摘要:

Significant suppression of the hypothalamic-pituitary-adrenal axis has been found in patients hospitalized with psoriasis vulgaris and receiving topical fluorinated steroid therapy. Depression of thyroid function and involvement of autoimmune processes is also suggested by the data.

ISSN:1018-8665    

DOI:10.1159/000251089

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Application of retinoic acid (vitamin A acid) to animal and human skin has been reported to produce cutaneous, proliferative lesions which microscopically and histochemically resemble those of psoriasis. In the present studies, the daily application of a 0.1 % solution of retinoic acid to the dorsal ear surface of guinea pigs produced a progressive psoriasiform scaling which was apparent grossly and which could be quantitated. Triamcinolone acetonide, hydrocortisone and methotrexate, all known to be useful clinically in the treatment of psoriasis, were examined for their ability to antagonize the development of retinoic-acid-induced scaling. Systemic activity was observed with all three agents; topical activity was obtained with triamcinolone acetonide but not with methotrexate or several of its analogs. On the basis of activity profiles obtained with standard anti-psoriatic compounds, it is suggested that retinoic acid lesions may have utility in identifying the anti-psoriatic potential of new compounds.

ISSN:1018-8665    

DOI:10.1159/000251090

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Of 5,033 patients examined between 1968 and 1975, 407 were diagnosed as having psoriasis (Ps) and 23 alopecia areata (Aa). Five of the 23 patients with Aa had also Ps. One Aa patient having pitting of the nail only was not included in the Ps group. One further patient with Aa himself not affected with Ps had a sibling with Ps. It is suggested that there is an association between Ps and Aa and that the pitting of the nails described in Aa may be in reality an expression of Ps.

ISSN:1018-8665    

DOI:10.1159/000251091

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

T and B peripheral blood lymphocytes were evaluated in 17 patients with clinical and histological evidence of mycosis fungoides and in ten patients with benign lymphoplasias of the skin. The T subpopulation (T-Ea) characterized by a rapid rosette formation with sheep erythrocytes was also measured in these patients. While both T-total population (T-Et) and T-Ea subpopulation were within the normal range in pseudolymphoma group, a statistically significant decrease was observed in T-Ea and T-Et populations in the mycosis fungoides group. Moreover, the decrease in T-Ea subpopulation was found in all cases under investigation, even when T-Et population was still at the normal levels. A close relation between T-Ea values and clinical status was observed. B and null cells were substantially unchanged in all patients.

ISSN:1018-8665    

DOI:10.1159/000251092

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A 6-year-old boy with nail changes compatible with those seen in Reiter’s disease, and his father with chronic arthritis, recurrent anterior uveitis and amyloidosis, and a transplanted kidney are described. Both of them had HLA combination A2, B27 and neither had any of the antigens associated with psoriasi

ISSN:1018-8665    

DOI:10.1159/000251093

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A case of acrogeria in a 12-year-old girl is reported. Acrogeria is a rare, non-hereditary, probably congenital disease of which the main characteristic is an atrophy of the skin giving it an aged appearance. The defect is localized to the dermis and subcutis, whereas the epidermis seems not to be affected. The disease might be associated with other congenital malformations.

ISSN:1018-8665    

DOI:10.1159/000251094

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Chronic myeloid leukaemia was observed 20 months after onset of pyoderma gangraenosum in a 35-year-old female. In this case an induction by cytostatic drugs could be excluded, confirming the association of pyoderma gangraenosum with leukaemias.

ISSN:1018-8665    

DOI:10.1159/000251095

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Procaine chloride, which was a common cause of allergic reactions in earlier years, has lost importance as a contact allergen because its use for local anaesthesia has ceased. Recently, we have seen hypersensitivity reactions in three patients after the use of Gerovital®, which is known to contain procaine chloride. A word of warning is warranted against indiscriminate use of Gerovital, particularly of its topical preparations

ISSN:1018-8665    

DOI:10.1159/000251096

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251097

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251098

出版商:S. Karger AG    

年代:1977

数据来源: Karger