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| 1. |
Normal Merkel Cells Express a Synaptophysin-Like Immunoreactivity |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 1-10
J.P. Ortonne,
J.P. Petchot-Bacque,
P. Verrando,
A. Pisani,
G. Pautrat,
F. Bernerd,
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摘要:
Synaptophysin (SY), a specific component of the membrane of presynaptic vesicles, has been reported as a novel marker for neurons, certain neuroendocrine cells and their neoplasms including neuroendocrine carcinomas of the skin. The origin of the Merkel cells (MC) being far from clear, this study was performed to establish if normal MC express SY. It is demonstrated by immunofluorescence and immunoelectron microscopy using a monoclonal antibody SY38 to this glycoprotein that normal MC in man, rabbit and pigs express an SY-like reactivity. Although immunoblotting identification of the immunoreactive material gave negative results, it is likely that normal MC contain SY. By immunoelectron microscopy, the staining was located at the surface of cytoplasmic vesicles. In view of the possible involvement of SY in the Ca2+-dependent neurotransmitter release, the observation of an SY-like immunoreactivity in MC supports the view that they are epithelial neuroendocrine cells and that they may possess a neurosecretory function.
ISSN:1018-8665
DOI:10.1159/000248491
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 2. |
Immunohistological Study of Captopril-Induced Late Cutaneous Eruptions |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 11-15
N. Bretin,
B. Dreno,
B. Bureau,
P. Litoux,
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摘要:
Immunohistological study of dermal infiltrate from two pempigus- and one captopril-induced lichenoid eruption showed the presence of a CD8 (T suppressor) infiltrate that resembled that found in skin eruptions induced by graft-versus-host disease. It is suggested that a T cell cytotoxic reaction occurs in the epidermis that might be triggered by captopril-induced modification of keratinocytic antigens
ISSN:1018-8665
DOI:10.1159/000248493
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 3. |
Eruptive Pyogenic Granulomas and Acne fulminans in Two Siblings Treated with Isotretinoin |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 16-18
D. Blanc,
M. Zultak,
D. Wendling,
F. Lonchampt,
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PDF (941KB)
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摘要:
We report the case of two siblings, one of whom presented isotretinoin-induced eruptive pyogenic granulomas in the course of severe acne, and the other developed isotretinoin-induced acne fulminans. A possible underlying common pathogenic process of these two side-effects of isotretinoin is discussed.
ISSN:1018-8665
DOI:10.1159/000248496
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 4. |
Nifedipine Treatment of Raynaud’s Phenomenon Secondary to Chemotherapy |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 19-20
Lone Bachman Andersen,
Kristian Thestrup-Pedersen,
Arne Sell,
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PDF (717KB)
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ISSN:1018-8665
DOI:10.1159/000248498
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 5. |
Sweet’s Syndrome in Pregnancy |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 20-21
Uma Saxena,
V. Ramesh,
R.S. Misra,
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PDF (783KB)
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ISSN:1018-8665
DOI:10.1159/000248500
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 6. |
On Psoriasis and Associated Diseases |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 21-22
M. Krasteva,
G. Mateev,
A. Lasarova,
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PDF (731KB)
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ISSN:1018-8665
DOI:10.1159/000248502
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 7. |
In Reply |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 22-23
Bengt Lindegård,
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PDF (637KB)
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ISSN:1018-8665
DOI:10.1159/000248504
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 8. |
A Trial of Oral 1α-Hydroxyvitamin D3for Ichthyosis |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 23-23
Masaki Okano,
Yukio Kitano,
Kunihiko Yoshikawa,
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PDF (295KB)
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ISSN:1018-8665
DOI:10.1159/000248505
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 9. |
Free Communications |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 24-31
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PDF (2781KB)
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ISSN:1018-8665
DOI:10.1159/000248506
出版商:S. Karger AG
年代:1988
数据来源: Karger
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| 10. |
Hypoplasie dermique en aires |
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Dermatology,
Volume 177,
Issue 1,
1988,
Page 32-33
E. Frenk,
J.F. Vust,
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PDF (661KB)
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摘要:
A typical case of focal dermal hypoplasia is described. Despite its widely distributed cutaneous involvement, the only extracutaneous anomaly observed was a syndactyly of the 2nd and 3rd digits of the right foot.
ISSN:1018-8665
DOI:10.1159/000248507
出版商:S. Karger AG
年代:1988
数据来源: Karger
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