摘要:

Azelaic acid is a therapeutic agent with well-known antibacterial properties, but its antimycotic effect has not yet been investigated systematically. In this study we have used an agar dilution technique to test the inhibitory effect of azelaic acid upon common dermatophytes, Scopulariopsis brevicaulis, Candida albicans, Candida glabrata and Pityrosporum ovale. As a result, the growth of dermatophytes and S.brevicaulis was suppressed by 0.56% azelaic acid and that of P. ovale by 1%. By 4% azelaic acid Cglabrata was inhibited completely, but C. albicans still maintained some growth. The antimycotic effect of azelaic acid occurred at pH values between 4.8 and 5.5, whereas its disodium salt had no such effect at pH 6.1. Considering the favorable pharmacological data of azelaic acid, our results give reason to investigate the antimycotic effect of this agent in vivo.

ISSN:1018-8665    

DOI:10.1159/000247303

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We report a case of fingernail onychomycosis in an immunosuppressed renal transplant patient who was successfully treated with once-weekly fluconazole therapy. Relapse did not develop over the 2-month follow-up period. There were no adverse effects from therapy and the cyclosporin dose did not require adjustment. This case suggests that fluconazole may play a role in the treatment of onychomycosis with once-weekly dosing schedules. Future large-scale clinical trials are indicated to fully evaluate its safety and efficacy in onychomycosis.

ISSN:1018-8665    

DOI:10.1159/000247304

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Six male patients with severe psoriatic arthritis (PA) unresponsive to various topical and systemic therapies have been treated with oral cyclosporin A (CyA; Sandimmun®) solution at daily doses ranging usually from 1.5 to 5.0 mg/kg. In 1 case the dose had to be increased to 7 mg/kg/day. At initiation of CyA therapy skin involvement was between 40 and 90% of total body surface. Initiation of CyA therapy resulted in marked improvement of skin lesions within 2–7 weeks accompanied by impressive relief from arthralgias and improvement of joint function. The requirement for nonsteroidal anti-inflammatory drugs was markedly reduced in all cases. All patients in whom CyA therapy was continued remained clinically stable for several months (follow-up period 2–7 months). Although mild to moderate relapses occurred, rebound phenomena were not observed after discontinuation of treatment. Side effects which comprised serum creatinine increases in 3 out of 6 cases were reversed by adjustment of CyA do

ISSN:1018-8665    

DOI:10.1159/000247305

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A 46-year-old woman with the Dowling-Meara variant of epidermolysis bullosa simplex (DM-EBS) presented with worsening recurrent, pruritic, circinate crops of clear and haemorrhagic herpetiform blisters affecting her trunk and limbs. Electron microscopy showed tonofilament aggregation and an intra-epidermal level of blister formation confirming a diagnosis of DM-EBS rather than an acquired immunobullous disorder. Antihistamines failed to control the intense pruritus, but dapsone (up to 150 mg daily) was beneficial. Mutations of basal cell keratin genes (K14 and K5) are thought to be of aetiopathological significance in this form of epidermolysis bullosa, but the underlying cellular mechanisms responsible for the clinical deterioration and severe itching in this adult patient are not yet clear.

ISSN:1018-8665    

DOI:10.1159/000247306

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We describe a case of primary infection by human parvovirus B19 in a 20-year-old woman; it manifested as erythemato-maculo-papular lesions, pharyngotonsillitis, lymphadenopathy, fever, arthralgia and myalgia, asthenia and anorexia. Laboratory tests revealed anaemia, leucopenia, thrombocytopaenia and a rise in some inflammatory indices. Elisa test was positive for anti-human parvovirus B19 IgM. Clinical symptoms spontaneously regressed in 2 weeks. Thirty days after hospital admission all the laboratory tests returned to normal values; furthermore, specific IgM and IgG were detectable.

ISSN:1018-8665    

DOI:10.1159/000247307

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Sterile epidermal neutrophilic pustulation can be observed in a variety of diseases. Though drug hypersensitivity is an uncommon cause, it is yet a known entity to be considered in the differential diagnosis of generalized pustulosis. In a 40-year-old woman, who developed a generalized pustular eruption after starting on doxycycline therapy of bronchitis, the rash was concluded to be drug induced after exclusion of other pustular dermatoses. Sensitization to doxycycline was demonstrated by in vitro lymphocyte testing and correlated with clinical drug hypersensitivity after recurrence of the pustular eruption on nonintentional rechallenge with doxycycline

ISSN:1018-8665    

DOI:10.1159/000247308

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000247309

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000247310

出版商:S. Karger AG    

年代:1993

数据来源: Karger