摘要:

Three patients with atypical courses and manifestations of pityriasis lichenoides chronica (PLC) are presented. The first patient is a 21-year-old white woman who showed a good response of her PLC lesions as well as her reactive oligoarthritis to repeated PUVA treatments combined with oral prednisone during 1 year. The effect of the treatment then decreased. The patient developed a low-grade malignant lymphoma of the lung. When the lymphoma of the lung improved after chemotherapy, the PLC eruptions improved, too. The second patient is a 41-year-old man, whose Hodgkin’s disease stage IVa was successfully treated by chemotherapy and radiotherapy in 1984. In 1987 he showed PLC lesions which responded well to PUVA therapy, later also in combination with etretinate. Until 1988 repeated skin biopsies revealed a non-specific eczematous pattern. In 1989 the recalcitrant PLC eruptions finally revealed a pleomorphic non-Hodgkin lymphoma of the skin with medium-sized cells. The third patient had a PLC for about 9 years when Hodgkin’s disease stage la was diagnosed. At the beginning the skin biopsy showed an eczematous pattern, but 2 years later, in 1990, skin infiltrations of a large-cell, anaplastic non-Hodgkin lymphoma were seen. These cases show that PLC in rare cases may either represent a paraneoplastic skin disease or may itself develop into cutaneous lympho

ISSN:1018-8665    

DOI:10.1159/000247503

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Two cases of serpentine supravenous hyperpigmentation developing in the area of fotemustine infusions are reported. Histological features showed an increased melanin synthesis and the presence of melanophages without focal degeneration of basal cells or dermal inflammatory infiltrate. Perls’ strain was negative. Hypotheses concerning the mechanisms of increased melanin synthesis over the veins are discusse

ISSN:1018-8665    

DOI:10.1159/000247504

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A case is described of a patient with generalized myxoedema due to Hashimoto thyroiditis involving lesions of reticular erythematous mucinosis and acral papulokeratotic lesions with ‘church spire’ histological pattern. Substitutive treatment with thyroid hormone led to a rapid regression of the cutaneous lesions. The infrequent association of reticular erythematous mucinosis lesions and other forms of cutaneous mucinoses with hypothyroidism is discussed, with special emphasis on the fact that the underlying thyroid disease in all cases was Hashimoto thyroiditis. The association of distal keratotic papules with hypothyroidism has not been previously reported in the literat

ISSN:1018-8665    

DOI:10.1159/000247505

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Mai de Meleda (keratoderma palmoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma characterized by hyperkeratosis of the palms and soles which appears soon after birth and progressively (progrediens) involves other areas (transgrediens) of the body skin. We report the case of a patient with mal de Meleda with three unusual facultative features, i.e. prominent knuckle pads, peculiar finger-nail anomalies and pseudo-ainhum on both fifth fingers. Four other members of the family are also affected by mal de Meleda.

ISSN:1018-8665    

DOI:10.1159/000247506

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000247507

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000247508

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000247590

出版商:S. Karger AG    

年代:1992

数据来源: Karger