摘要:

After an historical survey, the various modern serologic tests for syphilis are dealt with. The humoral immunological phenomena, which develop in a certain chronological order, antilipoidal (non-specific) and antitreponemal (specific) antibodies of the classes IgM and IgG are presented. Particularly the demonstration of specific antitreponemal antibodies of the IgM class has opened up new perspectives in the serologic diagnostics of syphilis. For the present, screening examinations and the confirmation of the diagnosis are the domain of the specific tests (TPHA, FTA), while for the assessment of the therapy effect and of reinfection the unspecific tests (VDRL) are still to be employed.

ISSN:1018-8665    

DOI:10.1159/000249947

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Since there has been an increase in the number of patients suffering from syphilis during the last 2 decades, neurosyphilis has to be seriously considered in many unclear neurological cases. Atypical, often monosymptomatic clinical pictures make the diagnosis difficult. The exact analysis of the spinal fluid including antibodies against Treponema pallidum is necessary for the diagnosis. In contrast to former treatment schedules, now ultra high doses of penicillin are recommended and seem to be absolutely necessary.

ISSN:1018-8665    

DOI:10.1159/000249948

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

From 1970 to 1980 we observed 12 cases of typical neurosyphilis in Geneva. These patients had never had penicillin treatment. The incidence is about 0.3 per 100,000 inhabitants. However, it is possible that some patients with atypical neurosyphilis could have been discovered among our late serological syphilis cases if lumbar punctures and complete neurological examinations could have been carried out.

ISSN:1018-8665    

DOI:10.1159/000249949

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

We examined sera of syphilitic patients by solid-phase hemadsorption which provides specific anti-treponemic IgM titers. The results are encouraging and show that this method will probably be useful to monitor the treatment of syphilitic patients.

ISSN:1018-8665    

DOI:10.1159/000249950

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249951

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249952

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249953

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249954

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249955

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

By elimination of immune defenses, high doses of cortisone may cause precancerosis to degenerate into cancer. If cancer is already in existence, elimination of the immune defenses leads to a massive activation of the carcinoma, to anaplastic modification of the cancer cells, and to the most alarming development, the forming of metastases. These findings from the experiments performed show very clearly that the fate of cancer patients largely depends upon the reaction of local and general defenses. Further considerations demonstrate the importance of defense reactions in the pathogenesis of carcinomas and other malignant growths. It is concluded that research can only grasp the pathogenesis of carcinomas and other malignomas if – in a differentiated way – it concerns itself with the gradual diminution of the defense factors during the time of latency in the development of the malignant disease. It is in this context that we may find the possibility of therapeutic influence upon the development of can

ISSN:1018-8665    

DOI:10.1159/000249956

出版商:S. Karger AG    

年代:1982

数据来源: Karger