摘要:

Increased epidermal calmodulin (CaM) levels have been reported in psoriatic lesions. It has been suggested that CaM inhibition might be of relevance in the treatment of psoriasis vulgaris. Therefore we investigated the possible CaM inhibition by the antipsoriatic drug anthralin in vitro and in vivo. For in vitro studies, anthralin (0.44 mM) effects on the CaM-dependent Ca++-ATPase of CaM-depleted erythrocyte ghosts were assessed. At 100 μM Ca++ no enzyme inhibition was measured either in the presence or absence of CaM. At 2 μM Ca++ anthralin inhibited the CaM stimulation of membrane-bound ATPase for 50% in presence of CaM. For in vivo studies, skin biopsies were taken from anthralin-treated psoriatic lesions without scaling but still palpable infiltration during the first 3 weeks of therapy. Lesions with anthralin-induced irritation were excluded. The epidermal CaM level was determined by measuring the ability of soluble epidermal protein to activate the Ca++-ATPase in CaM-depleted erythrocyte ghosts. Epidermal CaM was 7.07 ± 4.57 (mean ± SD) μg CaM/mg soluble epidermal protein. This is a 6-fold increase compared to normal human epidermis and a 3-fold increase compared to nontreated lesional psoriatic epidermis (p < 0.01 and 0.02, respectively). The results argue against CaM inhibition of psoriatic epidermal keratinocytes as the primary event in the antipsoriatic action of anthr

ISSN:1018-8665    

DOI:10.1159/000248312

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Interleukin 1 (IL-1) has been implicated in the production of characteristic changes in psoriatic lesions such as epidermal hyperprohferation and accumulation of polymorphonuclear leukocytes within the epidermis. Because lobenzarit disodium, an immunomodulator, inhibits the production of IL-1 in peripheral and peritoneal macrophages, we studied the clinical effects of this compound on psoriatic lesions. A 12-week course of oral lobenzarit disodium treatment did not induce any remarkable changes in psoriasis lesions. This does not support the major pathogenic role of IL-1 in the development of psoriasis.

ISSN:1018-8665    

DOI:10.1159/000248313

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

In this study several schedules of discontinuous application (DA) were tested, using various weak and strong topical corticosteroids (CS). The purpose of this study was to measure the influence of corticosteroids on skin thickness by means of a mechanical method. In a first experiment, betamethasone 17,21-dipropionate (Bet) and fluprednidene 21-acetate (Flu) were applied to the skin of the volar side of the forearm at a rhythm of 1:1 (1 day CS 1-day interval) and 1:2 under occlusive dressing. The investigation period was 8 weeks. For comparison, Bet and Flu were applied continuously (CA) for 3 weeks. Flu thinned the skin to a lesser extent than Bet. With DA the skin was thinned to the same extent as with CA. In a second experiment, hydrocortisone 17-butyrate, betamethasone 17-valerate, desoxymethasone and hydrocortisone were tested. Here the treatment regimen was 5:9. The CS preparations were tested for 3 months on the volar side of the forearms under occlusive dressing. Skin thinning occurred during the 5 days of CS action and in the beginning receded again in the CS-free interval. However this regressive process became weaker each time. At the end of the experiment the skin thinning persisted. With the exception of hydrocortisone, all CS tested produced statistically significant skin thinning after DA. The results of the investigation presented here show that thinning of the skin must also be expected with discontinuous application of topical CS.

ISSN:1018-8665    

DOI:10.1159/000248314

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Acute pancreatitis may be a rare complication of systemic corticosteroids, although this is disputed. We describe a patient with bullous pemphigoid whose treatment was complicated by fatal acute pancreatitis.The question of a cause and effect relationship is discussed with reference to the literature. We emphasise the way that corticosteroids modified the presentation of acute pancreatitis in this case.

ISSN:1018-8665    

DOI:10.1159/000248315

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

A 55-year-old patient was treated with a combination of minoxidil and retinoic acid. After 1 month an explosive eruption of pyogenic granuloma appeared on the scalp. Despite redness and itchy reaction, caused only by the test containing both chemicals, histology did not give evidence of contact allergy.

ISSN:1018-8665    

DOI:10.1159/000248316

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

We have encountered 2 cases (mother and son) with an autosomal dominant form of cutis laxa, which is clinically characterized by inelastic, loose, and pendulous skin without systemic organ involvement. The histopathological findings disclosed that the elastic fibers were decreased in number and had abnormalities in shape. Furthermore, electron microscopic observations showed some variations in structural abnormalities of the elastic fibers between the 2 cases.These findings may suggest that the elastic fibers seen in congenital cutis laxa give various features for elastogenesis and elastolysis in the individual cases, perhaps due to aging.

ISSN:1018-8665    

DOI:10.1159/000248317

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

A 35-year-old man with a solitary subcutaneous cord running on the abdomen wall is reported. Histologic examination of the lesion permitted a diagnosis of plexiform neurofibroma. In this patient and in his family no other signs of von Recklinghausen’s disease were found. The plexiform neurofibroma considered as pathognomonic of neurofibromatosis may occur in a solitary for

ISSN:1018-8665    

DOI:10.1159/000248318

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

We report an additional case of melanoacanthoma, a rare benign mixed tumor of both keratinocytes and melanocytes occurring in a 66-year-old man on the penis shaft a localization not previously described. Clinical and histological features are briefly discussed.

ISSN:1018-8665    

DOI:10.1159/000248319

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248320

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248321

出版商:S. Karger AG    

年代:1989

数据来源: Karger