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| 11. |
Effects of Intravenous and Intracutaneous Bacillus Calmette-Guérin Application on the Drug-Metabolizing System of the Liver |
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Dermatology,
Volume 160,
Issue 2,
1980,
Page 135-141
Thomas Ruzicka,
Günter Goerz,
Wolfgang Vizethum,
Josef Kratka,
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摘要:
Both single intravenous and repeated intracutaneous injections of bacillus Calmette-Guérin (BCG) resulted in alteration of the hepatic microsomal drug-metabolizing enzymes of the rat liver. The cytochrome P-450 content was not significantly altered; its activity (ethoxycoumarin O-dealkylation) was inhibited in both the intravenous and intracutaneous group. The arylhydrocarbon-hydroxylase and aminopyrine-demethylase activities were also diminished; decrease of cytochrome-c-reductase activity was noted after intravenous application only. Comparison of the results for the intravenous and intracutaneous application routes respectively showed qualitative and quantitative differences. The inhibitory effects of BCG treatment on the drug-metabolizing enzymes of the rat liver can only partly be explained by changes in the cytochrome P-450 system. These findings might lead to reconsideration of dosage of drugs in cancer (malignant melanoma) patients treated by combined chemoimmunotherapy
ISSN:1018-8665
DOI:10.1159/000250487
出版商:S. Karger AG
年代:1980
数据来源: Karger
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| 12. |
Purpuric Pityriasis Rosea |
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Dermatology,
Volume 160,
Issue 2,
1980,
Page 142-144
Julian Verbov,
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PDF (469KB)
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摘要:
Occasional cases of pityriasis rosea show few or many purpuric lesions and 3 patients with such lesions are described.
ISSN:1018-8665
DOI:10.1159/000250488
出版商:S. Karger AG
年代:1980
数据来源: Karger
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