摘要:

Objective: Corneosurfametry is introduced as a noninvasive quantitative test rating the interaction between surfactants and human stratum corneum. It may be used as a predictive irritancy test. Background: Surfactants present in personal-care products elicit multiple effects on the stratum corneum. With upcoming regulations avoiding animal experiments and ethical considerations for human testing, there is a need for new in vitro methods evaluating irritancy. Design: Corneosurfametry entails collection of cyanoacrylate skin surface strippings and short contact time with surfactants followed by staining samples with toluidine blue and basic fuchsin dyes. Measurements are made by reading the color of samples using reflectance colorimetry. Results: The intensity of color increases with irritancy potential of the surfactant. Results are reproducible, and great differences are noted among a series of diluted shampoos, shower gels and facial cleansing gels. Conclusion: Corneosurfametry is proposed as a rapid in vitro method allowing a predictive grading of surfactants related to irritancy.

ISSN:1018-8665    

DOI:10.1159/000246820

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Background: Though rarely reported, mucin deposition may be observed in scleroderma. Objective: To verify the frequency of significant amounts of mucin in the biopsy specimens. Methods: Biopsies from 20 patients with scleroderma were reviewed and stained to verify the presence of mucin. Results: Mucin deposits were found in all of the 20 specimens. Conclusion: Mucin deposition is probably a constant feature in both morphea and systemic scleroderma. Its relevance in differential diagnosis between scleredema and scleroderma is debatable.

ISSN:1018-8665    

DOI:10.1159/000246821

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

A 46-year-old patient with ‘locked-in syndrome’ due to brainstem infarction developed symmetrically distributed, grouped erythematous cornified hemispherical papules on the fingertips and toes in 2 years. Histologically they showed psoriasiform changes. There was no evidence of internal malignancy nor a history of special drug intake. To our knowledge, such an eruption has not been previously repor

ISSN:1018-8665    

DOI:10.1159/000246822

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

We report a case of primary cutaneous melanoma with the incidental finding of a lung metastasis 27 years following the original diagnosis. The case is exceptional in that it is a late metastasis of a melanoma that arose in association with a halo giant congenital nevus. The original tumor was a large dermal/subcutaneous nodule composed of very well-differentiated cells reminiscent of type B nevomelanocytes. The metastasis displayed similar histology. This case emphasizes the unpredictable behavior of malignant melanoma. In cases with ‘unusual’ histology such as this one, the usual prognostic parameters are less helpful in predicting survival. Melanoma should be included in the differential diagnosis of an undiagnosed lesion suspicious for metastasis even if the primary was removed in the remote p

ISSN:1018-8665    

DOI:10.1159/000246823

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

We report on a 12-year-old girl infected with human immunodeficiency virus (HIV) who developed oral hairy leukoplakia (OHL). This is the fifth child with OHL whose case has been described so far. The clinical diagnosis was confirmed by ultrastructural documentation of a herpes-type virus in the lesional scraping specimen. Exfoliative material was obtained by a painless and noninvasive procedure. We conclude that ultrastructural examination of lingual exfoliative cytological specimens from clinically suspected OHL is a noninvasive and painless method for confirming the clinical diagnosis of OHL.

ISSN:1018-8665    

DOI:10.1159/000246824

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Inflammatory linear verrucous epidermal nevus (ILVEN) is a rather uncommon dermatosis that typically has an early age of onset, is unilateral, localized, pruritic and relatively refractory to treatment. Atypical presentations of ILVEN have also been described and include late onset in life, widespread involvement and response to treatment. We report the adult onset of an extremely pruritic systemized eruption in both mother and her daughter that clinically and histologically was most compatible with ILVEN. The eruptions were also partially responsive to therapy.

ISSN:1018-8665    

DOI:10.1159/000246825

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is a rare genodermatosis of which only 4 pedigrees have so far been reported. We present herein a new family with EBS-MP comprising a peculiar punctate digital keratoderma. The propositus was an 18-year-old patient who had suffered since birth from posttraumatic bullae, followed by mottled pigmentation, plantar keratosis, nail dystrophy and peculiar punctate keratoses of the fingers. Histology, immunofluorescence and electron microscopy of a bullous lesion showed an intraepidermal cleavage and an increased number of melanosomes within basal keratinocytes, dermal macrophages and Schwann cells. The precise genetic defect responsible for EBS-MP is not known but could be due to two distinct, closely linked mutations. The nosologic relationship between EBS-MP and other forms of EBS as well as cases of hereditary bullous poikilodermic acrokeratosis is discussed.

ISSN:1018-8665    

DOI:10.1159/000246826

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Cutaneous reactions to thalidomide therapy are reported infrequently. We report two new cases. Both patients suffered from chronic renal insufficiency and were on thalidomide therapy because of prurigo nodularis. The cutaneous reaction consisted of a severe erythematous rash progressing to erythroderma, associated with peripheral eosinophilia. In both cases rapid resolution occurred after withdrawal of thalidomide. We emphasize the possibility of a severe cutaneous hypersensitivity reaction due to thalidomide and speculate about the role played by the renal insufficiency present in both cases.

ISSN:1018-8665    

DOI:10.1159/000246827

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

A 45-year-old woman presented with a deep ulcerative lesion of the left breast. Two months later, a new cutaneous necrotic lesion located in the right pretibial area was observed. The only serum abnormality was the presence of circulating lupus anticoagulant. Clinical features suggested the diagnosis of pyoderma gangraenosum and histologic examination showed microthrombosis in the dermal capillary vessels adjacent to a dense, mixed inflammatory infiltrate with some degree of vascular damage. Although thrombosis may be the result of vasculitis, it is likely that in our patient the presence of a lupus anticoagulant activity played a role in the pathogenesis of the cutaneous ulcers.

ISSN:1018-8665    

DOI:10.1159/000246828

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

We describe a 30-year-old woman with syringomyelia, who developed recurrent painless whitlows of the left hand that led to amputation of the terminal phalanx of the 4th finger and considerable shortening of the terminal phalanges of the 1st, 2nd, 3rd and 5th fingers. A roentgenogram of the left hand showed a complete resorption of the terminal phalanges of the 3rd, 4th and 5th fingers and partial resorption of the terminal phalanx of the 2nd finger. Although the defective sensory function undoubtedly contributes to the development of bone resorption by facilitating mechanical repetitive injuries and infections, impaired vasomotor function possibly plays an equally important role.

ISSN:1018-8665    

DOI:10.1159/000246829

出版商:S. Karger AG    

年代:1994

数据来源: Karger