摘要:

ABSTRACTEssential fatty acids (EFAs) are important in the maintenance of epidermal barrier function, as components of cell membranes and as precursors of prostaglandins, leukotrienes, thromboxanes and other substances involved in mediating inflammation. There is increasing evidence that dietary supplementation with certain EFAs, notably gamma‐linolenic acid (GLA) and eicosapentanoic acid (EPA), can have anti‐inflammatory actions. In man, it has been shown that supplementation with evening primrose oil (EPO), a source of GLA, can ameliorate atopy. Recent studies in the dog indicate that both EPO and cold water marine fish oil (containing EPA) can ameliorate allergic skin disease and improve skin and coat condition. EFA supplementation also promises to be useful in the treatment of seborrhoea and other conditions in the

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01537.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01538.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTIn the United Kingdom, most cases of zinc‐responsive skin disease in dogs result from feeding soya and, or, cereal‐based diets, possibly, in some animals, in association with an apparent inherent defect of zinc absorption. Most such diets are not deficient in zinc but contain excessive quantities of other substances which reduce its availability for absorption. Important clinical signs include a dull, harsh coat with or without achromotrichia, erythema, seborrhoea sicca, bilaterally symmetrical, circular to linear, white/yellow crusts affecting the head, limbs, scrotum and perineum, ceruminous otitis and peripheral lymphomegaly. The diagnosis is suggested by the history, physical signs, laboratory tests and the examination of skin biopsies and is confirmed by an unequivocal response to oral zinc supplementation (10 mg/kg zinc sulphate once daily with food) while keeping the original diet unchanged. Non‐specific laboratory tests (serum alkaline phosphatase, cholesterol and thyroxine concentrations before and after thyroid stimulating hormone administration) reported by others as being abnormal in some cases of zinc‐responsive dermatosis have been unhelpful but a plasma zinc concentration below the mean of the reference range supports the diagnosis. The classical histological change of zinc‐responsive dermatoses, parakeratosis, has been seen in only 64 per cent of cases biopsied. Long term management necessitates a change in diet to canned meat and biscuit. Long term therapy is not required. Many manufacturers of diets predisposing to the condition are now adding additional zinc to their diets resulting in a dramatic reduction in the numbers of new cases of the condition b

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01539.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTPyoderma is commonly seen in canine veterinary practice and usually occurs as a complicating factor in other primary conditions. Allergic skin disease is often the underlying cause but the precise relationship between allergy and infection is unknown. Our studies have investigated the relationship between bacterial proliferation at the skin surface and hypersensitivity reactions with the skin. Hypersensitive dogs were shown to have significantly higher surface counts of staphylococci than normal controls and these bacteria were concentrated in the more superficial layers of the stratum corneum. Intradermal injection of staphlococcal antigens in normal dogs elicited epidermal damage similar to that seen in clinical disease. Preliminary autoradiographic studies using a model of canine skin hypersensitivity reactions showed that percutaneous absorption of radiolabelled staphylococcal antigens was increased by mast cell degranulation. These findings suggest that a major role of hypersensitivity reactions in the pathogenesis of pyoderma may be via an effect on epidermal permeability, promoting penetration of staphylococcal antigens from the stratum corneum which then cause the lesions of pyoderma. Hypersensitivity reactions may also lead to changes in the skin surface microclimate leading to increased bacterial counts on the skin surface, so exacerbating the condition.

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01540.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01541.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTThe pathomechanism of canine and feline atopy has not been totally defined. Immunotherapy has been shown to be effective. The diagnosis of canine and feline atopy is still fraught with complications. Several new drugs may be useful in the treatment of canine and feline atopy.

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01542.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTThe clinical signs associated with non‐bullous and bullous immune‐mediated diseases are discussed, together with diagnostic procedures. The methods of treating, or suppressing, these autoimmune diseases are also outli

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01543.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01544.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTThe clinical features of eosinophilic granuloma complex are discussed together with any possible links to underlying causes of the disorder such as food hypersensitivity. Typical histopathological observations and therapy are also outlined.

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01545.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1989.tb01546.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY