摘要:

By atomic absorption spectrometry, nickel was analysed in many foodstuffs. The results of these determinations are given in detail. Nickel present in vegetables comes primarily from the soil but secondarily from stainless-steel cooking utensils.

ISSN:1018-8665    

DOI:10.1159/000250641

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A case of localized urticaria in an otherwise healthy young woman, produced only by direct contact of the skin with heat, is described. The minimal temperature of urtication was 44°C (immersion of the forearm in hot water for 5 min). Redness and painful oedema immediately developed without reflex flare. Total serum IgG, IgA, IgM, IgE, complement factors C3 and C4, and α1-antitrypsin were in the normal range, whereas the C1-inhibitor level was slightly decreased. There was no evidence of circulating immune complexes in the serum. A skin test and a RAST with house dust were positive, but there were no signs of respiratory atopy. An attempt for passive transfer of heat urticaria into the abdominal skin of a rhesus monkey failed, but was successful for house dust. A treatment trial with ketotifen, a new, perorally acting anti-allergic drug, was poorly effective, but dexchlorpheniramine maleate, a classical antihistaminic, in a dose of 12 mg daily completely suppressed the swelling evoked by heat, but not the erythema, suggesting that other tissue or plasma factors than histamine may be involved in the mechanism of heat urticaria in this patien

ISSN:1018-8665    

DOI:10.1159/000250642

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Junctional blister formation is the common feature of four clinically different types of inherited epidermolyses with atrophies but lack of scarring which, as a group, have been termed epidermolysis bullosa atrophicans. The Herlitz type is the most common one among them. Based on a material of 24 cases aged 2 days to 42 years at the time of biopsy, ultrastructural data on the pathomorphogenesis are reported. Blisters form in the dermo-epidermal junction area between the basal lamina and the basal cell plasma membrane. A well-developed basal lamina-anchoring fibrils complex covers the blister floor. Hypoplasia of hemidesmosomes precedes blister formation and is a constant finding in intact junction areas without any other signs of disturbances. It is, therefore, regarded as a causal factor in the pathogenesis. Nail loss as a result of junctional separation within the nail bed, secondary changes in older blisters and formation of slowly healing granulation tissues are also reported. – Early diagnosis is made available by electron microscopy as shown in our early childhood cases. Genes coding for junctional epidermolyses seem to be far more frequent than those coding for the scarring or dystrophic type

ISSN:1018-8665    

DOI:10.1159/000250643

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Delayed type hypersensitivity against staphylococcal antigens could be induced in guinea pigs by injecting the animals with a staphylococcal homogenate in Freund’s adjuvant in all four foot pads and the nuchal skin. Maximal skin reactivity, tested intracutaneously, was observed 21 days after sensitization. Highest stimulation of lymph node cells and peripheral blood lymphocytes was also obtained 21 days after sensitization. When comparing cell walls, cell materials (nonsoluble material obtained after the separation of the cell wall fraction) and soluble fraction (obtained after sedimentation of all nonsoluble material, the strongest skin test reactions occurred after testing intracutaneously with the cell wall fractio

ISSN:1018-8665    

DOI:10.1159/000250644

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In 4 patients with mycosis fungoides in the praemycotic, infiltrative and tumour stage of the disease, a differentiation and functional characterization of the infiltrate cells, obtained from cell suspensions and cutaneous smears, was carried out by means of enzyme cytochemical and immunological methods. The lymphocyte-associated acid esterase is considered to be a marker for mature T-cell populations. Apart from monocytes and histiocytes, acid esterase-positive small lymphocytoid cells with T-cell properties are found in the praemycotic stage. In the tumour stage, large lymphocytoid cells become increasingly prevalent, they show no acid esterase activity, but an intracytoplasmatic-localized reaction in the acid phosphatase activity. On the basis of the cytochemical pattern, it is assumed that these cells represent proliferating lymphoblasts.

ISSN:1018-8665    

DOI:10.1159/000250645

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Symptomatology and pathogenesis of porphyria cutanea tarda (PCT) are shortly reviewed. The different possibilities in the treatment of PCT are discussed with special reference to the phlebotomy according to Ippen and to the chloroquine administration according to the regimen described by Kordac and Semradova in 1974. 75 PCT patients were treated with chloroquine (Resochin®, Nivaquine®). After 9.3 ± 3.4 months (means ± SE) all patients excreted normal amounts of porphyrins, and the clinical symptoms disappeared. 14 of these patients relapsed after a mean period of 21 months after the withdrawal of chloroqu

ISSN:1018-8665    

DOI:10.1159/000250646

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000250647

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The clinical symptomatology of epidermolysis bullosa atrophicans generalisata gravis (Herlitz’ disease), epidermolysis bullosa atrophicans generalisata mitis (typus Disentis) and epidermolysis bullosa atrophicans localisata is described. These types belong to the non-scarring epidermolyses and show ultrastructurally junctional blisterin

ISSN:1018-8665    

DOI:10.1159/000250648

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000250649

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000250650

出版商:S. Karger AG    

年代:1979

数据来源: Karger