ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03283.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03284.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

ABSTRACTNine dogs received a course of megestrol acetate, 2 mg/kg/day for 14 days and then 1 mg/kg/day for a further 14 days, as part of a programme to modify undesirable behaviour. Adrenocortical function was monitored using the adrenocorticotrophin (ACTH) stimulation test before treatment, on days 14 and 28 of treatment and then on days 42 and 70. The mean basal Cortisol concentration was significantly (P<0.01) lower than the pre‐treatment value on days 14 and 28. The mean post ACTH stimulation Cortisol concentration was significantly lower than the mean pre‐treatment post ACTH Cortisol concentration on days 14 and 28 (P<0.01), on day 42 (P<0.001) and on day 70 (P<0.

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03285.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03286.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

ABSTRACTThe efficacy of radioactive iodine (131I) administration was studied in a series of 50 hyperthy‐roid cats. The dose administered to each cat was based on the clinical severity of the thyrotoxicosis, the serum total thyroxine (TJ concentration and the size of the goitre estimated by palpation. The activity ranged from 80 to 200 MBq (mean ± SD, 143 ± 24 MBq}. The131I was injected intravenously in 27 cases and subcutaneously in 23 cases. Each cat was hospitalised for 30 days after the injection. Regardless of the route of injection, none of the cats exhibited any side effects after therapy and all tolerated the hospitalisation period well. There was a significant (P<0.001) decrease in the serum total T4concentration (reference range, 10.4 to 42.0 nmol/litre) from a mean ± SD of 181.3 ± 111.4 nmol/litre (range, 43.8 to 575.6 nmol/litre) to a mean ± SD of 19.0 ± 29.6 nmol/litre (range, 2.0 to 175.7 nmol/litre) 30 days following the injection of the radioisotope. Five cats remained hyperthyroid, although in each case the serum total T4concentrations had decreased from pre‐treatment values. Two of the cats subsequently became euthyroid within three and five months of therapy, respectively, two were lost to adequate follow‐up and the remaining cat was successfully retreated four months later. Before treatment, four of these cases had high scores based on the three criteria used for dose estimation. Serum total T4concentrations below the reference range developed after treatment in many cases, but were often transient. Clinical evidence of hypothyroidism was not apparent in any cat. Recurrence of hyperthyroidism has not occurred in follow‐up periods of up to 32 months. There was no difference in the outcome between the cats injected intravenously or subcutaneously and the latter was considered to be safer and simpler. The administration of an approximated dose of131I proved to be an effective treatment for hyperthyroidism in 47 (94.0 per cent) of the cats and obviated the need for sophisticated nuclear computer facilities. There may be a lag period in some cases before euthy‐roidism is achieved and this should be considered before the administration of a second dose.131I can be administered subcutaneously without u

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03287.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

ABSTRACTThe medical records of 12 cats presented with intussusception and diagnosed at the University of Sydney Veterinary Teaching Hospital and the Sylvania Veterinary Hospital were reviewed. Eleven cats were less than one year old at the time of diagnosis. No breed or sex predilections were determined. The most consistent clinical signs were anorexia (83 per cent), weight loss (83 per cent) and a palpable abdominal mass (92 per cent). Vomiting (58 per cent) and diarrhoea (50 per cent) were seen less frequently in these cats compared with the reported incidence of these signs in dogs. In 10 cats the intussusception was corrected surgically. Manual reduction was successful in three of the cats but six required end‐to‐end anastomosis following intestinal resection and in one cat a typhlectomy was performed. Postoperative ileus complicated recovery in three cases. Recurrence of the intussusception at a different site occurred in two of these cases. One cat with recurrence of intussusception died and the cat with ileus but not recurrence was euthanased one month after the original surg

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03288.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03289.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

ABSTRACTThe ceroid‐lipofuscinoses are a group of inherited neurodegenerative diseases of humans and animals characterised by the accumulation of a fluorescent lipopigment in neurons and other cells within the body. Syndromes occurring in dogs are classified, on the basis of the age of onset and, to a lesser degree, the course of the disease, as prepubertal‐protracted, early adult acute and adult onset. Clinical signs are generally those of progressive loss of vision, motor disturbances such as ataxia, tremors, seizures and proprioceptive deficits together with behavioural changes including loss of learned behaviour, fearfulness and aggression. The various syndromes can be expected to reflect different mutations, at least some of which affect the catabolism of subunit c of mitochondrial adenosine triphosphate (ATP) synthase. Confirmation of diagnosis depends on the demonstration of lipopigment in brain or skin biopsies by histochemistry, fluorescence or electron microsc

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03290.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03291.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

ABSTRACTTotal acid phosphatase (TAP), prostatic acid phosphatase (PAP) and non‐prostatic acid phosphatase (NPAP) serum concentrations were determined using a spectrophotometric technique in 52 healthy dogs, 15 male dogs suffering from non‐prostatic diseases and in 19 dogs suffering from prostatic diseases (12 dogs with benign prostatic hypertrophy and seven dogs with prostatic adenocarcinoma). TAP, PAP and NPAP serum concentrations did not differ between normal male and normal female dogs. Dogs with prostatic adenocarcinoma had significantly higher TAP, PAP and NPAP serum concentrations than dogs with benign prostatic hypertrophy, normal dogs and dogs with non‐prostatic disease. The authors conclude that low serum concentrations of TAP and PAP do not rule out prostatic adenocarcinoma in the dog, but elevated concentrations can be useful criteria for the diagnosis of canine prostatic c

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1994.tb03292.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY