellular colloid droplets and contained variable numbers of electron‐dense lysosome‐like bodies distributed throughout the cytoplasm. In experimental animals, marked intracellular colloid droplet accumulation was observed 5 min after TRH infusion and remained a constant finding throughout the time‐periods studied. Numerous lysosome‐like dense bodies accumulated in the apical cytoplasm of thyroid follicular cells at 30 min. Fusion of colloid droplets and lysosome‐like bodies had apparently occurred by 30 min. At this time the colloid droplets were smaller, more electron‐dense and were often located more basally within the follicular cell cytoplasm. This study suggests that the morphological response of thyroid follicular cells to hypophysial portal vascular infusion of TRH occurs rapidly and mimics, both temporally and morphologically, the response observed following systemic administrati

ISSN:0002-9106    

DOI:10.1002/aja.1001510113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

ISSN:0002-9106    

DOI:10.1002/aja.1001510101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY