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51. |
Book Reviews |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 107-107
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ISSN:1018-8665
DOI:10.1159/000246804
出版商:S. Karger AG
年代:1994
数据来源: Karger
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52. |
Pemphigus in Oxford, UK, and New Delhi, India: A Comparative Study of Disease Characteristics and HLA Antigens |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 108-110
C. Wilson,
F. Wojnarowska,
N.K. Mehra,
J.S. Pasricha,
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摘要:
A study of pemphigus in New Delhi, India, and Oxford, UK, was undertaken including 20 patients in Oxford and 50 in New Delhi. Data included clinical and histological subtypes and socio-economic data; patients were HLA typed. In New Delhi pemphigus vulgaris predominated, but in Oxford pemphigus vulgaris and pemphigus foliaceus have equal prevalence. Disease distribution with sex was the same, but age at onset was significantly lower in New Delhi (p = 0.0019). HLA typing in pemphigus vulgaris patients revealed a significant reduction in HLA-DR2 in New Delhi (p = 0.0008) and Oxford (p = 0.09). A small increase in HLA-DR1 and -DR4 was found in both groups and, in males only, a subtle increase in HLA-DR6 and reduction in HLA-DR3. No differences were found in the class I antigens. Thus there are striking differences in the types of pemphigus between the two populations, yet the genetic predisposition is the same.
ISSN:1018-8665
DOI:10.1159/000246946
出版商:S. Karger AG
年代:1994
数据来源: Karger
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53. |
Subcorneal Pustular Dermatosis Associated with IgA Myeloma and Intraepidermal IgA Deposits |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 111-114
M. Takata,
M. Inaoki,
M. Shodo,
T. Hirone,
H. Kaya,
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摘要:
We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-κ myeloma. Immunofluorescence tests showed intercellular IgA-κ deposits in the upper portion of the lesional epidermis and circulating IgA-κ anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-κ paraprotein produced by myeloma ce
ISSN:1018-8665
DOI:10.1159/000246947
出版商:S. Karger AG
年代:1994
数据来源: Karger
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54. |
Atypical Pemphigus with Concomitant IgG and IgA Anti-Intercellular Autoantibodies Associated with Monoclonal IgA Gammopathy |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 115-116
H. Ohno,
S. Miyagawa,
T. Hashimoto,
A. Nakagawa,
K. Watanabe,
T. Nishikawa,
T. Shirai,
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摘要:
A case is reported of a 60-year-old woman with acantholytic vesiculopustular dermatosis and IgA-λ monoclonal gammopathy. The histopathology of vesiculopustular lesions showed intraepidermal acantholytic and neutrophilic blisters. Direct immunofluorescence revealed intercellular (IC) IgG deposition with concurrent deposits of IgA and C3. Indirect immunofluorescence and immunoblotting studies revealed that the patient had circulating IgG and IgA anti-IC antibodies both of which recognized the 150-kD desmoglein that was pemphigus foliaceus antigen in a bovine desmosome preparation
ISSN:1018-8665
DOI:10.1159/000246948
出版商:S. Karger AG
年代:1994
数据来源: Karger
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55. |
Bullous Pemphigoid Complicated with Pemphigus vulgaris? |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 117-119
J. Ninomiya,
A. Nakabayashi,
Y. Sei,
I. Takiuchi,
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摘要:
A 67-year-old housewife had polymorphous eruptions with tense bullae on the extremities and upper trunk. Erosions were noted on the oral and esophageal mucosa. A skin biopsy showed subepidermal blistering with linear deposition of IgG and C3 at the basement membrane zone. In addition, intercellular deposition was observed at the lower part of the epidermis. On the basis of clinical and histological features, a diagnosis of bullous pemphigoid (BP) was made. After she was treated with prednisolone, the whole-skin lesions soon disappeared. An esophageal biopsy showed intercellular deposition of IgG and C3. Indirect immunofluorescence testing using esophageal mucosa of guinea pigs showed the same deposition at the titer of 1:20. Immunoblottings with this patient’s serum revealed no reactions with either BP or pemphigus antigens. Her serum reacted strongly with a 190-kD protein, the nature of which was unknown. A treatment with ciclosporin was added to this steroid therapy, and the mucosal lesions improved graduall
