摘要:

Results of in vitro studies on the penetration of a corticosteroid hydrocortisone 17-butyrate (HCB) in relation to the vehicle are reported. When HCB is dissolved completely in the vehicle, penetration is enhanced, and only under this condition an increase in HCB concentration (in the range 0.05–0.2%) leads to an increase in the penetration. Evaluation of the efficiency of various vehicles (an oil/water cream, Plastibase® or gels) in which HCB was dissolved in propylene glycol or ethanol, showed that Plastibase with propylene glycol was the most effective for both 0.1 and 0.2% HCB. The results of experiments in which HCB was applied in ethanolic solutions suggests that at least initially HCB and ethanol together penetrate through the epiderm

ISSN:1018-8665    

DOI:10.1159/000257865

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The eccrine nevus is an exceptional entity, formed by well-differentiated adnexa which can be classified as hamartoma or organoid nevus. It is characterized by a high degree of structural maturation. The authors report a case of eccrine nevus observed in a 32-year-old woman and compare clinical and histological features of the lesion with literature data.

ISSN:1018-8665    

DOI:10.1159/000251159

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

This paper reviews our modification of the vasoconstrictor (blanching) assay for topical corticosteroids using human volunteers, which we have improved and extended so that it may be used as a useful screening test for clinical efficacy besides being employed to determine the bioavailability of steroids from topical bases. Work is reported on the blanching activities of (1) 14 novel steroids in ethanol, (2) hydrocortisone 17-butyrate in eight topical vehicles, (3) betamethasone 17-benzoate in foam, ointment, cream and gel bases, and (4) 61 commercial formulations used in Great Britain. Pharmacokinetic/pharmacodynamic relationships are discussed as aids to optimizing topical steroid treatment.

ISSN:1018-8665    

DOI:10.1159/000257866

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Norwegian scabies in two female homozygous twins, 12 years of age, was observed. Both children were in good psychosomatical condition. Clinical signs of Norwegian scabies with appearance of verrucous and keratotic papules on the dorsal aspect of hands, elbows and knees appeared after a year of persisting typical scabies in their family. Serum vitamin A concentration was lowered. The pathogenesis of the disease is discussed. The long-standing typical scabies is thought to be a promoting factor for manifestation of the latent and hereditary predisposition to keratotic reaction of the skin.

ISSN:1018-8665    

DOI:10.1159/000251161

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The magnesium content of hair from alopecia areata atopica patients, from nonatopic dermatological patients and from normal controls has been studied using atomic absorption spectroscopy. The two groups of patients had lower means and ranges than did the normal subjects, but the overlap was considerable. It is suggested that the lower levels found in the patients may be due to the nonspecific ‘metabolic cost’ of the skin disea

ISSN:1018-8665    

DOI:10.1159/000251162

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251163

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251164

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Glucocorticoids exert valuable therapeutic activities in skin infections, although their use is limited by the occurrence of undesiderable effects: glucocorticoids depress the local defence mechanisms and, in low concentrations, stimulate microbial metabolism. For these reasons, combined preparations containing an antimicrobial substance besides the glucocorticoid are recommended. However, interactions between the steroids and the antimicrobials must be ruled out beforehand, i.e. the unimpaired activity of both steroid and antimicrobial must be assured. Examples of such investigations are reported for the most widely used compounds for topical therapy. The simultaneous use of a glucocorticoid and an antimicrobial is not recommended in only a few instances.

ISSN:1018-8665    

DOI:10.1159/000257867

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The use of measurement of skin thickness in guinea pigs has been compared with other techniques for assessment of topical applications. This method has provided us with an accurate evaluation of the corticosteroid dose-response curve and the effect of bases. The method has shown that non-steroid prostaglandin synthesis inhibitors can also be demonstrated to possess topical anti-inflammatory activity. As expected, indomethacin acts synergistically when formulated with hydrocortisone. Contrary to our expectation, both salicylic acid and acetylsalicylic acid show antagonism with hydrocortisone. This finding may be of clinical significance. We have also found that a combination of salicylic acid and indomethacin produces striking inflammatory changes in guinea pig skin which points to interaction of these two drugs in the guinea pig. The relevance of this phenomenon to both the mode of action of the two drugs and their use in clinical practice remains to be elucidated, but preliminary tests suggest that similar changes take place in human skin.

ISSN:1018-8665    

DOI:10.1159/000257868

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Following epimucous application of corticosteroids on the lips, narrowing and shortening of the terminal network of vessels occurs within 5–7 min. The decrease in infrared radiation needs a few more minutes. Contrary to the application of epinephrine-like substances, the change of the vessels occurs first in the superficial layers and only later on in the deeper layers. In addition to the effect on the muscles of the vessels, a narrowing of the capillaries can also be influenced by the effect of corticosteroids on the endothelial cells. Changes of the ground substance of the capillary vessel bed are also a possibilit

ISSN:1018-8665    

DOI:10.1159/000257869

出版商:S. Karger AG    

年代:1976

数据来源: Karger