摘要:

Systemic and sometimes topical therapy with fumaric acid (FA) and its derivatives is used in the treatment of psoriasis. Scattered data show that the topical application of these derivatives elicits side effects. Application of FA and some derivatives on the skin was accompanied by perilesional skin irritation, macular papular rashes and urticarial reactions. In order to determine the irritating and sensitizing properties of FA derivatives we used a cytotoxicity, flank irritation, ear swelling and guinea pig maximization test. The results of the cytotoxicity test demonstrated that dimethylfumarate (DMF) was the most toxic derivative. DMF induced also contact-urticarial reactions in contrast to mono-ethylfumarate (MEF). Challenge experiments with FA, MEF and DMF in MEF- and DMF-sensitized guinea pigs demonstrated that both MEF and DMF are moderate contact sensitizers. In DMF-sensitized animals cross-reactions with MEF were found. As DMF and MEF have cytotoxic, contact-urticarial and/or sensitizing properties, topical application should be avoided.

ISSN:1018-8665    

DOI:10.1159/000247116

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

In order to assess the antihistaminic power of cetirizine and ebastine, we designed a randomized, double-blind, crossover study, measuring their capacity to modify skin blood flow induced by a histamine prick test. The vasomotor response was compared using a laser Doppler flowmeter. Two hours after intake of the antihistaminic drug, there were significant differences between both drugs: at 4 h, the antihistaminic effect of cetirizine persists, whereas ebastine only showed moderate activity. The reduction of the cutaneous blood flow values (CBFV) showed good activity in both groups, but cetirizine was more potent and showed faster activity than ebastine.

ISSN:1018-8665    

DOI:10.1159/000247117

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

30 patients were treated with daily application of calcitriol (1α,25-dihydroxy-vitamin D3) ointment 15 μg/g in white petrolatum. The patients were divided into three groups according to the size of their total area of psoriasis. They were treated for 6 weeks, and investigated first with weekly and then with two-weekly estimations of calcium metabolism (serum calcium, 24-hour urinary calcium, parathyroid hormone, 25-hydroxyvitamin D3 and calcitriol). Ninety percent of the patients cleared or improved and there were no significant side effects or local intolerance. Cosmetic acceptance was good. No clinically significant changes in calcium metabolism were observed in spite of calcitriol application ranging between 73.98 and 306.10 μg daily (normal daily synthesis being 1–2

ISSN:1018-8665    

DOI:10.1159/000247118

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

158 patients with different forms of psoriasis were examined for the content of kallikrein and kallikreinogen in blood plasma and treated by different preparations including andecalin and dilminal-D. Changes in the kallikrein-kinin system may play a role in the development of psoriasis. The aim of this study was to investigate the relationship of changes in the kallikrein-kinin system induced by andecalin and dilminal-D and the clinical course of psoriasis. Determination of kallikrein and kallikreinogen content in blood plasma was made according to the methods of Paskhina and Krynskaya. Almost all psoriatic patients showed high kallikrein and kallikreinogen levels in blood plasma. We conclude that changes in the kallikrein-kinin system are involved in the pathogenesis of psoriasis. Andecalin and dilminal-D preparations resulted in a marked amelioration of psoriasis.

ISSN:1018-8665    

DOI:10.1159/000247119

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

We report a Japanese girl with atypical lipodystrophia centrifugalis abdominalis infantilis. The initial lesion developed on the neck as an area of erythema which showed centrifugal spread to the nape, submandibular area and upper breast and central fading to leave a residual depression and purplish brown pigmentation symmetrically. A central depression on the neck, nape, submandibular area and upper breast was surrounded by a distinctive erythematous, slightly elevated and indurated border. Histological examination of the erythematous border revealed inflammatory changes in the subcutaneous fat. Although this patient was affected in an unusual site, we concluded that she had lipodystrophia centrifugalis abdominalis infantilis, because of the overall features of the lesions.

ISSN:1018-8665    

DOI:10.1159/000247120

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Syringoacanthoma is a rare tumor derived from the eccrine acrosyringium; very few cases have been reported. The nosology of this tumor remains controversial. We present a new case of syringoacanthoma occurring in a 43-year-old woman; the lesion lasted for more than 30 years and caused partial destruction of the earlobe. Histopathologic examination showed a hyperkeratotic intraepidermal tumor, with many large cavities lined by an eosinophilic cuticle and filled with a PAS-positive substance. This case is probably a mutilating variant of syringoacanthoma, despite benign histopathologic features.

ISSN:1018-8665    

DOI:10.1159/000247121

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

A 19-year-old Japanese man with confluent and reticulated papillomatosis (CRP) is presented. He was an obese and dark-complexioned man, who had impaired glucose tolerance and hyperinsulinemia. The clinical and histological findings were consistent with the diagnosis of CRP. He also had acanthosis nigricans (AN) on his axillae and nape. Neither spores nor hyphae were detected from scales; antifungal treatment had no benefit. Although the reduction of his weight was unsuccessful, oral etretinate therapy resulted in considerable improvement of both CRP and AN. We reviewed previous case reports in terms of the relation between CRP and AN. Although the two conditions are usually differentiated because of their distinctive clinical features, a close relationship was noted between CRP and AN.

ISSN:1018-8665    

DOI:10.1159/000247122

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Sézary syndrome is a rare, usually monoclonal proliferation of T lymphoid cells. We report a case of this form of cutaneous T cell lymphoma with highly probable biclonality of neoplastic proliferation. Biclonality in malignant lymphoma is a rare feature, until now generally reported in B cell lymphoma. Its identification by accurate immunological studies could be of importance since one of the two populations can exhibit a less differentiated phenotype requiring a more aggressive therapeutic regimen than usual. The occurrence of anasarca in our patient was probably due to capillary leak syndrome, already discussed in another case of peripheral T cell lymphoma

ISSN:1018-8665    

DOI:10.1159/000247123

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

We report a Japanese case of Darier’s disease with brown and white papules or maculae distributed on the neck, trunk and dorsa of hands. Both brown papules and leukoderma showed typical histological features of Darier’s disease. Moreover, there were much fewer melanocytes and melanosomes in the epidermis of both lesions. The corneal layer of the brown papules was far thicker than that of the leukoderma. Therefore, the thick corneal layer of the brown papules may prolong the retention of a few melanosomes or a little melanin to induce hyperpigmentation, while the thin corneal layer of leukoderma may not do so, thereby producing hypopigmentation. The difference in clinical and histological courses after involvement of melanocytes was proposed to be the cause of the discrepancy between the previous reports. We conclude that leukoderma was the primary lesion, the postinflammatory depigmented spots, or the atypical or subclinical eruption of Darier’s di

ISSN:1018-8665    

DOI:10.1159/000247124

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

A case of autoerythrocyte sensitization syndrome in a 59-year-old female is reported. She had several episodes of circular ecchymoses on her left thigh. Intradermal injection of autoerythrocytes reproduced a similar ecchymosis. Thrombocytosis was detected and treated with busulfan which induced a delayed improvement of the ecchymosis outbreaks over 2 years of follow-up.

ISSN:1018-8665    

DOI:10.1159/000247125

出版商:S. Karger AG    

年代:1994

数据来源: Karger