ISSN:1018-8665
DOI:10.1159/000246949
出版商:S. Karger AG
年代:1994
数据来源: Karger
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56. |
A New Bullous Pemphigoid Antigen |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 120-122
S. Fujiwara,
K. Kohno,
A. Iwamatsu,
H. Shinkai,
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摘要:
Previously we reported a case of subepidermal blistering disease, which resembled bullous pemphigoid clinically. An immunoblot analysis revealed that the patient’s serum reacted exclusively with a 450-kD epidermal polypeptide. The 450-kD antigen was also expressed in human keratinocytes and a human squamous carcinoma (HO 1-u-1 or A431) cell line. Using the patient’s serum, cDNA clones in a bacteriophage λgt11 library derived from human foreskin keratinocytes were immune-screened. One positive clone was isolated from 2 million clones. Northern blot analysis showed that the inserted part of this clone hybridized with a more than 12-kb mRNA species derived from HO 1-u-1 cells. The deduced amino acid sequence had no homology with any other human compo
ISSN:1018-8665
DOI:10.1159/000246950
出版商:S. Karger AG
年代:1994
数据来源: Karger
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57. |
‘Salt-Split’ Test on Normal, Non-Sun-Exposed Skin of Patients with Autoimmune Subepidermal Bullous Diseases |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 123-123
G. Pohla-Gubo,
E. Becker,
N. Romani,
P. Fritsch,
H. Hintner,
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ISSN:1018-8665
DOI:10.1159/000246951
出版商:S. Karger AG
年代:1994
数据来源: Karger
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58. |
Two Different Isoforms of Desmocollin Are Recognized by Autoantibodies in Various Types of Pemphigus |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 124-125
T. Hashimoto,
T. Ebihara,
T. Nishikawa,
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摘要:
We have previously reported that, in addition to well-known pemphigus antigens (desmoglein and pemphigus vulgaris antigen), desmocollin (Dsc), another desmosomal cadherin, is recognized by certain pemphigus sera. Furthermore, we noticed that two Dsc species with a slightly different relative molecular weight were recognized by various pemphigus sera. This difference may contribute to the different clinicopathological features between the subcorneal pustular dermatosis type and the intraepidermal neutrophilic IgA dermatosis type of intercellular IgA vesiculopustular dermatosis.
ISSN:1018-8665
DOI:10.1159/000246952
出版商:S. Karger AG
年代:1994
数据来源: Karger
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59. |
A Case of Bullous Pemphigoid with Antidesmoplakin Autoantibodies |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 126-128
K. Watanabe,
T. Hashimoto,
A. Ishiko,
H. Shimizu,
T. Nishikawa,
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摘要:
We present an 84-year-old Japanese male showing typical features of bullous pemphigoid (BP). However, immunofluorescence of normal human skin sections revealed concurrent anti-basement-membrane-zone and anti-keratinocyte-cell-surface autoantibodies in the serum. With immunoblotting, the patient’s serum reacted with desmoplakins I and II, as well as with both the 230-kD and the 180-kD BP antigens. The studies for this case may provide us with an insight to understand the occurrence of antidesmoplakin antibodies in paraneoplastic pemphigu
ISSN:1018-8665
DOI:10.1159/000246953
出版商:S. Karger AG
年代:1994
数据来源: Karger
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60. |
A Case of Pemphigus foliaceus after Interferon Alpha-2a Therapy |
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Dermatology,
Volume 189,
Issue 1,
1994,
Page 129-130
H. Niizeki,
N. Inamoto,
K. Nakamura,
K. Tsuchimoto,
T. Hashimoto,
T. Nishikawa,
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摘要:
We present here a 63-year-old man with chronic hepatitis C who developed bullous lesions and anti-intercellular antibodies when he received interferon (IFN) α-2a, 9 MU subcutaneously, 3 times a week for 3 months. The direct immunofluorescence was consistent with pemphigus features. The indirect immunofluorescence showed negative before IFN treatment, but it became positive after 3 months. The immunoblot study showed no specific bands. This is the third report of the bullous lesions with anti-intercellular antibodies following IFN therapy
ISSN:1018-8665
DOI:10.1159/000246954
出版商:S. Karger AG
年代:1994
数据来源: Karger
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