摘要:

ABSTRACTThe purpose of this investigation was to evaluate the significance of enzymatic and biochemical analyses in the classification of chronic inflammatory liver disease and to evaluate the prognosis of these diseases. Chronic hepatitis and cirrhosis were diagnosed by histopathological examination in 79 dogs. Decreased appetite and lethargy were the most common owner complaints (46/79). Vomiting and, or, diarrhoea were reported in 27/79 dogs. Ascites was the most common clinical sign (43/79), whereas icterus was a more unusual finding demonstrated in 16/79 dogs. Liver cirrhosis was diagnosed most frequently, in 33/79 dogs, followed by chronic progressive hepatitis (22/79), chronic cholangiohepatitis (13/79), and chronic non‐specific hepatitis (11/79). Hypoalbuminaemia was the most consistent biochemical aberration in liver cirrhosis (25/26) and in chronic progressive hepatitis (13/18). These diseases also showed normal to mildly increased concentrations of serum alanine aminotransferase (ALT) and serum γ‐glutamyl transferase (GGT) and a moderate to marked increase of serum alkaline phosphatase (ALP) and fasting serum bile acid (SBA) concentrations. As expected, icterus and markedly elevated ALT, ALP, GGT and SBA levels were demonstrated in chronic cholangiohepatitis. In this disease hypoalbuminaemia was shown in 6/12 dogs, whereas in dogs with chronic non‐specific hepatitis, mean SBA and albumin concentrations were normal. In liver cirrhosis the prognosis was poor, with 94 per cent of the dogs dead within one week of established diagnosis. For dogs with the other types of chronic hepatitis the prognosis was more favourable with the mean survival time ranging from 21‐1 to 36

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02801.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02802.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

ABSTRACTCanine food allergy can be defined as a non‐seasonal, pruritic skin disorder of dogs that is associated with the ingestion of a substance found in the dog's diet. This study records the use of a proprietary dried fish, corn and soyabased diet for the investigation and maintenance of food allergic dogs when fed initially as a restricted allergen diet and then as a maintenance diet after challenge. All the dogs showed evidence of pruritic skin disease and in addition demonstrated gastrointestinal signs. These included the presence of faecal mucus and blood, tenesmus and increased faecal frequency; all the signs associated with colitis. Both cutaneous and gastrointestinal signs resolved when an elimination diet was fed and could be reproduced when the animal was appropriately challenged. Ten dogs were trailed on a home cooked diet of fish and potato and 10 dogs on the proprietary complete food. All the dogs were challenged to identify their food allergies. Nineteen of the dogs have subsequently been successfully maintained on the proprietary foo

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02803.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02804.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

ABSTRACTThe aim of this study was to titrate the optimal dose of carprofen for single dose usage, for alleviating postoperative pain, under a double‐blind and randomised protocol, using both negative and positive controls. Renal tolerance was assessed by screening plasma urea and creatinine. Pre‐ and postoperative assessment of pain and sedation was made using a dynamic and interactive visual analogue scoring system in 60 cats undergoing ovariohysterectomy. The cats were randomly assigned to one of six groups: (1) carprofen at 1‐0 mg/kg subcutaneously (sc); (2) carprofen at 2‐0 mg/kg sc; (3) carprofen at 4‐0 mg/kg sc; (4) pethidine at 5‐0 mg/kg intramuscularly (im), (5) pethidine at 10‐0 mg/kg im; and (6) no analgesics (injection of saline). All injections were given postoperatively on tracheal extuba‐tion and administered in a double‐blind manner. Assessments were made up to 20 hours post extubation. Prior to induction and at 20 hours post extubation, blood samples were taken for laboratory analysis of the urea and creatinine content to check for any adverse effect on renal function. Cats given pethidine did not appear more sedated than the groups receiving carprofen or saline. Cats receiving carprofen were in less pain postoperatively overall, with 4‐0 mg/kg being the most effective dose rate (significantly better than the other doses of carprofen at four and eight hours post extubation). The highest dose of pethidine provided significantly better analgesia than the highest dose of carprofen up to two hours post extubation, but from two to 20 hours post extubation carprofen at 4‐0 mg/kg provided significantly better analgesia than the pethidine. None of the analgesic regimens appeared to affect renal function adversely, as measured by urea

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02805.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02806.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

ABSTRACTPeriodontal disease is rare in nature but widespread in domestic dog and cat populations. Unnatural diets are known to facilitate the buildup of oral microbial communities which then interact with host‐immune defences giving rise to periodontitis. Eight of 14 animals undergoing dental treatment and dietary change at a suburban veterinary practice were investigated and found to have low leucocyte counts. Follow‐up testing revealed changes averaging a77·7per cent increase with concomitant ‘subjective good health’. These findings serve to cast doubt on the commonly used haematological reference ranges where the subject animals may have suffered from periodontal disease. The demonstrated reversibility of white cell depression associated with periodontal disease should provide a focus for further

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02807.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02808.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

ABSTRACTOn the basis of clinical observations, Irish wolfhounds were suspected as being subject to a relatively high incidence of soft testicular consistency and low semen quality. Thirty‐seven Irish wolfhounds and 67 dogs of other breeds (control group) were therefore examined. Conventional andrological studies were performed in both groups, these included libido testing, palpation and measurement of testes and semen evaluation. Semen evaluation was performed both manually and by videomicrographic analysis. Testosterone concentrations were measured both before and after human chorionic gonadotropin challenge in the Irish wolfhounds. The Irish wolfhounds had lower libidos than the control group. More Irish wolfhounds (21‐2 per cent) exhibited low semen quality than the control group (6‐1 per cent). Soft testicular consistency occurred more frequently in Irish wolfhounds (25‐7 per cent) than in the control group (10‐5 per cent). In the control group, bodyweight correlated significantly with total sperm count. Serum testosterone concentration did not correlate with semen quality p

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02809.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0022-4510    

DOI:10.1111/j.1748-5827.1995.tb02810.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY