摘要:

In a series of hydrocortisone 17-esters, hydrocortisone 17-butyrate (HC-17B) has almost optimal lipophilicity resulting in a topical effect comparable to that of the fluorinated corticosteroids as measured in the McKenzie test on the human skin. In rats its systemic effects are weak, being in the order of those of hydrocortisone. In man systemic effects have been demonstrated, but no exact comparative data are available. Important factors controlling the intensity of systemic effects are: rate of liberation into plasma from the depot in the horny layer, rate of metabolic degradation, and rate of plasma clearance. In rats the main factor seems to be rapid clearance from plasma (t1/2 = 0.5 h) by selective concentration in the liver and, to a lesser extent, in the kidneys. Rapid hydrolysis by esterases in plasma and liver plays an additional role. In man hydrolysis by esterases appears to be rather slow; the rate of clearance from plasma is still unknown, whereas the absorption from the intact skin into the blood seems to be very slow (t1/2 = 25 h).

ISSN:1018-8665    

DOI:10.1159/000257889

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The systemic effects of topically applied 0.1% hydrocortisone 17-butyrate during treatment with and without occlusion were measured in terms of the functions of the pituitary-adrenal axis. Corticosteroid levels in the blood were determined by the modified method of Murphy, a competitive protein-binding radioassay. Circulating eosinophils were counted and the urinary 17-OHCS and 17-KS excretion were also determined. Percutaneous absorption following the topical application of 14C hydrocortisone 17-butyrate1 (HC 17-B, Locoid®) was measured by means of autoradiography. The application of the corticosteroid to the normal skin without occlusion did not induce systemic effects, whilst the application of the drug under occlusive dressing showed that systemic effects may possibly be induced. The number of circulating eosinophils, corticosteroid levels in the blood and urinary 17-OHCS excretion all decreased. However, these values returned to normal about 2 days after the withdrawal of the application, so we consider the systemic effects induced by the topical corticosteroid to be of a temporary nature. The percutaneous absorption of the corticosteroid was proved by an autoradiographic technique using 14C-labelled HC 17-B. At various intervals after the application, radioactive substances were observed as silver grains in the horny layer of the epidermis and skin appendages, and the density of the silver grains gradually increased with the course of time. It may be surmised that locally applied HC 17-B will be retained in the horny layer of the epidermis at a very early stage after the application and then absorbed in the blood via the epidermis and skin appendages. The reservoir of the corticosteroid in the skin was demonstrated 24 h after the withdrawal of the application

ISSN:1018-8665    

DOI:10.1159/000257890

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A randomized, double-blind, left-right comparative study was carried out to compare the value of hydrocortisone 17-butyrate with that of betamethasone 17-valerate in the treatment of eczematous skin disorders. In a series of 23 patients with such disorders, no differences between the two preparations was demonstrated with regard to effectiveness.

ISSN:1018-8665    

DOI:10.1159/000257891

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Absorption of antibiotics from combined preparations containing oxytetracycline, chlortetracycline, doxycycline or gentamicin and hydrocortisone 17-butyrate into the skin of rats was examined. The penetration of antibiotics from the ointment into the skin was inhibited by 0.2% hydrocortisone 17-butyrate to a significant degree. It is suggested that this effect of hydrocortisone 17-butyrate is the consequence of its vasoconstrictor action.

ISSN:1018-8665    

DOI:10.1159/000257892

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In a double-blind comparative study, by 29 dermatological departments, the activity of hydrocortisone 17-butyrate (HC 17-B, Locoid®), triamcinolone acetonide (TA) 0.1% and hydrocortisone 21-acetate (HA) 1%, were compared in patients suffering from acute eczematous dermatitis, atopic dermatitis and psoriasis. After a 7-day period of observation, the results were evaluated by means of a χ2 test, and an Armitage test. The following results were obtained: in acute eczematous dermatitis HC 17-B was found to be superior to the placebo and equal to TA; in atopic dermatitis HC 17-B was found to be superior to the placebo and HA, equal to TA; in psoriasis vulgaris HC 17-B was found to be superior to the placebo, HA and T

ISSN:1018-8665    

DOI:10.1159/000257893

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Description of adverse’ effects of strong corticosteroids in rosacea. Perioral dermatitis also seems to be caused by treatment with strong corticosteroids. The rebound effect after weaning the patient from strong corticosteroids might be obviated by hydrocortisone 17-butyrate or hydrocortisone 21-acetate. Continued oral tetracycline treatment is recommende

ISSN:1018-8665    

DOI:10.1159/000257894

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The clinical efficacy and the rebound phenomenon were studied in a left-right double-blind trial comparing triamcinolone acetonide (TA) and hydrocortisone 17-butyrate (HC 17-B, Locoid®). The trial comprised 19 patients with rosacea-like dermatitis of whom 7 did not receive treatment and 12 were pretreated with betamethasone valerate (BMV). Tetracycline was given all the time as additional treatment. Clinically there was no significant difference between TA and HC 17-B. No rebound phenomenon was observed. If corticosteroids are to be used at all in rosacea or rosacea-like dermatitis, preference is given to HC 17-B

ISSN:1018-8665    

DOI:10.1159/000257895

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Review of the history of topical steroid treatment, explaining the high acceptance and discussing the complications. Special attention is drawn to the fact that – though extremely rare – sensitization to various steroids is described. In 1 patient cross-sensitization occurred against six different corticosteroids, all fluorina

ISSN:1018-8665    

DOI:10.1159/000257896

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000257897

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000257898

出版商:S. Karger AG    

年代:1976

数据来源: Karger