摘要:

Mammary and extramammary Paget’s disease is believed to remain non-pigmented, in contrast to superficial pagetoid melanoma; the same holds true for epidermotropic metastases of breast carcinoma. We recently had the opportunity to observe intensively pigmented epidermotropic metastasis of breast carcinoma, with dispersion of melanocytes in the dermal infiltrate. Similar observations, although exceedingly rare, have been reported: melanocytes ‘may’ pullulate within the dermo-epidermal foci of malignant epithelial cells. The final diagnosis relies on very careful analysis and, as far as possible, on immunohistological techn

ISSN:1018-8665    

DOI:10.1159/000246990

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

An unusually severe form of pityriasis lichenoides et varioliformis acuta (PLEVA) with a fatal outcome in an 82-year-old woman is reported. After a period of a mild eruption, extensive polymorphous, papular and ulcerohemorrhagic skin lesions developed, associated with intermittent high temperature and constitutional symptoms. Skin biopsies showed the typical histopathological changes of PLEVA. Early recognition of this severe variant of PLEVA is important, since the fulminating course can lead to death.

ISSN:1018-8665    

DOI:10.1159/000246991

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Because of their anti-inflammatory activity, corticosteroids generally mask the clinical signs of a contact dermatitis to a corticosteroid preparation. The lesions usually present as chronic dermatitis, and the patients mostly report not exacerbations but failures to respond to corticosteroid therapy, Moreover, masking also occurs with patch-test reactions obtained with corticosteroid preparations and the corticosteroid molecules themselves. These are important reasons why contact allergy to such preparations has frequently been missed in the past.

ISSN:1018-8665    

DOI:10.1159/000246992

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

A new directive from the European Union (EU) will restrict the use of nickel from 1996 on. The consequences of this directive in the EU are considered.

ISSN:1018-8665    

DOI:10.1159/000246993

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Background: The major problem of eosinophilic pustular folliculitis (EPF) is its generally unknown aetiology. Objective and methods: The purpose of this case report is to advise a thorough medical investigation of all patients with EPF. Results: The case of EPF presented seems to be associated with a chronic B-cell lymphatic leukaemia. Conclusion: Before regarding EPF as an idiopathic disease of unknown aetiology a thorough immunologic and haematologic investigation has to be advocated.

ISSN:1018-8665    

DOI:10.1159/000246994

出版商:S. Karger AG    

年代:1994

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000246995

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The concept of pseudo-factitial dermatitis can be defined as follows: any skin condition which, by its clinical or histopathological profile, can lead the clinician to an erroneous diagnosis of factitial dermatitis. Therefore, pseudo-factitial dermatitis does not exist as such; intellectually, it is of special interest for the practising dermatologist, in terms of differential diagnosis, either clinical or histopathological.

ISSN:1018-8665    

DOI:10.1159/000246996

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Background: Myofibroblasts (MF) from human granulation tissue derive from perilesional cells and display similarities with fibroblasts (DF) and smooth muscle cells (SMC). Objective: Determine additional markers to assess the phenotype of MF. Methods: MF, DF and SMC derived from human tissues were amplified in culture. Their phenotype and response to various regulatory processes were compared in vitro. Results: MF resemble SMC by their mechanical properties and cytoskeletal proteins. They resemble DF by their biosynthetic phenotype and their response to the regulation operated by the extracellular matrix and mechanical forces. Conclusion: In vitro MF display a phenotype that differentiates them from DF and SMC.

ISSN:1018-8665    

DOI:10.1159/000246997

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Junctional epidermolysis bullosa letalis type Herlitz Pearson is a genetically determined, life-threatening disease. Effective therapy has been lacking to date. Therefore any therapy that improves wound healing would be beneficial for these patients. Cultured epidermal grafts are known to enhance wound epithelialization and have been used with success in some epidermolysis bullosa disorders. Encouraged by these reports, we grafted cultured allogeneic keratinocytes to an infant with a junctional epidermolysis bullosa letalis type.

ISSN:1018-8665    

DOI:10.1159/000246998

出版商:S. Karger AG    

年代:1994

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000246999

出版商:S. Karger AG    

年代:1994

数据来源: Karger