ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01116.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTHyperchylomicronaemia was identified in a four‐week‐old Siamese kitten with lethargy, in‐appetence, hindlimb ataxia and profound anaemia. The kitten was euthanased and at necropsy a thrombus was found occluding the caudal aorta. Two littermates later presented with lethargy, inappetence and hypertriglyceri‐daemia which resolved after being weaned on to a low fat diet. A similar condition was subsequently diagnosed in a kitten born to the same sire but a different queen. The expression of hyperchylomicronaemia in two related litters was suggestive of an inherited, familial defect in the function of lipoprotein lipase (LPL). The activity of this enzyme was reduced in all three parents, the two recovered cases and two related, but apparently unaffected kittens, compared with a control group of unrelated cats belonging to the breeder. This reduction in activity was not attributable to defective activation of LPL by its serum cofactor apolipoprotein C‐II or the presence in plasma of a factor that inhibited LPL. The gene that codes for LPL was examined by restriction fragment length polymorphism analysis using a human LPL cDNA probe. The results showed that the cat has a similar, but not identical, LPL gene to man. However, there were no differences in the restriction fragment patterns obtained from affected, unaffected and contro

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01117.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01118.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTDietary therapy should be designed to enhance insulin therapy and improve glycaemic regulation of the diabetic dog and cat. Dietary therapy will not alleviate the necessity for insulin therapy in dogs and cats with insulin‐dependent diabetes mellitus. Preliminary work suggests that dietary therapy may ultimately be the only therapy necessary to maintain glycaemic control in cats with suspected non‐insulin‐dependent diabetes mellitus. Currently, the feeding of a high fibre, high complex carbohydrate diet is recommended at a caloric intake designed to correct obesity and maintain ideal bodyweight. Several small meals should be fed during the period of insulin activity, to help minimise post prandial fluctuations in the blood glucose concentr

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01119.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTA condition characterised by the early onset of vestibular deficit and hearing loss was investigated in the dobermann breed of dog. Affected pups showed behavioural signs of head tilt, circling and ataxia and there was a total absence of vestibular response to rotation or caloric stimulation. Severe deafness, as assessed by brainstem auditory evoked response testing, was present by three weeks of age in all affected animals. The inner ears showed a progressive neuroepithelial type of cochlear degeneration with loss of the auditory sensory cells. In the vestibular system, however, there was no equivalent sensory cell loss and the only abnormal feature was the absence or abnormality of the otoconia in some of the affected animals. Pedigree analysis suggested that the condition was inherited as an autosomal recessive trait.

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01120.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTEighteen total ear canal ablations combined with lateral bulla osteotomy (TECA/LBO) procedures were performed in 15 cats over a period of 30 months. The indications for surgery included neoplastic disease, ceruminous gland adenocarcinoma of the horizontal canal or middle ear (10 ears), squamous cell carcinoma extending from the pinna (four), polyps emanating from the middle ear (three), and chronic unremitting middle ear disease (one). Complications associated with surgery included facial paralysis (seven cases), facial neuropraxia (four), Horner's syndrome (three), and wound dehiscion (one). Eleven cats were alive and disease‐free six months after the surgery. The results indicate that the major indication for TECA/LBO in the cat is neoplastic disease involving the ear. Unlike the procedure in the dog, for which the usual indication is benign end‐stage ear disease, neurological complications are common despite meticulous surgical dissections. In addition, the postoperative prognosis is guarded because of malignant disease in many ca

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01121.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTThe efficacy and safety of carbimazole (CBZ) was studied in a series of 45 hyperthyroid cats. CBZ was used before surgical thyroidectomy in 34 cats, at a dose of 5 mg administered orally every eight hours. Biochemical euthyroidism, as assessed by a decrease in serum total thyroxine (T4) concentrations into the reference range, was achieved in 31 cats (91 per cent) within a mean (± SD) of 5–7 (± 2–9) days (range, three to 15 days). Clinical evidence of euthyroidism tended to lag behind biochemical evidence but was usually apparent after 14 days. Continuing therapy tended to decrease serum total T4but not serum total triiodothyronine (T3) concentrations below the reference range but clinical evidence of hypothyroidism was not apparent. In five additional cats, 5 mg CBZ was administered three times between 08.00 and 20.00 hours. Euthyroidism was achieved in only one cat after 14 days, emphasising the need for eight hourly dosing. Clinically observable side effects developed in five cats (13 per cent), two to three weeks after commencing therapy and included vomiting (n y 2) and vomiting and anorexia (n = 3). In three cases withdrawal of CBZ was required. Mild and transient haematological abnormalities developed in two cats (one case each of lymphocytosis and leucopenia). There were significant decreases in serum concentrations of alanine aminotransferase and alkaline phosphatase in those cats achieving euthyroidism (P<0–001 in each case) but not in those that remained hyperthyroid despite CBZ therapy (P ± 0–05 in each case). CBZ was used as the sole therapy for the condition in eight cats for between four and 65 weeks. A consistent dosage of 5 mg CBZ administered twice daily was necessary to maintain euthyroidism. Adverse reactions were not noted. Chronic medical management tended to depress serum total T4concentrations below the reference range. Corresponding serum total T3concentrations remained within the reference range on 15 (88 per cent) of 17 occasions and may explain why the animals appeared clinically euthyroid. CBZ appears to be a safe and effective drug both in the short and long term management of feline hyperthyroidism and can be recommended as the current drug of choice

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01122.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01123.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTA two‐year‐old chihuahua bitch was presented with urinary incontinence following ovariohysterectomy which had been performed at the time of caesarean section. Clinical, contrast radiographic and surgical investigation revealed the presence of right hydroureter and hydronephrosis, vesicovaginal fistula and absence of most of the urinary bladder. These abnormalities appeared to have resulted from ligation of the caudal bladder, at the level of the trigone, during ovariohysterect

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01124.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1992.tb01125.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY