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11. |
The Association of HLA-B5 Antigen with Specific Manifestations of Behçet’s Disease |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 293-295
G. Azizlerli,
V.L. Aksungur,
R. Sanca,
E. Akyol,
C. Övül,
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摘要:
The HLA-B5 phenotype was investigated in 235 patients with Behçet’s disease and in 100 healthy persons. HLA-B5 was more frequent in the patients (77 vs. 30% p < 0.001, relative risk = 7.8). The frequency of HLA-B5 was higher in patients with genital ulceration than without (82.3 vs. 63%, p < 0.01). Patients with thrombophlebitis showed a less frequent positivity of HLA-B5 antigen than the patients without thrombophlebitis (50 vs. 79.2%. p < 0.02). These results suggest that HLA-B5-related genes not only affect the development of Behçet’s disease but also the occurrence of its clinical manifesta
ISSN:1018-8665
DOI:10.1159/000247169
出版商:S. Karger AG
年代:1994
数据来源: Karger
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12. |
Semiquantitative Aspects of Mast Cells in Normal Skin and in Neurofibromas of Neurofibromatosis Types 1 and 5 |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 296-299
M. Nürnberger,
I. Moll,
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摘要:
Mast cells are supposed to influence the growth of neurofibromas, because some of their mediators may also act as growth factors. Accordingly, mast cell stabilizers are claimed to reduce proliferation and itching of neurofibromas. Therefore, we quantified the mast cells of 19 neurofibromas and compared them with normal skin. We saw a statistically significant increase in mast cells in neurofibromas versus normal skin. However, there is no correlation between the age of neurofibromatosis (NF) patients and mast cell density. In our study the density of mast cells in neurofibromas is also independent of NF type, age of neurofibroma and chronic ultraviolet exposure in contrast to normal skin. Different tumors of the same patient had similar mast cell counts.
ISSN:1018-8665
DOI:10.1159/000247170
出版商:S. Karger AG
年代:1994
数据来源: Karger
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13. |
Rapid Diagnosis ofChlamydia trachomatiswith a Nucleic Acid Probe in Male and Female Patients |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 300-304
A. Stary,
W. Kopp,
B. Zahel,
I. Müller,
S. Nerad,
M. Storch,
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摘要:
To evaluate a commercially available DNA hybridization test, the Gen-Probe Pace 2 assay (GP) was compared with the Chlamydiazyme (CZ) for the detection of Chlamydia trachomatis in urethral and endocervical specimens. Samples were collected from 300 persons, including 199 registered and 43 nonregistered female prostitutes, examined for screening purposes, as well as 22 male and 36 female symptomatic sexually transmitted disease (STD) patients. The overall prevalence of C. trachomatis was 7.3% in all persons examined with an infection rate of 20.9% in the nonregistered prostitutes, 2.5% in the registered prostitutes and 13.8% in the STD patients. The overall concordance of both diagnostic methods was 98.7% in all samples examined, 100% in male and 98.6% in female samples. Specimens with discordant results were further analyzed by a direct immunofluorescence test (MicroTrak) and by the probe competition assay (PCA). All samples only positive in the GP assay could be confirmed by the PCA while one result which was positive in the CZ could not be confirmed by any other test. The GP assay was superior to the CZ, when compared with true-positive and -negative results. The data demonstrate that the GP assay can be recommended as an alternative diagnostic technique to the CZ for Chlamydia diagnosis.
ISSN:1018-8665
DOI:10.1159/000247171
出版商:S. Karger AG
年代:1994
数据来源: Karger
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14. |
Localization of Perform in Viral Vesicles and Erythema multiforme |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 305-309
K. Sayama,
Y. Watanabe,
M. Tohyama,
Y. Miki,
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摘要:
Background: Perforin (Pf), a pore-forming protein, is a cytolytic protein of killer cells. Its deposition in lesioned skin has not been studied. Objective: The purpose of this study is to show Pf deposition in the lesioned skin and Pf expression in the dermal infiltrates of various inflammatory skin diseases. Methods: Frozen specimens obtained from 29 patients with 5 different diseases were immunohistochemically stained. Results: Granular deposition of Pf was found in the lesioned skin in 2 out of 5 cases of viral vesicles and in 3 out of 7 cases of erythema multiforme. In the cases with Pf deposition, the percentages of Pf+ cells in the dermis were higher than in those without deposition. Conclusion: Pf released from natural killer cells or cytotoxic T lymphocytes may play a role in tissue damage.
ISSN:1018-8665
DOI:10.1159/000247172
出版商:S. Karger AG
年代:1994
数据来源: Karger
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15. |
Flame Figures in Bullous Pemphigoid |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 310-312
T.W. Beer,
J.A.A. Langtry,
W.G. Phillips,
F. Wojnarowska,
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摘要:
We report a patient with bullous pemphigoid showing prominent flame figures on skin biopsy. Although flame figures are the histological hallmark of eosinophilic cellulitis, they are occasionally seen in a variety of other dermatoses.
ISSN:1018-8665
DOI:10.1159/000247173
出版商:S. Karger AG
年代:1994
数据来源: Karger
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16. |
Unusual Coexistence of Systemic Lupus erythematosus and Primary Biliary Cirrhosis |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 313-317
F. Nachbar,
H.C. Korting,
R.M. Hoffmann,
M. Kollmann,
M. Meurer,
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摘要:
Systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report on a 65-year-old woman with coexistence of both conditions. Diagnosis of SLE was ascertained by the presence of seven ACR criteria (cutaneous lesions, photosensitivity, antinuclear and anti-double-stranded-DNA antibodies, pancytopenia, arthritis, oral lesions). PBC was disclosed by clinical investigation, liver histology and highly positive antimitochondrial M2 antibodies. The most important differential diagnoses of lupus hepatitis are PBC and autoimmune hepatitis. Diagnostic criteria for these conditions are discussed, and previous reports on overlap between SLE and PBC are reviewed.
ISSN:1018-8665
DOI:10.1159/000247174
出版商:S. Karger AG
年代:1994
数据来源: Karger
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17. |
A Case of Hutchinson-Gilford Progeria Syndrome Mimicking Scleredema in Early Infancy |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 318-321
N. Erdem,
A.T. Güneş,
O. Avci,
E. Osma,
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摘要:
We report a case of Hutchinson-Gilford progeria syndrome (HGPS). The patient showed the characteristics of scleredema at the age of 2.5 months but developed all the manifestations of HGPS gradually until 10 months old. The possibility of development of HGPS should by considered in any case of scleredema at birth or in early infancy.
ISSN:1018-8665
DOI:10.1159/000247175
出版商:S. Karger AG
年代:1994
数据来源: Karger
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18. |
Primary Rhabdoid Tumour of the Skin in a 14-Month-Old Child |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 322-325
A. Boscaino,
V. Donofrio,
L. Tornillo,
S. Staibano,
G. De Rosa,
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摘要:
We report on a primary cutaneous rhabdoid tumour in a 14-month-old child, to the best of our knowledge, the second case in the literature. The tumour showed a multipolypoid gross appearance and classical histological features. The neoplastic cells were positive for keratin and vimentin and most were positive for proliferating cell nuclear antigen. The ultrastructural examination revealed typical intracytoplasmic aggregates of intermediate filaments. The tumour showed a very aggressive course, and the child died 5 months after the diagnosis of cerebral metastasis.
ISSN:1018-8665
DOI:10.1159/000247176
出版商:S. Karger AG
年代:1994
数据来源: Karger
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19. |
Papuloerythroderma and Cutaneous T Cell Lymphoma |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 326-328
Dwyera NIL,
R.S. Chapman,
G.D. Smith,
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摘要:
An 83-year-old man had the typical cutaneous features of papuloerythroderma of Ofuji. There were reduced numbers of lymphocytes and platelets in his peripheral blood but the eosinophil count was normal. Skin biopsy showed a non-diagnostic infiltrate of T lymphocytes in the dermis. Treatment with topical steroids and UVB phototherapy was ineffective. Twelve months after presentation, a further skin biopsy revealed atypical lymphoid cells invading the epidermis and the skin adnexae. A diagnosis of malignant lymphoma was made; no evidence of extracutaneous spread was found. Photochemotherapy produced rapid resolution of the skin eruption and clearance of the cutaneous infiltrate. Papuloerythroderma may be a manifestation of a cutaneous lymphoma.
ISSN:1018-8665
DOI:10.1159/000247177
出版商:S. Karger AG
年代:1994
数据来源: Karger
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20. |
Plasmasorbent Therapy with Activated Charcoal Column for Congenital Erythropoietic Porphyria |
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Dermatology,
Volume 188,
Issue 4,
1994,
Page 329-330
K. Tanigawa,
H. Namba,
A. Ohtsuru,
M. Shima,
K. Nakata,
M. Kondo,
S. Yamashita,
S. Nagataki,
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ISSN:1018-8665
DOI:10.1159/000247178
出版商:S. Karger AG
年代:1994
数据来源: Karger
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